FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017376535> ?p ?o ?g. }

• W2017376535 endingPage "18" @default.
• W2017376535 startingPage "13" @default.
• W2017376535 abstract "In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the protective effect of KR466 is mediated through mitochondrial ATP-sensitive potassium (mtK(ATP)) opening. The treatment of H9c2 cells with KR466 (3 - 30 microM) significantly reduced hypoxia-induced cell death in a concentration-dependent manner, as shown by lactate dehydrogenase release and propidium iodide-uptake. In addition, KR466 (10 microM) significantly reduced the increase in hypoxia-induced TUNEL-positive cells, suggesting its anti-apoptotic potential in H9c2 cells. The protective effects of KR466 were abolished by 5-hydroxydecanoate, a specific blocker of the mtK(ATP) channel, suggesting the involvement of the mtK(ATP) channel in the protective effect of KR466. A specific inhibitor of protein kinase C (PKC), chelerythrine (3 microM), significantly attenuated the protective effect of KR466 against hypoxia-induced cardiac cell death. In conclusion, our results suggest that KR466 can protect H9c2 cells from hypoxia-induced death through mtK(ATP) channel opening and PKC activation." @default.
• W2017376535 created "2016-06-24" @default.
• W2017376535 creator A5001217563 @default.
• W2017376535 creator A5016365613 @default.
• W2017376535 creator A5018035381 @default.
• W2017376535 creator A5043240094 @default.
• W2017376535 creator A5043855440 @default.
• W2017376535 creator A5045334638 @default.
• W2017376535 creator A5051301807 @default.
• W2017376535 creator A5052669348 @default.
• W2017376535 creator A5065804959 @default.
• W2017376535 creator A5068039063 @default.
• W2017376535 creator A5070434251 @default.
• W2017376535 date "2003-01-01" @default.
• W2017376535 modified "2023-10-18" @default.
• W2017376535 title "KR-31466, a Benzopyranylindol Analog, Attenuates Hypoxic Injury Through Mitochondrial KATP Channel and Protein Kinase C Activation in Heart-Derived H9c2 Cells" @default.
• W2017376535 cites W1854633548 @default.
• W2017376535 cites W1963886220 @default.
• W2017376535 cites W1972272884 @default.
• W2017376535 cites W1980307873 @default.
• W2017376535 cites W1981182006 @default.
• W2017376535 cites W1987420883 @default.
• W2017376535 cites W1995327987 @default.
• W2017376535 cites W2007939778 @default.
• W2017376535 cites W2015687432 @default.
• W2017376535 cites W2023494473 @default.
• W2017376535 cites W2027310465 @default.
• W2017376535 cites W2029177634 @default.
• W2017376535 cites W2048324451 @default.
• W2017376535 cites W2054474511 @default.
• W2017376535 cites W2057824614 @default.
• W2017376535 cites W2069537903 @default.
• W2017376535 cites W2074301028 @default.
• W2017376535 cites W2088629114 @default.
• W2017376535 cites W2100405364 @default.
• W2017376535 cites W2121962823 @default.
• W2017376535 cites W2126241200 @default.
• W2017376535 cites W2129167542 @default.
• W2017376535 cites W2136545895 @default.
• W2017376535 cites W2146217294 @default.
• W2017376535 cites W2151126528 @default.
• W2017376535 cites W2153475498 @default.
• W2017376535 doi "https://doi.org/10.1254/jphs.92.13" @default.
• W2017376535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12832850" @default.
• W2017376535 hasPublicationYear "2003" @default.
• W2017376535 type Work @default.
• W2017376535 sameAs 2017376535 @default.
• W2017376535 citedByCount "6" @default.
• W2017376535 countsByYear W20173765352014 @default.
• W2017376535 crossrefType "journal-article" @default.
• W2017376535 hasAuthorship W2017376535A5001217563 @default.
• W2017376535 hasAuthorship W2017376535A5016365613 @default.
• W2017376535 hasAuthorship W2017376535A5018035381 @default.
• W2017376535 hasAuthorship W2017376535A5043240094 @default.
• W2017376535 hasAuthorship W2017376535A5043855440 @default.
• W2017376535 hasAuthorship W2017376535A5045334638 @default.
• W2017376535 hasAuthorship W2017376535A5051301807 @default.
• W2017376535 hasAuthorship W2017376535A5052669348 @default.
• W2017376535 hasAuthorship W2017376535A5065804959 @default.
• W2017376535 hasAuthorship W2017376535A5068039063 @default.
• W2017376535 hasAuthorship W2017376535A5070434251 @default.
• W2017376535 hasBestOaLocation W20173765351 @default.
• W2017376535 hasConcept C134018914 @default.
• W2017376535 hasConcept C178790620 @default.
• W2017376535 hasConcept C181199279 @default.
• W2017376535 hasConcept C184235292 @default.
• W2017376535 hasConcept C185592680 @default.
• W2017376535 hasConcept C190283241 @default.
• W2017376535 hasConcept C195794163 @default.
• W2017376535 hasConcept C2775934118 @default.
• W2017376535 hasConcept C2776108454 @default.
• W2017376535 hasConcept C2776309818 @default.
• W2017376535 hasConcept C2777318727 @default.
• W2017376535 hasConcept C2779768347 @default.
• W2017376535 hasConcept C28859421 @default.
• W2017376535 hasConcept C31573885 @default.
• W2017376535 hasConcept C540031477 @default.
• W2017376535 hasConcept C55493867 @default.
• W2017376535 hasConcept C555293320 @default.
• W2017376535 hasConcept C71924100 @default.
• W2017376535 hasConcept C7836513 @default.
• W2017376535 hasConcept C83743174 @default.
• W2017376535 hasConcept C97029542 @default.
• W2017376535 hasConcept C98274493 @default.
• W2017376535 hasConceptScore W2017376535C134018914 @default.
• W2017376535 hasConceptScore W2017376535C178790620 @default.
• W2017376535 hasConceptScore W2017376535C181199279 @default.
• W2017376535 hasConceptScore W2017376535C184235292 @default.
• W2017376535 hasConceptScore W2017376535C185592680 @default.
• W2017376535 hasConceptScore W2017376535C190283241 @default.
• W2017376535 hasConceptScore W2017376535C195794163 @default.
• W2017376535 hasConceptScore W2017376535C2775934118 @default.
• W2017376535 hasConceptScore W2017376535C2776108454 @default.
• W2017376535 hasConceptScore W2017376535C2776309818 @default.
• W2017376535 hasConceptScore W2017376535C2777318727 @default.
• W2017376535 hasConceptScore W2017376535C2779768347 @default.
• W2017376535 hasConceptScore W2017376535C28859421 @default.
• W2017376535 hasConceptScore W2017376535C31573885 @default.

• next