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- W2017356695 abstract "Evaluation of: Stevenson PG, May JS, Connor V, Efstathiou S: Vaccination against a hit-and-run viral cancer. J. Gen. Virol. 91, 2176–2185 (2010). Viral hit-and-run oncogenesis scenarios suggest that transient acquisition of viral genomes can induce a permanent change in the gene expression pattern of the host cell, resulting in malignant conversion. Stevenson et al. developed an in vivo model system based on the introduction of a Cre-recombinase positive murid herpesvirus into genetically engineered mice. They demonstrated that the Cre recombinase could switch on a silent oncogene and inactivate a tumor suppressor gene resulting in sarcomagenesis. However, some of the tumors lacked herpesvirus genomes, suggesting a hit-and-run type oncogenesis. The authors also observed that vaccination could prevent sarcomagenesis in their model." @default.
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- W2017356695 date "2011-01-01" @default.
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- W2017356695 title "Viral hit-and-run tumorigenesis" @default.
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- W2017356695 doi "https://doi.org/10.2217/fvl.10.72" @default.
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