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• W2017375629 abstract "Acute esophagitis is one of the most common side effects among lung cancer patients treated with high-dose radiotherapy (RT) or radiotherapy combined with chemotherapy (CRT). The objective evaluation of patients with such treatment-induced esophagitis remains a challenge to clinicians, since the diagnosis and management are based largely on patients' symptoms and their clinical history. In this study, we explored the utility of restaging FDG-PET as an objective means to identify treatment-induced esophagitis. FDG-PET scans were performed prior to, 10-14 days and 3 months after the completion of RT or CRT as a part of on-going Partners Protocol 03-282. These scans were analyzed (1) qualitatively by trained observers using a visual score system and (2) quantitatively using the Standard Uptake Value (SUV) method corrected for weight. Detailed patient reports including full clinical history and self-reported surveys on their graded esophageal symptom scales from 0 to 10 were reviewed. Subsequently, the patients with esophageal symptoms were grouped according to the Common Terminology Criteria for Adverse Events (CTCAE). Of the 89 lung cancer patients entered into the study, 43 patients (48%) reported esophageal symptoms. Of these 43, 40 patients showed increased FDG uptake 10-14 days after the completion of RT or CRT, and only 15 patients showed persistent uptake at 3 months post RT or CRT. Patients with grade 1 esophagitis (n = 22) had an average SUV of 2.53; grade 2 (n = 10) 2.89; grade 3 (n = 11) 2.70. Patients with no esophagitis (n = 46) had an average SUV of 1.81. Correlation coefficients (R) between qualitative visual scores vs. SUVs, CTCAE grades, and survey pain scores were 0.77, 0.67, and 0.57 respectively. Restaging FDG-PET performed 10-14 days after the completion of RT or CRT for tumor response could be an objective way to identify treatment-induced esophagitis. Poor correlation was noted between survey pain scores and qualitative visual scores of FDG-PET. Quantitative analysis of FDG-PET may provide additional information on the location and severity of esophagitis that would be useful for its clinical management." @default.
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• W2017375629 date "2008-09-01" @default.
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• W2017375629 title "Esophagitis Identified in Restaging FDG-PET after Radiotherapy or Chemo-radiotherapy in Lung Cancer" @default.
• W2017375629 doi "https://doi.org/10.1016/j.ijrobp.2008.06.1842" @default.
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