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- W2017366933 abstract "Abstract 1. 1. The predominant effect of salmon calcitonin (SCT) on frogs was hyperphosphatemic; only at 1μU/g body wt (doses, 0.5μU-20mU/g body wt) was any hypophosphatemia noted. In temporal studies, a hyperphosphatemia of high magnitude appeared at 3.5–15 min. SCT-treated rats were hypophosphatemic after a transient hyperphosphatemia. 2. 2. Only at 1 μU SCT/g body wt were R. pipiens hypocalcemic. In temporal studies, an early hypocalcemia (7.5–15 min) was followed by a hypercalcemia. possibly due to a secondary hyperparathyroidism. SCT-treated X. laevis remained normocalcemic. SCT-treated rats were typically hypocalcemic after a transient hypercalcemia. 3. 3. Plasma mineral levels and fractional volumes (PFV; percentage of whole blood representing plasma) were reciprocal; high mineral titers were associated with low PFV, and the converse. 4. 4. SCT lowered PFV in frogs and elevated it in rats. The directions of SCT-induced fluxes in PFV and plasma phosphorus were opposite to each other in both amphibians and the rat. 5. 5. The rapid SCT-induced changes in plasma mineral levels and PFV, which were reversed in the amphibian as compared to the rat, may be the consequence of transcompartmental shifts in ions and water, involving the interplay of bone cells, bone fluid, extracellular fluids, soft tissues and plasma." @default.
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- W2017366933 date "1978-01-01" @default.
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- W2017366933 title "A comparative study of the influence of calcitonin on plasma mineral and volume dynamics in the amphibians, Rana pipiens and Xenopus laevis, and the rat" @default.
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