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- W2017354476 startingPage "1709" @default.
- W2017354476 abstract "Platelets are megakaryocyte-derived anucleated cells found in the blood. They are mainly responsible for rendering hemostasis or clotting to prevent bleeding complications. Decreased platelet numbers or deficiencies in platelet functions can lead to various acute or chronic bleeding conditions and hemorrhage. On the other hand, dysregulated hyperactivity of the clotting process can lead to thrombosis and vascular occlusion. There is significant evidence that beyond hemostasis and thrombosis, platelets play crucial mechanistic roles in other disease scenarios such as inflammation, immune response and cancer metastasis by mediating several cell-cell and cell-matrix interactions, as well as aiding the disease microenvironment via secretion of multiple soluble factors. Therefore, elucidating these mechanistic functions of platelets can provide unique avenues for developing platelet-inspired nanomedicine strategies targeted to these diseases. To this end, the current review provides detailed mechanistic insight into platelets' disease-relevant functions and discusses how these mechanisms can be utilized to engineer targeted nanomedicine systems." @default.
- W2017354476 created "2016-06-24" @default.
- W2017354476 creator A5026152469 @default.
- W2017354476 creator A5039513851 @default.
- W2017354476 creator A5062301447 @default.
- W2017354476 creator A5070140867 @default.
- W2017354476 date "2013-10-01" @default.
- W2017354476 modified "2023-09-25" @default.
- W2017354476 title "A platelet-inspired paradigm for nanomedicine targeted to multiple diseases" @default.
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