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• W2017361318 endingPage "271" @default.
• W2017361318 startingPage "257" @default.
• W2017361318 abstract "This Review discusses recent studies that have identified inositol-1,3,4,5-tetrakisphosphate as a soluble messenger molecule that is essential for the development and function of T cells, B cells and neutrophils through regulating phosphoinositide 3-kinase function and Ca2+mobilization. The membrane lipid phosphatidylinositol-3,4,5-trisphosphate (PtdInsP3) regulates membrane receptor signalling in many cells, including immunoreceptor signalling. Here, we review recent data that have indicated essential roles for the soluble PtdInsP3 analogue inositol-1,3,4,5-tetrakisphosphate (InsP4) in T cell, B cell and neutrophil development and function. Decreased InsP4 production in leukocytes causes immunodeficiency in mice and might contribute to inflammatory vasculitis in Kawasaki disease in humans. InsP4-producing kinases could therefore provide attractive drug targets for inflammatory and infectious diseases." @default.
• W2017361318 created "2016-06-24" @default.
• W2017361318 creator A5040518837 @default.
• W2017361318 creator A5082196069 @default.
• W2017361318 date "2010-04-01" @default.
• W2017361318 modified "2023-09-27" @default.
• W2017361318 title "Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate" @default.
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