FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017372213> ?p ?o ?g. }

• W2017372213 endingPage "7369" @default.
• W2017372213 startingPage "7356" @default.
• W2017372213 abstract "In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion bypass. Although the majority of reported data support a model whereby monoubiquitinated PCNA enhances its affinity for TLS polymerases and hence recruits them to the damage sites, this model has also been challenged by several observations. In this study, we expressed the PCNA-164R and ubiquitin (UB) fusion genes in an inducible manner in an attempt to mimic PCNA monoubiquitination in cultured human cells. It was found that expression of both N- and C-terminal PCNA•Ub fusions conferred significant tolerance to ultraviolet (UV)-induced DNA damage. Surprisingly, depletion of Polη, a TLS polymerase dedicated to bypassing UV-induced pyrimidine dimers, did not alter tolerance conferred by PCNA•Ub. In contrast, depletion of Rev1, another TLS polymerase serving as a scaffold for the assembly of the TLS complex, completely abolished PCNA•Ub-mediated damage tolerance. Similar genetic interactions were confirmed when UV-induced monoubiquitination of endogenous PCNA is abolished by RAD18 deletion. Hence, PCNA•Ub fusions bypass the requirement for PCNA monoubiquitination, and UV damage tolerance conferred by these fusions is dependent on Rev1 but independent of Polη." @default.
• W2017372213 created "2016-06-24" @default.
• W2017372213 creator A5019308473 @default.
• W2017372213 creator A5025881097 @default.
• W2017372213 creator A5030898402 @default.
• W2017372213 creator A5034134761 @default.
• W2017372213 creator A5048652457 @default.
• W2017372213 creator A5052203784 @default.
• W2017372213 date "2013-06-12" @default.
• W2017372213 modified "2023-09-27" @default.
• W2017372213 title "DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη" @default.
• W2017372213 cites W1507151273 @default.
• W2017372213 cites W1537782690 @default.
• W2017372213 cites W1840855988 @default.
• W2017372213 cites W1944130357 @default.
• W2017372213 cites W1965011585 @default.
• W2017372213 cites W1970925815 @default.
• W2017372213 cites W1979000046 @default.
• W2017372213 cites W1979095965 @default.
• W2017372213 cites W1982782744 @default.
• W2017372213 cites W1982897179 @default.
• W2017372213 cites W1985746590 @default.
• W2017372213 cites W1986065576 @default.
• W2017372213 cites W1995038234 @default.
• W2017372213 cites W1996368299 @default.
• W2017372213 cites W1996462501 @default.
• W2017372213 cites W1997803780 @default.
• W2017372213 cites W1998604023 @default.
• W2017372213 cites W2001209925 @default.
• W2017372213 cites W2019594784 @default.
• W2017372213 cites W2020136215 @default.
• W2017372213 cites W2020866179 @default.
• W2017372213 cites W2024388814 @default.
• W2017372213 cites W2024703739 @default.
• W2017372213 cites W2026768632 @default.
• W2017372213 cites W2029287748 @default.
• W2017372213 cites W2032124996 @default.
• W2017372213 cites W2032706602 @default.
• W2017372213 cites W2037909746 @default.
• W2017372213 cites W2046732630 @default.
• W2017372213 cites W2053362861 @default.
• W2017372213 cites W2055400238 @default.
• W2017372213 cites W2057218806 @default.
• W2017372213 cites W2062284662 @default.
• W2017372213 cites W2063079466 @default.
• W2017372213 cites W2063102260 @default.
• W2017372213 cites W2067706093 @default.
• W2017372213 cites W2067786302 @default.
• W2017372213 cites W2067829451 @default.
• W2017372213 cites W2070184285 @default.
• W2017372213 cites W2072747624 @default.
• W2017372213 cites W2072969527 @default.
• W2017372213 cites W2077602225 @default.
• W2017372213 cites W2079691419 @default.
• W2017372213 cites W2088339455 @default.
• W2017372213 cites W2098418459 @default.
• W2017372213 cites W2099367992 @default.
• W2017372213 cites W2105513499 @default.
• W2017372213 cites W2107935862 @default.
• W2017372213 cites W2109247109 @default.
• W2017372213 cites W2111202021 @default.
• W2017372213 cites W2111616806 @default.
• W2017372213 cites W2118265560 @default.
• W2017372213 cites W2119301405 @default.
• W2017372213 cites W2121781216 @default.
• W2017372213 cites W2122748184 @default.
• W2017372213 cites W2123985521 @default.
• W2017372213 cites W2126493139 @default.
• W2017372213 cites W2130381855 @default.
• W2017372213 cites W2131510695 @default.
• W2017372213 cites W2135858046 @default.
• W2017372213 cites W2138261613 @default.
• W2017372213 cites W2143064529 @default.
• W2017372213 cites W2154462755 @default.
• W2017372213 cites W2156419287 @default.
• W2017372213 cites W2160330189 @default.
• W2017372213 cites W2162276082 @default.
• W2017372213 cites W2163464064 @default.
• W2017372213 cites W2163976338 @default.
• W2017372213 cites W2167668429 @default.
• W2017372213 cites W2169534711 @default.
• W2017372213 cites W2169950973 @default.
• W2017372213 cites W2281048538 @default.
• W2017372213 doi "https://doi.org/10.1093/nar/gkt542" @default.
• W2017372213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3753651" @default.
• W2017372213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23761444" @default.
• W2017372213 hasPublicationYear "2013" @default.
• W2017372213 type Work @default.
• W2017372213 sameAs 2017372213 @default.
• W2017372213 citedByCount "24" @default.
• W2017372213 countsByYear W20173722132015 @default.
• W2017372213 countsByYear W20173722132016 @default.
• W2017372213 countsByYear W20173722132017 @default.
• W2017372213 countsByYear W20173722132018 @default.
• W2017372213 countsByYear W20173722132019 @default.
• W2017372213 countsByYear W20173722132020 @default.
• W2017372213 countsByYear W20173722132021 @default.
• W2017372213 countsByYear W20173722132022 @default.

• next