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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017364006> ?p ?o ?g. }

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• W2017364006 abstract "The α subunit (G sα ) of the stimulatory heterotrimeric guanosine triphosphate binding protein (G protein) G s activates all isoforms of mammalian adenylyl cyclase. Adenylyl cyclase (Type V) and its subdomains, which interact with G sα , promoted inactivation of the G protein by increasing its guanosine triphosphatase (GTPase) activity. Adenylyl cyclase and its subdomains also augmented the receptor-mediated activation of heterotrimeric G s and thereby facilitated the rapid onset of signaling. These findings demonstrate that adenylyl cyclase functions as a GTPase activating protein (GAP) for the monomeric G sα and enhances the GTP/GDP exchange factor (GEF) activity of receptors." @default.
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• W2017364006 date "1999-02-26" @default.
• W2017364006 modified "2023-09-23" @default.
• W2017364006 title "Facilitation of Signal Onset and Termination by Adenylyl Cyclase" @default.
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• W2017364006 doi "https://doi.org/10.1126/science.283.5406.1328" @default.
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