FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017372938> ?p ?o ?g. }

• W2017372938 endingPage "210" @default.
• W2017372938 startingPage "199" @default.
• W2017372938 abstract "The cytotoxic activity of killer (K) cells against enriched cultures of bovine oligodendrocytes (BOL) was investigated in multiple sclerosis (MS) and controls. Human K cells mediated cytotoxicity to primary cultures of BOL in the presence of anti-BOL antiserum in all study groups, while BOL were resistant to human natural killer (NK) cells. Cytotoxic activity was significantly reduced in MS when compared to age-matched normal controls but not when compared to other neurologic disease (OND) patients. K cell-mediated lysis of BOL could also be induced with anti-galactocerebroside antibody but not with other antibodies including those specific for OL antigens (myelin basic protein, proteolipid apoprotein, and 2',3'-cyclic nucleotide 3'-phosphodiesterase). Enrichment of the effector population indicated that antibody-dependent cell-mediated cytotoxicity (ADCC) to BOL was mediated by large granular lymphocytes, and the effector population was further characterized by flow cytometry. The effector cells mediating ADCC could be inhibited by protein A of Staphylococcus aureus, and by K562 cells in cold competition assay. These observations indicate that oligodendrocytes are resistant to NK cells but are susceptible to cytolysis mediated by K cells. This may represent a potentially important immune mechanism in the pathogenesis of MS." @default.
• W2017372938 created "2016-06-24" @default.
• W2017372938 creator A5003703784 @default.
• W2017372938 creator A5024460308 @default.
• W2017372938 creator A5040109906 @default.
• W2017372938 date "1991-03-01" @default.
• W2017372938 modified "2023-09-26" @default.
• W2017372938 title "Cytolysis of oligodendrocytes is mediated by killer (K) cells but not by natural killer (NK) cells" @default.
• W2017372938 cites W1489274209 @default.
• W2017372938 cites W1551700830 @default.
• W2017372938 cites W1556867369 @default.
• W2017372938 cites W168029340 @default.
• W2017372938 cites W1966734628 @default.
• W2017372938 cites W1968634466 @default.
• W2017372938 cites W1971353171 @default.
• W2017372938 cites W1992999698 @default.
• W2017372938 cites W1997952261 @default.
• W2017372938 cites W1998398900 @default.
• W2017372938 cites W2000165564 @default.
• W2017372938 cites W2003933970 @default.
• W2017372938 cites W2015064054 @default.
• W2017372938 cites W2020944851 @default.
• W2017372938 cites W2022614609 @default.
• W2017372938 cites W2023059564 @default.
• W2017372938 cites W2025392129 @default.
• W2017372938 cites W2031646442 @default.
• W2017372938 cites W2053572501 @default.
• W2017372938 cites W2056835990 @default.
• W2017372938 cites W2057715076 @default.
• W2017372938 cites W2060944813 @default.
• W2017372938 cites W2066982884 @default.
• W2017372938 cites W2075536972 @default.
• W2017372938 cites W2078326745 @default.
• W2017372938 cites W2080595384 @default.
• W2017372938 cites W2085516673 @default.
• W2017372938 cites W2086026420 @default.
• W2017372938 cites W2087349900 @default.
• W2017372938 cites W2089567287 @default.
• W2017372938 cites W2112165124 @default.
• W2017372938 cites W2155399115 @default.
• W2017372938 cites W2161082695 @default.
• W2017372938 cites W2163296540 @default.
• W2017372938 cites W2177985207 @default.
• W2017372938 cites W2413141528 @default.
• W2017372938 cites W2413496808 @default.
• W2017372938 cites W2466934396 @default.
• W2017372938 doi "https://doi.org/10.1016/0165-5728(91)90041-5" @default.
• W2017372938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1995651" @default.
• W2017372938 hasPublicationYear "1991" @default.
• W2017372938 type Work @default.
• W2017372938 sameAs 2017372938 @default.
• W2017372938 citedByCount "7" @default.
• W2017372938 countsByYear W20173729382021 @default.
• W2017372938 crossrefType "journal-article" @default.
• W2017372938 hasAuthorship W2017372938A5003703784 @default.
• W2017372938 hasAuthorship W2017372938A5024460308 @default.
• W2017372938 hasAuthorship W2017372938A5040109906 @default.
• W2017372938 hasConcept C109316439 @default.
• W2017372938 hasConcept C129374314 @default.
• W2017372938 hasConcept C147483822 @default.
• W2017372938 hasConcept C153911025 @default.
• W2017372938 hasConcept C154317977 @default.
• W2017372938 hasConcept C159654299 @default.
• W2017372938 hasConcept C171122931 @default.
• W2017372938 hasConcept C202751555 @default.
• W2017372938 hasConcept C203014093 @default.
• W2017372938 hasConcept C206191192 @default.
• W2017372938 hasConcept C2776090121 @default.
• W2017372938 hasConcept C2778102761 @default.
• W2017372938 hasConcept C2778461978 @default.
• W2017372938 hasConcept C28651165 @default.
• W2017372938 hasConcept C2908647359 @default.
• W2017372938 hasConcept C40677261 @default.
• W2017372938 hasConcept C542903549 @default.
• W2017372938 hasConcept C55493867 @default.
• W2017372938 hasConcept C71924100 @default.
• W2017372938 hasConcept C73588182 @default.
• W2017372938 hasConcept C86803240 @default.
• W2017372938 hasConcept C8891405 @default.
• W2017372938 hasConcept C99454951 @default.
• W2017372938 hasConceptScore W2017372938C109316439 @default.
• W2017372938 hasConceptScore W2017372938C129374314 @default.
• W2017372938 hasConceptScore W2017372938C147483822 @default.
• W2017372938 hasConceptScore W2017372938C153911025 @default.
• W2017372938 hasConceptScore W2017372938C154317977 @default.
• W2017372938 hasConceptScore W2017372938C159654299 @default.
• W2017372938 hasConceptScore W2017372938C171122931 @default.
• W2017372938 hasConceptScore W2017372938C202751555 @default.
• W2017372938 hasConceptScore W2017372938C203014093 @default.
• W2017372938 hasConceptScore W2017372938C206191192 @default.
• W2017372938 hasConceptScore W2017372938C2776090121 @default.
• W2017372938 hasConceptScore W2017372938C2778102761 @default.
• W2017372938 hasConceptScore W2017372938C2778461978 @default.
• W2017372938 hasConceptScore W2017372938C28651165 @default.
• W2017372938 hasConceptScore W2017372938C2908647359 @default.
• W2017372938 hasConceptScore W2017372938C40677261 @default.
• W2017372938 hasConceptScore W2017372938C542903549 @default.
• W2017372938 hasConceptScore W2017372938C55493867 @default.

• next