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- W2017351649 abstract "Numerous noninvasive techniques have been examined for the detection of acute rejection following cardiac transplantation, but none has proven sufficiently sensitive to replace the endomyocardial biopsy. A prospective study was performed in 92 heart transplant patients in order to test the hypothesis that mitral regurgitant ratio by two-dimensional echocardiography with Doppler flow mapping could detect moderate or severe acute allograft rejection. There were 82 rejection episodes identified, of which 40% were associated with mitral regurgitation by echo-Doppler at the beginning of the episode. With augmentation of immunosuppression during a rejection episode, there was a progressive fall in the degree of mitral incompetence (P = 0.03). The sensitivity of color Doppler studies in identifying rejection was low (60% of all rejection episodes had no associated mitral incompetence at the beginning of the episode), but the likelihood of rejection progressively increased with higher degrees of mitral regurgitation (P < 0.01), approaching 60% when the echo-Doppler regurgitant ratio exceeded 15%. Echo-Doppler studies do not provide sufficient sensitivity to be useful as a screening technique for acute cardiac rejection, but high or increasing echocardiographic mitral regurgitant ratio is predictive of acute rejection and should indicate prompt endomyocardial biopsy." @default.
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- W2017351649 date "1992-03-01" @default.
- W2017351649 modified "2023-10-16" @default.
- W2017351649 title "Application of Echocardiographic Color Flow Doppler Mitral Regurgitation to the Diagnosis of Acute Cardiac Transplant Rejection" @default.
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- W2017351649 doi "https://doi.org/10.1111/j.1540-8175.1992.tb00455.x" @default.
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