Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017349625> ?p ?o ?g. }
- W2017349625 endingPage "8584" @default.
- W2017349625 startingPage "8576" @default.
- W2017349625 abstract "Grafted macromolecules often induce granuloma formation with foreign body giant cell (FBGC) infiltration, and this is the main reason for graft failure. Diacylglycerol kinase (DAGK) is an important intracellular mediator of FBGC formation in macrophages. In this study, 4-hexylresorcinol (4HR) inhibited DAGKδ in a macrophage cell line (RAW264.7 cells). As a result of DAGK-δ inhibition by 4HR, FBGC formation was significantly inhibited in RAW264.7 cells. Silk fibroin is a well-known natural macromolecule, and when it is grafted into bone defects, it results in granuloma formation with massive FBGC formation. 4HR-incorporating silk graft materials displayed significant reduction of granuloma formation and increases in the extent of new bone formation in a rabbit calvarial defect model. In conclusion, 4HR could inhibit foreign body reaction via a DAGK-mediated pathway." @default.
- W2017349625 created "2016-06-24" @default.
- W2017349625 creator A5019860923 @default.
- W2017349625 creator A5045021415 @default.
- W2017349625 creator A5080573103 @default.
- W2017349625 date "2014-10-01" @default.
- W2017349625 modified "2023-09-26" @default.
- W2017349625 title "Inhibition of foreign body giant cell formation by 4- hexylresorcinol through suppression of diacylglycerol kinase delta gene expression" @default.
- W2017349625 cites W1512269824 @default.
- W2017349625 cites W1969229361 @default.
- W2017349625 cites W1971219606 @default.
- W2017349625 cites W1973524282 @default.
- W2017349625 cites W1978640748 @default.
- W2017349625 cites W1980429658 @default.
- W2017349625 cites W1981046910 @default.
- W2017349625 cites W1982858761 @default.
- W2017349625 cites W1986577550 @default.
- W2017349625 cites W1996193561 @default.
- W2017349625 cites W2002959031 @default.
- W2017349625 cites W2003832763 @default.
- W2017349625 cites W2006725349 @default.
- W2017349625 cites W2007901852 @default.
- W2017349625 cites W2016764440 @default.
- W2017349625 cites W2022071421 @default.
- W2017349625 cites W2032478134 @default.
- W2017349625 cites W2041223966 @default.
- W2017349625 cites W2044045324 @default.
- W2017349625 cites W2049929455 @default.
- W2017349625 cites W2050362957 @default.
- W2017349625 cites W2051651031 @default.
- W2017349625 cites W2052261499 @default.
- W2017349625 cites W2056223696 @default.
- W2017349625 cites W2059574576 @default.
- W2017349625 cites W2061609938 @default.
- W2017349625 cites W2064798813 @default.
- W2017349625 cites W2071376475 @default.
- W2017349625 cites W2073653635 @default.
- W2017349625 cites W2073745933 @default.
- W2017349625 cites W2082515354 @default.
- W2017349625 cites W2086801771 @default.
- W2017349625 cites W2094191621 @default.
- W2017349625 cites W2100837269 @default.
- W2017349625 cites W2109934888 @default.
- W2017349625 cites W2110983476 @default.
- W2017349625 cites W2141319880 @default.
- W2017349625 cites W2152311269 @default.
- W2017349625 cites W2157134073 @default.
- W2017349625 cites W2164031736 @default.
- W2017349625 cites W2335489080 @default.
- W2017349625 cites W2091995599 @default.
- W2017349625 doi "https://doi.org/10.1016/j.biomaterials.2014.06.050" @default.
- W2017349625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25023393" @default.
- W2017349625 hasPublicationYear "2014" @default.
- W2017349625 type Work @default.
- W2017349625 sameAs 2017349625 @default.
- W2017349625 citedByCount "36" @default.
- W2017349625 countsByYear W20173496252014 @default.
- W2017349625 countsByYear W20173496252015 @default.
- W2017349625 countsByYear W20173496252016 @default.
- W2017349625 countsByYear W20173496252017 @default.
- W2017349625 countsByYear W20173496252018 @default.
- W2017349625 countsByYear W20173496252019 @default.
- W2017349625 countsByYear W20173496252020 @default.
- W2017349625 countsByYear W20173496252021 @default.
- W2017349625 countsByYear W20173496252022 @default.
- W2017349625 crossrefType "journal-article" @default.
- W2017349625 hasAuthorship W2017349625A5019860923 @default.
- W2017349625 hasAuthorship W2017349625A5045021415 @default.
- W2017349625 hasAuthorship W2017349625A5080573103 @default.
- W2017349625 hasConcept C108657112 @default.
- W2017349625 hasConcept C142724271 @default.
- W2017349625 hasConcept C159985019 @default.
- W2017349625 hasConcept C184235292 @default.
- W2017349625 hasConcept C185592680 @default.
- W2017349625 hasConcept C192562407 @default.
- W2017349625 hasConcept C195794163 @default.
- W2017349625 hasConcept C2780431358 @default.
- W2017349625 hasConcept C36020004 @default.
- W2017349625 hasConcept C71924100 @default.
- W2017349625 hasConcept C77076574 @default.
- W2017349625 hasConcept C86803240 @default.
- W2017349625 hasConcept C95444343 @default.
- W2017349625 hasConceptScore W2017349625C108657112 @default.
- W2017349625 hasConceptScore W2017349625C142724271 @default.
- W2017349625 hasConceptScore W2017349625C159985019 @default.
- W2017349625 hasConceptScore W2017349625C184235292 @default.
- W2017349625 hasConceptScore W2017349625C185592680 @default.
- W2017349625 hasConceptScore W2017349625C192562407 @default.
- W2017349625 hasConceptScore W2017349625C195794163 @default.
- W2017349625 hasConceptScore W2017349625C2780431358 @default.
- W2017349625 hasConceptScore W2017349625C36020004 @default.
- W2017349625 hasConceptScore W2017349625C71924100 @default.
- W2017349625 hasConceptScore W2017349625C77076574 @default.
- W2017349625 hasConceptScore W2017349625C86803240 @default.
- W2017349625 hasConceptScore W2017349625C95444343 @default.
- W2017349625 hasIssue "30" @default.
- W2017349625 hasLocation W20173496251 @default.
- W2017349625 hasLocation W20173496252 @default.