FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017350087> ?p ?o ?g. }

• W2017350087 endingPage "34064" @default.
• W2017350087 startingPage "34054" @default.
• W2017350087 abstract "Apoptosis and proliferation are two dynamically and tightly regulated processes that together maintain the homeostasis of renewable tissues. Anoikis is a subtype of apoptosis induced by detachment of adherent cells from the extracellular matrix. By using the defined mTeSR1 medium and collecting freshly detached cells, we found here that human pluripotent stem (PS) cells including embryonic stem (ES) cells and induced pluripotent stem cells are subject to constant anoikis in culture, which is escalated in the absence of basic fibroblast growth factor (bFGF). Withdrawal of bFGF also promotes apoptosis and differentiation of the remaining adherent cells without affecting their cell cycle progression. Insulin-like growth factor 2 (IGF2) has previously been reported to act downstream of FGF signaling to support self-renewal of human ES cells. However, we found that IGF2 cannot substitute bFGF in the TeSR1-supported culture, although endogenous IGF signaling is required to sustain self-renewal of human ES cells. On the other hand, all of the bFGF withdrawal effects observed here can be markedly prevented by the caspase inhibitor z-VAD-FMK. We further demonstrated that the bFGF-repressed anoikis is dependent on activation of ERK and AKT and associated with inhibition of Bcl-2-interacting mediator of cell death and the caspase-ROCK1-myosin signaling. Anoikis is independent of pre-detachment apoptosis and differentiation of the cells. Because previous studies of human PS cells have been focused on attached cells, our findings revealed a neglected role of bFGF in sustaining self-renewal of human PS cells: preventing them from anoikis via inhibition of caspase activation." @default.
• W2017350087 created "2016-06-24" @default.
• W2017350087 creator A5002156862 @default.
• W2017350087 creator A5007013151 @default.
• W2017350087 creator A5019571170 @default.
• W2017350087 creator A5070558214 @default.
• W2017350087 creator A5071030446 @default.
• W2017350087 date "2009-12-01" @default.
• W2017350087 modified "2023-10-15" @default.
• W2017350087 title "Inhibition of Caspase-mediated Anoikis Is Critical for Basic Fibroblast Growth Factor-sustained Culture of Human Pluripotent Stem Cells" @default.
• W2017350087 cites W1599568627 @default.
• W2017350087 cites W1976628761 @default.
• W2017350087 cites W1982960471 @default.
• W2017350087 cites W1985263934 @default.
• W2017350087 cites W1994758141 @default.
• W2017350087 cites W1996903810 @default.
• W2017350087 cites W1996989584 @default.
• W2017350087 cites W2004128999 @default.
• W2017350087 cites W2006557127 @default.
• W2017350087 cites W2010188939 @default.
• W2017350087 cites W2013464231 @default.
• W2017350087 cites W2022601518 @default.
• W2017350087 cites W2029962300 @default.
• W2017350087 cites W2032238268 @default.
• W2017350087 cites W2038723730 @default.
• W2017350087 cites W2055156816 @default.
• W2017350087 cites W2056089399 @default.
• W2017350087 cites W2060299616 @default.
• W2017350087 cites W2067163479 @default.
• W2017350087 cites W2073212505 @default.
• W2017350087 cites W2075757507 @default.
• W2017350087 cites W2076534093 @default.
• W2017350087 cites W2081245863 @default.
• W2017350087 cites W2081994535 @default.
• W2017350087 cites W2082292567 @default.
• W2017350087 cites W2083186952 @default.
• W2017350087 cites W2086943348 @default.
• W2017350087 cites W2087367624 @default.
• W2017350087 cites W2094146976 @default.
• W2017350087 cites W2110301828 @default.
• W2017350087 cites W2112104218 @default.
• W2017350087 cites W2126432370 @default.
• W2017350087 cites W2128094400 @default.
• W2017350087 cites W2133501984 @default.
• W2017350087 cites W2138977668 @default.
• W2017350087 cites W2142046859 @default.
• W2017350087 cites W2145139438 @default.
• W2017350087 cites W2151501496 @default.
• W2017350087 cites W4247033596 @default.
• W2017350087 cites W4247467967 @default.
• W2017350087 cites W4251667769 @default.
• W2017350087 cites W73980168 @default.
• W2017350087 doi "https://doi.org/10.1074/jbc.m109.052290" @default.
• W2017350087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2797176" @default.
• W2017350087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19828453" @default.
• W2017350087 hasPublicationYear "2009" @default.
• W2017350087 type Work @default.
• W2017350087 sameAs 2017350087 @default.
• W2017350087 citedByCount "64" @default.
• W2017350087 countsByYear W20173500872012 @default.
• W2017350087 countsByYear W20173500872013 @default.
• W2017350087 countsByYear W20173500872014 @default.
• W2017350087 countsByYear W20173500872015 @default.
• W2017350087 countsByYear W20173500872016 @default.
• W2017350087 countsByYear W20173500872017 @default.
• W2017350087 countsByYear W20173500872018 @default.
• W2017350087 countsByYear W20173500872019 @default.
• W2017350087 countsByYear W20173500872020 @default.
• W2017350087 countsByYear W20173500872022 @default.
• W2017350087 crossrefType "journal-article" @default.
• W2017350087 hasAuthorship W2017350087A5002156862 @default.
• W2017350087 hasAuthorship W2017350087A5007013151 @default.
• W2017350087 hasAuthorship W2017350087A5019571170 @default.
• W2017350087 hasAuthorship W2017350087A5070558214 @default.
• W2017350087 hasAuthorship W2017350087A5071030446 @default.
• W2017350087 hasBestOaLocation W20173500871 @default.
• W2017350087 hasConcept C104317684 @default.
• W2017350087 hasConcept C107459253 @default.
• W2017350087 hasConcept C145103041 @default.
• W2017350087 hasConcept C152000582 @default.
• W2017350087 hasConcept C170493617 @default.
• W2017350087 hasConcept C190283241 @default.
• W2017350087 hasConcept C2775960820 @default.
• W2017350087 hasConcept C2777587049 @default.
• W2017350087 hasConcept C28328180 @default.
• W2017350087 hasConcept C31573885 @default.
• W2017350087 hasConcept C55493867 @default.
• W2017350087 hasConcept C74373430 @default.
• W2017350087 hasConcept C86803240 @default.
• W2017350087 hasConcept C95444343 @default.
• W2017350087 hasConceptScore W2017350087C104317684 @default.
• W2017350087 hasConceptScore W2017350087C107459253 @default.
• W2017350087 hasConceptScore W2017350087C145103041 @default.
• W2017350087 hasConceptScore W2017350087C152000582 @default.
• W2017350087 hasConceptScore W2017350087C170493617 @default.
• W2017350087 hasConceptScore W2017350087C190283241 @default.
• W2017350087 hasConceptScore W2017350087C2775960820 @default.
• W2017350087 hasConceptScore W2017350087C2777587049 @default.

• next