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- W2017381092 abstract "Initial reports of the interaction between quinidine and digoxin have led to attempts to delineate the various facets of this interaction, forced a reexamination of our understanding of the pharmacodynamics of digitalis glycosides, helped identify related interactions, and provided additional questions for further research. The following considerations delineate the existing data on numerous aspects of the quinidine-digoxin interaction, outline related drug interactions, and identify questions deserving further study. The interaction between quinidine and digoxin, which was first described in 1978, produces a sustained elevation in the serum digoxin concentration (SDC). Since the interaction was first identified several investigators have attempted to define the interaction in terms of its frequency of occurrence, magnitude, time course, and the importance of drug dose or serum level; describe the mechanisms involved; evaluate the clinical significance; and suggest management options." @default.
- W2017381092 created "2016-06-24" @default.
- W2017381092 creator A5057316883 @default.
- W2017381092 date "1982-08-01" @default.
- W2017381092 modified "2023-09-26" @default.
- W2017381092 title "The influence of quinidine and other agents on digitalis glycosides" @default.
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- W2017381092 doi "https://doi.org/10.1016/0002-8703(82)90205-8" @default.
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