FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017371391> ?p ?o ?g. }

• W2017371391 endingPage "1111" @default.
• W2017371391 startingPage "1104" @default.
• W2017371391 abstract "Traumatic spinal cord injury (SCI) typically involves intraparenchymal hemorrhage and a cascade of inflammatory and cytotoxic processes leading to tissue necrosis and apoptosis. A consequence of the hemorrhage is the accumulation of deoxygenated heme proximal and distal to the epicenter of the lesion. The heme oxygenase (HO) system is an endogenous heme degradation system and is upregulated following neurotrauma. The breakdown of heme via HO activity yields the byproducts carbon monoxide (CO), biliverdin, and iron. CO has documented neuromodulatory properties; however, the effects of elevated concentrations of CO on axonal conduction in the spinal cord have not previously been studied. The present study tested the hypothesis that CO causes alterations in the electrophysiological properties of axons within the isolated guinea-pig spinal cord. Ex vivo spinal cord preparations were exposed to 100, 500, and 1000 microM concentrations of the carbon monoxide-releasing molecule (CORM) 2 for 30 min in a double sucrose gap electrophysiological recording system and the compound action potential (CAP) and membrane potential (CMP) were recorded continuously during pretreatment, CORM-2 treatment, and washout (30 min) with Krebs' solution. CAP amplitude and area were significantly (P<0.05) reduced following treatment with 500 and 1000 microM CORM-2 and did not recover during washout. No effect on CMP was observed, however, stimulus-peak latency did increase significantly (P<0.05) following CORM-2 treatment at these concentrations, and a decrease in the amplitude of the second CAP elicited by paired-pulse stimulation was also evident at interpulse intervals of 2 and 4 ms. These results are consistent with a CO-induced alteration in axonal conduction, possibly attributable to modified Na+ channel conductance. They also identify a new mechanism by which post-traumatic hemorrhage contributes to the neurological deficits observed following SCI." @default.
• W2017371391 created "2016-06-24" @default.
• W2017371391 creator A5055982196 @default.
• W2017371391 creator A5073733827 @default.
• W2017371391 creator A5089966009 @default.
• W2017371391 date "2008-02-01" @default.
• W2017371391 modified "2023-09-26" @default.
• W2017371391 title "Carbon monoxide–releasing molecule tricarbonyldichlororuthenium (II) dimer induces concentration-dependent alterations in the electrophysiological properties of axons in mammalian spinal cord" @default.
• W2017371391 cites W1484225253 @default.
• W2017371391 cites W1536484729 @default.
• W2017371391 cites W1561810071 @default.
• W2017371391 cites W1753091109 @default.
• W2017371391 cites W1865973687 @default.
• W2017371391 cites W1872514626 @default.
• W2017371391 cites W1964771745 @default.
• W2017371391 cites W1966436656 @default.
• W2017371391 cites W1966444205 @default.
• W2017371391 cites W1970057053 @default.
• W2017371391 cites W1979190686 @default.
• W2017371391 cites W1981165639 @default.
• W2017371391 cites W1982691215 @default.
• W2017371391 cites W1984098569 @default.
• W2017371391 cites W1988073879 @default.
• W2017371391 cites W2003839114 @default.
• W2017371391 cites W2005554057 @default.
• W2017371391 cites W2014963097 @default.
• W2017371391 cites W2019867783 @default.
• W2017371391 cites W2021946435 @default.
• W2017371391 cites W2027539560 @default.
• W2017371391 cites W2028812421 @default.
• W2017371391 cites W2032979266 @default.
• W2017371391 cites W2033083444 @default.
• W2017371391 cites W2040871722 @default.
• W2017371391 cites W2041779622 @default.
• W2017371391 cites W2055127611 @default.
• W2017371391 cites W2071453138 @default.
• W2017371391 cites W2073424392 @default.
• W2017371391 cites W2076925556 @default.
• W2017371391 cites W2081743596 @default.
• W2017371391 cites W2083472765 @default.
• W2017371391 cites W2084195580 @default.
• W2017371391 cites W2102291861 @default.
• W2017371391 cites W2107565079 @default.
• W2017371391 cites W2112107066 @default.
• W2017371391 cites W2117976022 @default.
• W2017371391 cites W2123444403 @default.
• W2017371391 cites W2149546308 @default.
• W2017371391 cites W2149821716 @default.
• W2017371391 cites W2161544100 @default.
• W2017371391 cites W2165989556 @default.
• W2017371391 cites W2170942810 @default.
• W2017371391 cites W2187974257 @default.
• W2017371391 cites W2316695087 @default.
• W2017371391 cites W2093838689 @default.
• W2017371391 doi "https://doi.org/10.1016/j.neuroscience.2007.12.002" @default.
• W2017371391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18248914" @default.
• W2017371391 hasPublicationYear "2008" @default.
• W2017371391 type Work @default.
• W2017371391 sameAs 2017371391 @default.
• W2017371391 citedByCount "10" @default.
• W2017371391 countsByYear W20173713912013 @default.
• W2017371391 countsByYear W20173713912017 @default.
• W2017371391 countsByYear W20173713912021 @default.
• W2017371391 crossrefType "journal-article" @default.
• W2017371391 hasAuthorship W2017371391A5055982196 @default.
• W2017371391 hasAuthorship W2017371391A5073733827 @default.
• W2017371391 hasAuthorship W2017371391A5089966009 @default.
• W2017371391 hasConcept C12554922 @default.
• W2017371391 hasConcept C126322002 @default.
• W2017371391 hasConcept C169760540 @default.
• W2017371391 hasConcept C181199279 @default.
• W2017371391 hasConcept C185263204 @default.
• W2017371391 hasConcept C185592680 @default.
• W2017371391 hasConcept C2776217839 @default.
• W2017371391 hasConcept C2776253728 @default.
• W2017371391 hasConcept C2779219270 @default.
• W2017371391 hasConcept C2780358027 @default.
• W2017371391 hasConcept C2780775167 @default.
• W2017371391 hasConcept C42219234 @default.
• W2017371391 hasConcept C55493867 @default.
• W2017371391 hasConcept C71924100 @default.
• W2017371391 hasConcept C86803240 @default.
• W2017371391 hasConceptScore W2017371391C12554922 @default.
• W2017371391 hasConceptScore W2017371391C126322002 @default.
• W2017371391 hasConceptScore W2017371391C169760540 @default.
• W2017371391 hasConceptScore W2017371391C181199279 @default.
• W2017371391 hasConceptScore W2017371391C185263204 @default.
• W2017371391 hasConceptScore W2017371391C185592680 @default.
• W2017371391 hasConceptScore W2017371391C2776217839 @default.
• W2017371391 hasConceptScore W2017371391C2776253728 @default.
• W2017371391 hasConceptScore W2017371391C2779219270 @default.
• W2017371391 hasConceptScore W2017371391C2780358027 @default.
• W2017371391 hasConceptScore W2017371391C2780775167 @default.
• W2017371391 hasConceptScore W2017371391C42219234 @default.
• W2017371391 hasConceptScore W2017371391C55493867 @default.
• W2017371391 hasConceptScore W2017371391C71924100 @default.
• W2017371391 hasConceptScore W2017371391C86803240 @default.
• W2017371391 hasIssue "4" @default.

• next