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• W2017380208 abstract "The first synthetic route of novel 2′(β),3′(β)-C-dimethyl carbodine analogues is described. The key intermediate cyclopentenyl alcohol 11(β) prepared from Weinreb amide 4 via ring-closing metathesis (RCM) and vicinal dihydroxylation. Coupling of 12 with nucleosidic bases via the Pd(0) catalyzed reaction followed by stereoselective dihydoxylation and deprotection afforded the target carbocyclic nucleoside analogues. The synthesized compounds were evaluated as inhibitors of the hepatitis C virus (HCV) in Huh-7 cell line in vitro. However, the nucleosides failed to inhibit HCV RNA replication in the cell-based replicon assay (EC50 > μM)." @default.
• W2017380208 created "2016-06-24" @default.
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• W2017380208 date "2009-08-27" @default.
• W2017380208 modified "2023-10-09" @default.
• W2017380208 title "Synthesis and In Vitro Activity Evaluation of 2′,3′-<i>C</i>-Dimethyl Carbocyclic Nucleoside Analogues as Potential Anti-HCV Agents" @default.
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• W2017380208 doi "https://doi.org/10.1080/15257770903155642" @default.
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