FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017360401> ?p ?o ?g. }

• W2017360401 endingPage "390" @default.
• W2017360401 startingPage "381" @default.
• W2017360401 abstract "White Pekin ducks (three in each of four groups) received trinitrofluorobenzene (TNP) conjugated to keyhole limpet haemocyanin (KLH) or human immunoglobulin G (HIgG) either incorporated into adjuvants (complete Freund's adjuvant (CFA), then incomplete Freund's adjuvant (IFA) followed by intravenous (i.v.) injection) or by repeated i.v. injection. A rabbit received TNP-KLH with CFA, IFA, then i.v. Antibody (Ab) responses to the carrier proteins and to the TNP hapten were monitored by enzyme-linked immunosorbent assay (ELISA), optimized for use with duck Abs, and the response to TNP was also assessed in an ELISA designed to detect shifts in Ab affinity (Ka). The rabbit mounted good Ab responses to KLH and TNP, the Ka of the anti-TNP response increasing from 105.99 to 108.87 l/mol (758-fold) during the experiment. Ducks showed weak Ab responses to KLH and HIgG, with weakest responses among ducks receiving antigen by the i.v. route exclusively. The duck anti-TNP responses were vigorous in all cases. However, following i.v. administration of antigens (Ags), the anti-TNP responses were transient, being strong by 7 days but diminishing to background levels by 14 to 28 days after each inoculation. The duck Ab responses to TNP displayed affinity maturation. In ducks receiving Ags with adjuvants, Ka increased by levels comparable with or even exceeding those in the rabbit. Affinity increases were less, but nevertheless apparent, following i.v. administration of Ag. These results show that, contrary to expectation, the duck Ab response experiences affinity maturation. They also point to the transience of the duck Ab response to selected haptens/epitopes when Ag is not delivered in adjuvant. These findings have clinical implications for field responses to pathogens and vaccines." @default.
• W2017360401 created "2016-06-24" @default.
• W2017360401 creator A5001501110 @default.
• W2017360401 creator A5048558639 @default.
• W2017360401 creator A5091492576 @default.
• W2017360401 date "2001-08-01" @default.
• W2017360401 modified "2023-10-18" @default.
• W2017360401 title "Duck antibody responses to keyhole limpet haemocyanin, human immunoglobulin G and the trinitrophenyl hapten. Evidence of affinity maturation" @default.
• W2017360401 cites W1538475960 @default.
• W2017360401 cites W1812448809 @default.
• W2017360401 cites W1834379353 @default.
• W2017360401 cites W1841497788 @default.
• W2017360401 cites W1922210072 @default.
• W2017360401 cites W1972805951 @default.
• W2017360401 cites W1974257409 @default.
• W2017360401 cites W1981197474 @default.
• W2017360401 cites W2011785191 @default.
• W2017360401 cites W2014549199 @default.
• W2017360401 cites W2025467045 @default.
• W2017360401 cites W2031263707 @default.
• W2017360401 cites W2034094261 @default.
• W2017360401 cites W2044649130 @default.
• W2017360401 cites W2047554700 @default.
• W2017360401 cites W2050188367 @default.
• W2017360401 cites W2068747743 @default.
• W2017360401 cites W2076179722 @default.
• W2017360401 cites W2104008372 @default.
• W2017360401 cites W2153593191 @default.
• W2017360401 cites W2162087337 @default.
• W2017360401 cites W2327105058 @default.
• W2017360401 cites W2333339764 @default.
• W2017360401 cites W2335451972 @default.
• W2017360401 cites W4313310281 @default.
• W2017360401 cites W4313376960 @default.
• W2017360401 cites W4313376961 @default.
• W2017360401 cites W4320304072 @default.
• W2017360401 doi "https://doi.org/10.1080/03079450120066386" @default.
• W2017360401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19184923" @default.
• W2017360401 hasPublicationYear "2001" @default.
• W2017360401 type Work @default.
• W2017360401 sameAs 2017360401 @default.
• W2017360401 citedByCount "11" @default.
• W2017360401 countsByYear W20173604012017 @default.
• W2017360401 countsByYear W20173604012019 @default.
• W2017360401 countsByYear W20173604012020 @default.
• W2017360401 countsByYear W20173604012021 @default.
• W2017360401 countsByYear W20173604012023 @default.
• W2017360401 crossrefType "journal-article" @default.
• W2017360401 hasAuthorship W2017360401A5001501110 @default.
• W2017360401 hasAuthorship W2017360401A5048558639 @default.
• W2017360401 hasAuthorship W2017360401A5091492576 @default.
• W2017360401 hasConcept C147483822 @default.
• W2017360401 hasConcept C153911025 @default.
• W2017360401 hasConcept C159654299 @default.
• W2017360401 hasConcept C203014093 @default.
• W2017360401 hasConcept C2776727803 @default.
• W2017360401 hasConcept C2777863537 @default.
• W2017360401 hasConcept C2779915011 @default.
• W2017360401 hasConcept C29144244 @default.
• W2017360401 hasConcept C86803240 @default.
• W2017360401 hasConceptScore W2017360401C147483822 @default.
• W2017360401 hasConceptScore W2017360401C153911025 @default.
• W2017360401 hasConceptScore W2017360401C159654299 @default.
• W2017360401 hasConceptScore W2017360401C203014093 @default.
• W2017360401 hasConceptScore W2017360401C2776727803 @default.
• W2017360401 hasConceptScore W2017360401C2777863537 @default.
• W2017360401 hasConceptScore W2017360401C2779915011 @default.
• W2017360401 hasConceptScore W2017360401C29144244 @default.
• W2017360401 hasConceptScore W2017360401C86803240 @default.
• W2017360401 hasIssue "4" @default.
• W2017360401 hasLocation W20173604011 @default.
• W2017360401 hasLocation W20173604012 @default.
• W2017360401 hasOpenAccess W2017360401 @default.
• W2017360401 hasPrimaryLocation W20173604011 @default.
• W2017360401 hasRelatedWork W1549724320 @default.
• W2017360401 hasRelatedWork W1559750577 @default.
• W2017360401 hasRelatedWork W1617229007 @default.
• W2017360401 hasRelatedWork W2013671168 @default.
• W2017360401 hasRelatedWork W2017360401 @default.
• W2017360401 hasRelatedWork W2061347790 @default.
• W2017360401 hasRelatedWork W2070007118 @default.
• W2017360401 hasRelatedWork W2107063503 @default.
• W2017360401 hasRelatedWork W2399963719 @default.
• W2017360401 hasRelatedWork W2994077801 @default.
• W2017360401 hasVolume "30" @default.
• W2017360401 isParatext "false" @default.
• W2017360401 isRetracted "false" @default.
• W2017360401 magId "2017360401" @default.
• W2017360401 workType "article" @default.