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- W2017383257 abstract "In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v administration of drugs and subsequent observation of the percentage of vomiting animals and number of emetic episodes per vomiting animal over a period of 5 h. In some experiments, the 5-HT and 5-HIAA content in tissues was estimated by the HPLC technique. It was observed that cisplatin (2.5–10 mg/kg) is able to induce dose-dependent emesis in the pigeon. 5-HT3 receptor antagonists (500 mg/kg) afford partial protection against cisplatin emesis, although some of them i.e. indolic derivatives and zacopride, display intrinsic emetic activity at doses of 50–500 μg/kg. A serotonergic mechanism appears to be involved in both cisplatin- and 5-HT3 receptor antagonist-induced emesis, since pretreatment with an inhibitor of 5-HT synthesis, para-chlorophenylalanine (300 mg/kg × 3 days), is able to hamper vomiting induced by either cisplatin or 5-HT3 receptor antagonists. It is concluded that the intrinsic emetic effects of 5-HT3 receptor antagonists in the pigeon provide pharmacological evidence of species differences in the properties of 5 HT3 receptors." @default.
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- W2017383257 date "1992-12-01" @default.
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- W2017383257 title "A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon" @default.
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- W2017383257 doi "https://doi.org/10.1016/0378-4274(92)90256-j" @default.
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