FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017383331> ?p ?o ?g. }

• W2017383331 endingPage "13729" @default.
• W2017383331 startingPage "13720" @default.
• W2017383331 abstract "Ca(2+) signaling plays important roles during both axonal and dendritic growth. Yet whether and how Ca(2+) rises may trigger and contribute to the development of long-range cortical connections remains mostly unknown. Here, we demonstrate that two separate limbs of the Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK)-CaMKI cascades, CaMKK-CaMKIalpha and CaMKK-CaMKIgamma, critically coordinate axonal and dendritic morphogenesis of cortical neurons, respectively. The axon-specific morphological phenotype required a diffuse cytoplasmic localization and a strikingly alpha-isoform-specific kinase activity of CaMKI. Unexpectedly, treatment with muscimol, a GABA(A) receptor agonist, selectively stimulated elongation of axons but not of dendrites, and the CaMKK-CaMKIalpha cascade critically mediated this axonogenic effect. Consistent with these findings, during early brain development, in vivo knockdown of CaMKIalpha significantly impaired the terminal axonal extension and thereby perturbed the refinement of the interhemispheric callosal projections into the contralateral cortices. Our findings thus indicate a novel role for the GABA-driven CaMKK-CaMKIalpha cascade as a mechanism critical for accurate cortical axon pathfinding, an essential process that may contribute to fine-tuning the formation of interhemispheric connectivity during the perinatal development of the CNS." @default.
• W2017383331 created "2016-06-24" @default.
• W2017383331 creator A5003603837 @default.
• W2017383331 creator A5004551224 @default.
• W2017383331 creator A5011706591 @default.
• W2017383331 creator A5015084471 @default.
• W2017383331 creator A5025241935 @default.
• W2017383331 creator A5027637898 @default.
• W2017383331 creator A5027699721 @default.
• W2017383331 creator A5032421118 @default.
• W2017383331 creator A5036712866 @default.
• W2017383331 creator A5036715533 @default.
• W2017383331 creator A5047951532 @default.
• W2017383331 creator A5053372897 @default.
• W2017383331 creator A5058080620 @default.
• W2017383331 creator A5067530544 @default.
• W2017383331 creator A5074508362 @default.
• W2017383331 date "2009-10-28" @default.
• W2017383331 modified "2023-10-12" @default.
• W2017383331 title "Control of Cortical Axon Elongation by a GABA-Driven Ca2+/Calmodulin-Dependent Protein Kinase Cascade" @default.
• W2017383331 cites W1548031915 @default.
• W2017383331 cites W1588629441 @default.
• W2017383331 cites W1608349175 @default.
• W2017383331 cites W1705218924 @default.
• W2017383331 cites W1969477930 @default.
• W2017383331 cites W1971851666 @default.
• W2017383331 cites W1976054166 @default.
• W2017383331 cites W1976561247 @default.
• W2017383331 cites W1998977808 @default.
• W2017383331 cites W1999724177 @default.
• W2017383331 cites W2000500986 @default.
• W2017383331 cites W2012476009 @default.
• W2017383331 cites W2017791457 @default.
• W2017383331 cites W2023870062 @default.
• W2017383331 cites W2024398910 @default.
• W2017383331 cites W2024642025 @default.
• W2017383331 cites W2028924647 @default.
• W2017383331 cites W2033712349 @default.
• W2017383331 cites W2035750828 @default.
• W2017383331 cites W2049134173 @default.
• W2017383331 cites W2076195597 @default.
• W2017383331 cites W2078981560 @default.
• W2017383331 cites W2079193109 @default.
• W2017383331 cites W2079297740 @default.
• W2017383331 cites W2080586470 @default.
• W2017383331 cites W2099070047 @default.
• W2017383331 cites W2103802238 @default.
• W2017383331 cites W2106820442 @default.
• W2017383331 cites W2110722854 @default.
• W2017383331 cites W2117329255 @default.
• W2017383331 cites W2118444707 @default.
• W2017383331 cites W2118873240 @default.
• W2017383331 cites W2124248841 @default.
• W2017383331 cites W2125118099 @default.
• W2017383331 cites W2125431234 @default.
• W2017383331 cites W2132369117 @default.
• W2017383331 cites W2135435398 @default.
• W2017383331 cites W2140599912 @default.
• W2017383331 cites W2146605352 @default.
• W2017383331 cites W2165104370 @default.
• W2017383331 cites W2171491435 @default.
• W2017383331 cites W254452930 @default.
• W2017383331 cites W2610226512 @default.
• W2017383331 doi "https://doi.org/10.1523/jneurosci.3018-09.2009" @default.
• W2017383331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2796271" @default.
• W2017383331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19864584" @default.
• W2017383331 hasPublicationYear "2009" @default.
• W2017383331 type Work @default.
• W2017383331 sameAs 2017383331 @default.
• W2017383331 citedByCount "82" @default.
• W2017383331 countsByYear W20173833312012 @default.
• W2017383331 countsByYear W20173833312013 @default.
• W2017383331 countsByYear W20173833312014 @default.
• W2017383331 countsByYear W20173833312015 @default.
• W2017383331 countsByYear W20173833312016 @default.
• W2017383331 countsByYear W20173833312017 @default.
• W2017383331 countsByYear W20173833312018 @default.
• W2017383331 countsByYear W20173833312019 @default.
• W2017383331 countsByYear W20173833312020 @default.
• W2017383331 countsByYear W20173833312021 @default.
• W2017383331 countsByYear W20173833312022 @default.
• W2017383331 countsByYear W20173833312023 @default.
• W2017383331 crossrefType "journal-article" @default.
• W2017383331 hasAuthorship W2017383331A5003603837 @default.
• W2017383331 hasAuthorship W2017383331A5004551224 @default.
• W2017383331 hasAuthorship W2017383331A5011706591 @default.
• W2017383331 hasAuthorship W2017383331A5015084471 @default.
• W2017383331 hasAuthorship W2017383331A5025241935 @default.
• W2017383331 hasAuthorship W2017383331A5027637898 @default.
• W2017383331 hasAuthorship W2017383331A5027699721 @default.
• W2017383331 hasAuthorship W2017383331A5032421118 @default.
• W2017383331 hasAuthorship W2017383331A5036712866 @default.
• W2017383331 hasAuthorship W2017383331A5036715533 @default.
• W2017383331 hasAuthorship W2017383331A5047951532 @default.
• W2017383331 hasAuthorship W2017383331A5053372897 @default.
• W2017383331 hasAuthorship W2017383331A5058080620 @default.
• W2017383331 hasAuthorship W2017383331A5067530544 @default.
• W2017383331 hasAuthorship W2017383331A5074508362 @default.

• next