FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017363150> ?p ?o ?g. }

• W2017363150 endingPage "482" @default.
• W2017363150 startingPage "475" @default.
• W2017363150 abstract "ObjectivesWe sought to evaluate whether there is variability in blood dexamethasone levels after a standard 1 mg/kg dose of dexamethasone administered before infant cardiopulmonary bypass. We hypothesized that postoperative dexamethasone drug levels are highly variable, and that the infant stress response is related inversely to the amount of dexamethasone measured in the blood.MethodsThirty-two infants (age, ≤365 days) received 1 mg/kg of dexamethasone before cardiopulmonary bypass (CPB) initiation. Blood was analyzed for cortisol, adrenocorticotropin, and interleukin (IL)-6, IL-8, and IL-10 levels after anesthesia induction, after CPB, after intensive care unit (ICU) arrival, and 4, 8, 12, and 24 hours after surgery. Patients were grouped as high dexamethasone (≥15 μg/dL) or low dexamethasone (<15 μg/dL) based on their level at ICU arrival.ResultsDexamethasone levels varied significantly between the high (n = 22) and low (n = 10) dexamethasone groups throughout the entire postoperative course and were correlated highly with cortisol response. Patients with high dexamethasone levels had postoperative cortisol levels that were lower than their pre-CPB baseline cortisol levels. Cortisol levels remained low throughout the first 24 postoperative hours even after dexamethasone levels neared zero. There were no significant differences between groups in the duration of mechanical ventilation or ICU length of stay.ConclusionsDexamethasone levels are highly variable at ICU arrival, despite standardized 1 mg/kg dosing before CPB initiation. We sought to evaluate whether there is variability in blood dexamethasone levels after a standard 1 mg/kg dose of dexamethasone administered before infant cardiopulmonary bypass. We hypothesized that postoperative dexamethasone drug levels are highly variable, and that the infant stress response is related inversely to the amount of dexamethasone measured in the blood. Thirty-two infants (age, ≤365 days) received 1 mg/kg of dexamethasone before cardiopulmonary bypass (CPB) initiation. Blood was analyzed for cortisol, adrenocorticotropin, and interleukin (IL)-6, IL-8, and IL-10 levels after anesthesia induction, after CPB, after intensive care unit (ICU) arrival, and 4, 8, 12, and 24 hours after surgery. Patients were grouped as high dexamethasone (≥15 μg/dL) or low dexamethasone (<15 μg/dL) based on their level at ICU arrival. Dexamethasone levels varied significantly between the high (n = 22) and low (n = 10) dexamethasone groups throughout the entire postoperative course and were correlated highly with cortisol response. Patients with high dexamethasone levels had postoperative cortisol levels that were lower than their pre-CPB baseline cortisol levels. Cortisol levels remained low throughout the first 24 postoperative hours even after dexamethasone levels neared zero. There were no significant differences between groups in the duration of mechanical ventilation or ICU length of stay. Dexamethasone levels are highly variable at ICU arrival, despite standardized 1 mg/kg dosing before CPB initiation." @default.
• W2017363150 created "2016-06-24" @default.
• W2017363150 creator A5002295054 @default.
• W2017363150 creator A5017671795 @default.
• W2017363150 creator A5023330411 @default.
• W2017363150 creator A5045312242 @default.
• W2017363150 creator A5057613002 @default.
• W2017363150 creator A5070869742 @default.
• W2017363150 creator A5088121978 @default.
• W2017363150 date "2014-01-01" @default.
• W2017363150 modified "2023-09-27" @default.
• W2017363150 title "Dexamethasone levels predict cortisol response after infant cardiopulmonary bypass" @default.
• W2017363150 cites W1517519529 @default.
• W2017363150 cites W1970415588 @default.
• W2017363150 cites W1980207652 @default.
• W2017363150 cites W1982082299 @default.
• W2017363150 cites W1983594459 @default.
• W2017363150 cites W2021849468 @default.
• W2017363150 cites W2024894120 @default.
• W2017363150 cites W2027619699 @default.
• W2017363150 cites W2039952901 @default.
• W2017363150 cites W2046234412 @default.
• W2017363150 cites W2053272815 @default.
