Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017348165> ?p ?o ?g. }
- W2017348165 endingPage "196" @default.
- W2017348165 startingPage "185" @default.
- W2017348165 abstract "Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors cause an initial injury to the cartilage resulting in release of several cartilage specific auto-antigens, which trigger the activation of immune response. Immune cells including T cells, B cells and macrophages infiltrate the joint tissues, cytokines and chemokines are released from different kinds of cells present in the joint, complement system is activated, and cartilage degrading factors such as matrix metalloproteinases (MMPs) and prostaglandin E2 (PGE2) are released, resulting in further damage to the articular cartilage. There is considerable success in the treatment of rheumatoid arthritis using anti-cytokine therapies. In OA, however, these therapies did not show much effect, highlighting more complex nature of pathogenesis of OA. This needs the development of more novel approaches to treat OA, which may include therapies that act on multiple targets. Plant natural products have this kind of property and may be considered for future drug development efforts. Here we reviewed the studies implicating different components of the immune system in the pathogenesis of OA." @default.
- W2017348165 created "2016-06-24" @default.
- W2017348165 creator A5057245262 @default.
- W2017348165 creator A5075787118 @default.
- W2017348165 date "2013-03-01" @default.
- W2017348165 modified "2023-09-29" @default.
- W2017348165 title "Immunopathogenesis of osteoarthritis" @default.
- W2017348165 cites W1607875640 @default.
- W2017348165 cites W1929515229 @default.
- W2017348165 cites W1963657283 @default.
- W2017348165 cites W1964132223 @default.
- W2017348165 cites W1967024742 @default.
- W2017348165 cites W1967357201 @default.
- W2017348165 cites W1967469609 @default.
- W2017348165 cites W1969540068 @default.
- W2017348165 cites W1971066261 @default.
- W2017348165 cites W1971355172 @default.
- W2017348165 cites W1971710323 @default.
- W2017348165 cites W1972861978 @default.
- W2017348165 cites W1974996960 @default.
- W2017348165 cites W1975777695 @default.
- W2017348165 cites W1977564820 @default.
- W2017348165 cites W1979971922 @default.
- W2017348165 cites W1979972616 @default.
- W2017348165 cites W1980409139 @default.
- W2017348165 cites W1981199758 @default.
- W2017348165 cites W1981799488 @default.
- W2017348165 cites W1982564040 @default.
- W2017348165 cites W1983063657 @default.
- W2017348165 cites W1983345459 @default.
- W2017348165 cites W1984367241 @default.
- W2017348165 cites W1987383242 @default.
- W2017348165 cites W1993922139 @default.
- W2017348165 cites W1996058009 @default.
- W2017348165 cites W1996501296 @default.
- W2017348165 cites W1997957358 @default.
- W2017348165 cites W1998866269 @default.
- W2017348165 cites W2001405211 @default.
- W2017348165 cites W2002398009 @default.
- W2017348165 cites W2003442374 @default.
- W2017348165 cites W2004062708 @default.
- W2017348165 cites W2005091462 @default.
- W2017348165 cites W2008430756 @default.
- W2017348165 cites W2008596857 @default.
- W2017348165 cites W2010802338 @default.
- W2017348165 cites W2011471302 @default.
- W2017348165 cites W2011509273 @default.
- W2017348165 cites W2014458492 @default.
- W2017348165 cites W2014751598 @default.
- W2017348165 cites W2014952783 @default.
- W2017348165 cites W2016594353 @default.
- W2017348165 cites W2017604635 @default.
- W2017348165 cites W2017720269 @default.
- W2017348165 cites W2017750008 @default.
- W2017348165 cites W2017824359 @default.
- W2017348165 cites W2022640830 @default.
- W2017348165 cites W2023723670 @default.
- W2017348165 cites W2024452130 @default.
- W2017348165 cites W2028255006 @default.
- W2017348165 cites W2029355740 @default.
- W2017348165 cites W2029818075 @default.
- W2017348165 cites W2032010202 @default.
- W2017348165 cites W2033088300 @default.
- W2017348165 cites W2035242925 @default.
- W2017348165 cites W2035696265 @default.
- W2017348165 cites W2036556119 @default.
- W2017348165 cites W2037174379 @default.
- W2017348165 cites W2037755817 @default.
- W2017348165 cites W2038503730 @default.
- W2017348165 cites W2038773696 @default.
- W2017348165 cites W2039799680 @default.
- W2017348165 cites W2041480611 @default.
- W2017348165 cites W2041766211 @default.
- W2017348165 cites W2041865050 @default.
- W2017348165 cites W2042469661 @default.
- W2017348165 cites W2044000768 @default.
- W2017348165 cites W2044953211 @default.
- W2017348165 cites W2046712927 @default.
- W2017348165 cites W2047334057 @default.
- W2017348165 cites W2049907045 @default.
- W2017348165 cites W2053342448 @default.
- W2017348165 cites W2055019305 @default.
- W2017348165 cites W2055316800 @default.
- W2017348165 cites W2055361189 @default.
- W2017348165 cites W2056209478 @default.
- W2017348165 cites W2062013622 @default.
- W2017348165 cites W2063728474 @default.
- W2017348165 cites W2063795634 @default.
- W2017348165 cites W2065990895 @default.
- W2017348165 cites W2067042828 @default.
- W2017348165 cites W2067581223 @default.
- W2017348165 cites W2067870418 @default.
- W2017348165 cites W2068780189 @default.
- W2017348165 cites W2071823815 @default.
- W2017348165 cites W2071862575 @default.
- W2017348165 cites W2074830311 @default.
- W2017348165 cites W2075095085 @default.
- W2017348165 cites W2076653117 @default.