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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017363602> ?p ?o ?g. }

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• W2017363602 abstract "Disalicylic acid derivatives with stilbene and bis-styrylbenzene skeleton were synthesized as PTP1B inhibitors. The most potent in this series exhibited a submicromolar IC(50) value. One of the compounds 7b was tested in an animal model for its efficacy as an anti-diabetic or an anti-obesity agent. In feeding compound 7b to diet-induced obese mice, no significant differences in weight gain and food consumption were observed between the drug-treated and the obese control mice. However, 7b significantly lowered the fasting glucose level and improved the glucose tolerance in the obesity-induced diabetic mice." @default.
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• W2017363602 date "2008-09-01" @default.
• W2017363602 modified "2023-10-03" @default.
• W2017363602 title "Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity" @default.
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• W2017363602 doi "https://doi.org/10.1016/j.bmc.2008.07.090" @default.
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