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• W2017363422 abstract "To take a comprehensive evaluation of the bio-safety of doxorubicin-loaded superparamagnetic iron oxide nanoparticles (SPION), the interaction of bovine serum albumin (BSA) with the drug delivery was investigated by multi-spectroscopic techniques and molecular modelling calculation. Ultraviolet absorption and synchronous fluorescence results elucidate that DOX-SPION unfold the framework conformation of BSA, leading to changes in the microenvironment of amide moieties. Circular dichroism (CD) data show that the content of α-helix decreases from 68.62% to 62.76%, which shows the changes of protein's secondary structure quantificationally. Through Stern-Volmer analysis, the quenching mode is determined to be static interaction, forming a stable bioconjugate. The molecular model illustrates that DOX prefers a highly polar binding site at the external region of domains □ of BSA, and the hydrogen bonds are marked. This work elucidates that the drug delivery has deleterious effects on the frame conformation of protein, affecting its physiological function." @default.
• W2017363422 created "2016-06-24" @default.
• W2017363422 creator A5023480295 @default.
• W2017363422 creator A5027336778 @default.
• W2017363422 creator A5030456344 @default.
• W2017363422 date "2011-11-17" @default.
• W2017363422 modified "2023-10-08" @default.
• W2017363422 title "The interaction of bovine serum albumin with doxorubicin-loaded superparamagnetic iron oxide nanoparticles: spectroscope and molecular modelling identification" @default.
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• W2017363422 doi "https://doi.org/10.3109/17435390.2011.634079" @default.
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