• W2017363150 cites W2056596224 @default.
• W2017363150 cites W2057914783 @default.
• W2017363150 cites W2089937577 @default.
• W2017363150 cites W2119666961 @default.
• W2017363150 cites W2122620245 @default.
• W2017363150 cites W2395016842 @default.
• W2017363150 doi "https://doi.org/10.1016/j.jtcvs.2013.09.023" @default.
• W2017363150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24210831" @default.
• W2017363150 hasPublicationYear "2014" @default.
• W2017363150 type Work @default.
• W2017363150 sameAs 2017363150 @default.
• W2017363150 citedByCount "8" @default.
• W2017363150 countsByYear W20173631502014 @default.
• W2017363150 countsByYear W20173631502015 @default.
• W2017363150 countsByYear W20173631502016 @default.
• W2017363150 countsByYear W20173631502017 @default.
• W2017363150 countsByYear W20173631502018 @default.
• W2017363150 countsByYear W20173631502019 @default.
• W2017363150 countsByYear W20173631502020 @default.
• W2017363150 crossrefType "journal-article" @default.
• W2017363150 hasAuthorship W2017363150A5002295054 @default.
• W2017363150 hasAuthorship W2017363150A5017671795 @default.
• W2017363150 hasAuthorship W2017363150A5023330411 @default.
• W2017363150 hasAuthorship W2017363150A5045312242 @default.
• W2017363150 hasAuthorship W2017363150A5057613002 @default.
• W2017363150 hasAuthorship W2017363150A5070869742 @default.
• W2017363150 hasAuthorship W2017363150A5088121978 @default.
• W2017363150 hasBestOaLocation W20173631501 @default.
• W2017363150 hasConcept C126322002 @default.
• W2017363150 hasConcept C2776376669 @default.
• W2017363150 hasConcept C2776804153 @default.
• W2017363150 hasConcept C2777080012 @default.
• W2017363150 hasConcept C2777288759 @default.
• W2017363150 hasConcept C2778709874 @default.
• W2017363150 hasConcept C2778881276 @default.
• W2017363150 hasConcept C2780401358 @default.
• W2017363150 hasConcept C2780841215 @default.
• W2017363150 hasConcept C42219234 @default.
• W2017363150 hasConcept C71924100 @default.
• W2017363150 hasConceptScore W2017363150C126322002 @default.
• W2017363150 hasConceptScore W2017363150C2776376669 @default.
• W2017363150 hasConceptScore W2017363150C2776804153 @default.
• W2017363150 hasConceptScore W2017363150C2777080012 @default.
• W2017363150 hasConceptScore W2017363150C2777288759 @default.
• W2017363150 hasConceptScore W2017363150C2778709874 @default.
• W2017363150 hasConceptScore W2017363150C2778881276 @default.
• W2017363150 hasConceptScore W2017363150C2780401358 @default.
• W2017363150 hasConceptScore W2017363150C2780841215 @default.
• W2017363150 hasConceptScore W2017363150C42219234 @default.
• W2017363150 hasConceptScore W2017363150C71924100 @default.
• W2017363150 hasIssue "1" @default.
• W2017363150 hasLocation W20173631501 @default.
• W2017363150 hasLocation W20173631502 @default.
• W2017363150 hasOpenAccess W2017363150 @default.
• W2017363150 hasPrimaryLocation W20173631501 @default.
• W2017363150 hasRelatedWork W1966919723 @default.
• W2017363150 hasRelatedWork W1976035881 @default.
• W2017363150 hasRelatedWork W2041942526 @default.
• W2017363150 hasRelatedWork W2066225521 @default.
• W2017363150 hasRelatedWork W2080960184 @default.
• W2017363150 hasRelatedWork W2084912383 @default.
• W2017363150 hasRelatedWork W2115748452 @default.
• W2017363150 hasRelatedWork W2319040444 @default.
• W2017363150 hasRelatedWork W4206912177 @default.
• W2017363150 hasRelatedWork W4375845104 @default.
• W2017363150 hasVolume "147" @default.
• W2017363150 isParatext "false" @default.
• W2017363150 isRetracted "false" @default.
• W2017363150 magId "2017363150" @default.
• W2017363150 workType "article" @default.