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• W2017367404 endingPage "738" @default.
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• W2017367404 abstract "Although lower levels of omega-3 polyunsaturated fatty acids (PUFAs) are found in major depressive disorder, less is known about PUFA status and anxiety disorders.Medication-free participants with DSM-IV-defined major depressive disorder (MDD), with (n = 18) and without (n = 41) comorbid DSM-IV anxiety disorders, and healthy volunteers (n = 62) were recruited from October 2006 to May 2010 for mood disorder studies at the New York State Psychiatric Institute. Participants were 18-73 years of age (mean age, 35.8 ± 12.6 years). Depression and anxiety severity was assessed using depression and anxiety subscales from the 17-item Hamilton Depression Rating Scale. Plasma PUFAs eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) and the ratio of arachidonic acid (AA; 22:4n-6) to EPA (AA:EPA) were quantified. This secondary analysis employed analysis of variance with a priori planned contrasts to test for diagnostic group differences in log-transformed PUFA levels (logDHA, logEPA, and logAA:EPA).Plasma levels of logDHA (F(2,118) = 4.923, P = .009), logEPA (F(2,118) = 6.442, P = .002), and logAA:EPA (F(2,118) = 3.806, P = .025) differed across groups. Participants with MDD had lower logDHA (t(118) = 2.324, P = .022) and logEPA (t(118) = 3.175, P = .002) levels and higher logAA:EPA levels (t(118) = -2.099, P = .038) compared with healthy volunteers. Lower logDHA (t(118) = 2.692, P = .008) and logEPA (t(118) = 2.524, P = .013) levels and higher logAA:EPA levels (t(118) = -2.322, P = .022) distinguished anxious from nonanxious MDD. Depression severity was not associated with PUFA plasma levels; however, anxiety severity across the entire sample correlated negatively with logDHA (r(p) = -0.22, P = .015) and logEPA (r(p) = -0.25, P = .005) levels and positively with logAA:EPA levels (r(p) = 0.18, P = .043).The presence and severity of comorbid anxiety were associated with the lowest EPA and DHA levels. Further studies are needed to elucidate whether omega-3 PUFA supplementation may preferentially alleviate MDD with more severe anxiety." @default.
• W2017367404 created "2016-06-24" @default.
• W2017367404 creator A5014967834 @default.
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• W2017367404 date "2013-07-15" @default.
• W2017367404 modified "2023-09-25" @default.
• W2017367404 title "Omega-3 Polyunsaturated Fatty Acid (PUFA) Status in Major Depressive Disorder With Comorbid Anxiety Disorders" @default.
• W2017367404 cites W1579904080 @default.
• W2017367404 cites W1922049770 @default.
• W2017367404 cites W1964889049 @default.
• W2017367404 cites W1966969969 @default.
• W2017367404 cites W1969440422 @default.
• W2017367404 cites W1974514273 @default.
• W2017367404 cites W1976975701 @default.
• W2017367404 cites W1977857319 @default.
• W2017367404 cites W1980568154 @default.
• W2017367404 cites W1980951339 @default.
• W2017367404 cites W1986859888 @default.
• W2017367404 cites W1987061769 @default.
• W2017367404 cites W1991671460 @default.
• W2017367404 cites W1992320423 @default.
• W2017367404 cites W1995947208 @default.
• W2017367404 cites W1996454121 @default.
• W2017367404 cites W1998410787 @default.
• W2017367404 cites W1998457133 @default.
• W2017367404 cites W2001053592 @default.
• W2017367404 cites W2003494755 @default.
• W2017367404 cites W2004754261 @default.
• W2017367404 cites W2004842212 @default.
• W2017367404 cites W2019856631 @default.
• W2017367404 cites W2022352764 @default.
• W2017367404 cites W2022654707 @default.
• W2017367404 cites W2034824946 @default.
• W2017367404 cites W2037577652 @default.
• W2017367404 cites W2039066744 @default.
• W2017367404 cites W2042223411 @default.
• W2017367404 cites W2043652950 @default.
• W2017367404 cites W2045110077 @default.
• W2017367404 cites W2046078045 @default.
• W2017367404 cites W2050066770 @default.
• W2017367404 cites W2051359310 @default.
• W2017367404 cites W2053403355 @default.
• W2017367404 cites W2053612684 @default.
• W2017367404 cites W2058759125 @default.
• W2017367404 cites W2063682731 @default.
• W2017367404 cites W2065916400 @default.
• W2017367404 cites W2066503688 @default.
• W2017367404 cites W2066801193 @default.
• W2017367404 cites W2067495470 @default.
• W2017367404 cites W2069157558 @default.
• W2017367404 cites W2069224827 @default.
• W2017367404 cites W2069369539 @default.
• W2017367404 cites W2074868853 @default.
• W2017367404 cites W2077794554 @default.
• W2017367404 cites W2079816339 @default.
• W2017367404 cites W2084313555 @default.
• W2017367404 cites W2088021051 @default.
• W2017367404 cites W2088629264 @default.
• W2017367404 cites W2089036448 @default.
• W2017367404 cites W2089606257 @default.
• W2017367404 cites W2094437294 @default.
• W2017367404 cites W2102084287 @default.
• W2017367404 cites W2102422901 @default.
• W2017367404 cites W2108479409 @default.
• W2017367404 cites W2109225320 @default.
• W2017367404 cites W2109322748 @default.
• W2017367404 cites W2110264169 @default.
• W2017367404 cites W2112704917 @default.
• W2017367404 cites W2112953965 @default.
• W2017367404 cites W2114613490 @default.
• W2017367404 cites W2117752152 @default.
• W2017367404 cites W2118826874 @default.
• W2017367404 cites W2121371688 @default.
• W2017367404 cites W2122285204 @default.
• W2017367404 cites W2123374151 @default.
• W2017367404 cites W2124566456 @default.
• W2017367404 cites W2125555008 @default.
• W2017367404 cites W2127842994 @default.
• W2017367404 cites W2134859626 @default.
• W2017367404 cites W2137001845 @default.
• W2017367404 cites W2140302561 @default.
• W2017367404 cites W2140409786 @default.
• W2017367404 cites W2140758044 @default.
• W2017367404 cites W2141570342 @default.
• W2017367404 cites W2142693281 @default.
• W2017367404 cites W2153299553 @default.
• W2017367404 cites W2161901125 @default.
• W2017367404 cites W2162066663 @default.
• W2017367404 cites W2163651074 @default.
• W2017367404 cites W2170684975 @default.
• W2017367404 cites W2170701421 @default.
• W2017367404 cites W2171401470 @default.
• W2017367404 cites W2185289178 @default.

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