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- W2017374678 abstract "In order to scrutinize the adherence-dependent interactions for induction of granulocyte colony-stimulating factor (G-CSF) in peripheral monocytes/macrophages, a sensitive reporter gene assay was constructed using the mouse macrophage cell line transfected with the mouse G-CSF promoter region in conjunction with the luciferase gene as a reporter. With this system, lipopolysaccharide (LPS) showed a markedly positive response. Among the extracellular matrix (ECM) proteins, both fibronectin (FN) and vitronectin (VN) markedly induced luciferase activity, but others did so to a much lesser extent. Among the synthetic peptides having Arg-Gly-Asp (RGD) sequences, only FLEPP with multiple RGD significantly induced luciferase activity. Pretreatment of the cells with anti-integrin α6, αM, β1 and β2 monoclonal antibodies (mAbs) significantly reduced the LPS-induced responses and anti-α1, α2 and β3 mAbs to a lesser extent, and anti-α5, α6, αM, β1 and β2 mAbs blocked the FN-induced response. In the cell-to-cell interactions, a significantly positive increase was observed by direct contacting of this cell line with a G-CSF-dependent promyelocytic leukaemia cell line, known to stimulate the induction of G-CSF to the stromal cells. Its effect was mostly blocked by pretreatment with anti-intergrin α5, αL, β1 and β2 and anti-ICAM-1 mAbs. These results indicate that there are several pathways via the cell-to-ECM and cell-to-cell interactions triggering the induction of G-CSF in the macrophages." @default.
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- W2017374678 date "1998-08-01" @default.
- W2017374678 modified "2023-10-06" @default.
- W2017374678 title "STIMULATION OF G-CSF GENE EXPRESSION IN THE MACROPHAGE CELL LINE BY CONTACT WITH EXTRACELLULAR MATRIX PROTEINS AND A PRE-B LEUKAEMIA CELL LINE" @default.
- W2017374678 doi "https://doi.org/10.1006/cyto.1997.0338" @default.
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