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- W2017358001 abstract "Depression is among the most common psychiatric disorders, and in many patients a disorder for which available medications provide suboptimal or no symptom relief. The most commonly prescribed class of antidepressants, the selective serotonin reuptake inhibitors (SSRIs), are thought to act by increasing extracellular serotonin in brain by blocking its uptake via the high-affinity serotonin transporter (SERT). However, the relative lack of therapeutic efficacy of SSRIs has brought into question the utility of increasing extracellular serotonin for the treatment of depression. In this Viewpoint, we discuss why increasing extracellular serotonin should not be written off as a therapeutic strategy. We describe how uptake-2 transporters may explain the relative lack of therapeutic efficacy of SSRIs, as well as why uptake-2 transporters might be useful therapeutic targets." @default.
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- W2017358001 date "2013-01-16" @default.
- W2017358001 modified "2023-09-25" @default.
- W2017358001 title "Revisiting Serotonin Reuptake Inhibitors and the Therapeutic Potential of “Uptake-2” in Psychiatric Disorders" @default.
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- W2017358001 doi "https://doi.org/10.1021/cn3001872" @default.
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