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- W2017376095 abstract "Introduction During gestation diminished maternal insulin sensitivity (IS) increases the availability of fuels allowing fetal growth. Class III obesity (OB; BMI≥40kg/m2) is associated with reduced IS but it is not known how nutrient availability differs and how this impacts on birth-weight versus normal pregnancies (CON). Methods 213 OB (median(interquartile range) 43.2(41.1-46.3)kg/m2) and 87 CON (BMI 22.6(21.2-23.5)kg/m2) pregnant Caucasians had maternal anthropometrics, fasting glucose, NEFA and insulin concentrations recorded at 16, 28 and 36 weeks(wk). Premature births (4 OB, 1 CON) were excluded. Results Weight gain (WG) was greater in CON vs. OB (10.4(7.6-13.0)kg vs. 5.2(2.4-8.3)kg; p Conclusion OB women were more insulin resistant vs. CON during pregnancy, with greater glucose, NEFA and insulin concentrations and greater adjusted birth-weights. Glucose was associated with birth weight in the OB and NEFA in the CON which may indicate altered fetal preference for metabolites during these pregnancies." @default.
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- W2017376095 date "2012-04-01" @default.
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- W2017376095 title "Clinical and metabolic profiles of very severely obese pregnant women and their associations with birth weight" @default.
- W2017376095 doi "https://doi.org/10.1136/fetalneonatal-2012-301809.128" @default.
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