FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017384512> ?p ?o ?g. }

• W2017384512 endingPage "1751" @default.
• W2017384512 startingPage "1747" @default.
• W2017384512 abstract "IgA deficiency (IgAD) is the most common primary antibody deficiency. Although two-third of the cases are reported to be asymptomatic, some IgAD children may have frequent infections that urge the clinicians to search for prophylactic measures. OM-85 BV is one of these agents that is known to stimulate mucosa associated lymphoid tissue, and upregulate Th-1 response. This study was performed to determine a possible role of OM-85 BV in triggering autoimmunity in IgAD children within a four-year-follow up period.Sixty-three children (34 males (54%), 29 females (46%)) with sporadic IgAD and recurrent febrile infections were included. Patients were carefully screened for autoimmunity both on admission and in follow-up: Those with autoimmune features or under immunosuppressant treatment were excluded. Patients were randomly divided into two groups: Group I received bacterial lysate propylaxis (OM-85 BV) (n:37), and Group 2 received no prophylactic regimen (n:26). Development of clinical autoimmune findings or autoantibodies (anti-nuclear antibody (ANA), ANA profile (14 antigens), anti-cytoplasmic antibodies (ANCA), anti-cardiolipin antibodies IgG and IgM (aCL), rheumatoid factor (RF), direct Coombs test, anti-thyroglobulin (anti-T) and anti-thyroid microsomal antigen (anti-M)) were evaluated.Mean age of the study group, age at the onset of infectious symptoms and at admission were 102.9±42.2, 27.1±24.9, and 55.2±25.1 months, respectively. Follow-up duration of the whole study group was 48.3±23.1 months. Number of infections was 6.2±2.7 per year in the whole study group. Sixteen patients (25.4%) of the whole study group showed ANA positivity in different patterns and titers. Frequency of ANA, ANCA and RF positivity was 24.3%, 5.4%, 2.7% in Group 1, and 26.9%, 11.5%, 3.8% in Group 2, respectively. Statistical comparisons revealed no significant difference between the two groups.Significant clinical or laboratory markers for autoimmunity in follow-up were not observed between receivers or non-receivers of OM-85 BV. Frequency of ANA positivity was comparable to the previously reported values in IgAD children which was not affected by OM-85 BV usage. Possible effect of triggering autoimmunity with repeated cures of bacterial lysates needs to be further clarified. Side effects requiring the cessation of treatment were not recorded." @default.
• W2017384512 created "2016-06-24" @default.
• W2017384512 creator A5004336829 @default.
• W2017384512 creator A5037180436 @default.
• W2017384512 creator A5043177255 @default.
• W2017384512 creator A5045718313 @default.
• W2017384512 creator A5089524521 @default.
• W2017384512 date "2011-11-01" @default.
• W2017384512 modified "2023-09-26" @default.
• W2017384512 title "Does OM-85 BV prophylaxis trigger autoimmunity in IgA deficient children?" @default.
• W2017384512 cites W1967252020 @default.
• W2017384512 cites W1970802795 @default.
• W2017384512 cites W1971446299 @default.
• W2017384512 cites W1971972737 @default.
• W2017384512 cites W1976657893 @default.
• W2017384512 cites W1979341190 @default.
• W2017384512 cites W2008176536 @default.
• W2017384512 cites W2016736819 @default.
• W2017384512 cites W2017784211 @default.
• W2017384512 cites W2018696588 @default.
• W2017384512 cites W2032228412 @default.
• W2017384512 cites W2039097819 @default.
• W2017384512 cites W2050047704 @default.
• W2017384512 cites W2053133856 @default.
• W2017384512 cites W2060616677 @default.
• W2017384512 cites W2085116183 @default.
• W2017384512 cites W2094161521 @default.
• W2017384512 cites W2094667865 @default.
• W2017384512 cites W2114626700 @default.
• W2017384512 cites W2117483881 @default.
• W2017384512 cites W2123553602 @default.
• W2017384512 cites W2158593444 @default.
• W2017384512 cites W2572233504 @default.
• W2017384512 doi "https://doi.org/10.1016/j.intimp.2011.06.009" @default.
• W2017384512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21771668" @default.
• W2017384512 hasPublicationYear "2011" @default.
• W2017384512 type Work @default.
• W2017384512 sameAs 2017384512 @default.
• W2017384512 citedByCount "14" @default.
• W2017384512 countsByYear W20173845122013 @default.
• W2017384512 countsByYear W20173845122014 @default.
• W2017384512 countsByYear W20173845122015 @default.
• W2017384512 countsByYear W20173845122016 @default.
• W2017384512 countsByYear W20173845122018 @default.
• W2017384512 countsByYear W20173845122019 @default.
• W2017384512 countsByYear W20173845122020 @default.
• W2017384512 countsByYear W20173845122021 @default.
• W2017384512 countsByYear W20173845122022 @default.
• W2017384512 crossrefType "journal-article" @default.
• W2017384512 hasAuthorship W2017384512A5004336829 @default.
• W2017384512 hasAuthorship W2017384512A5037180436 @default.
• W2017384512 hasAuthorship W2017384512A5043177255 @default.
• W2017384512 hasAuthorship W2017384512A5045718313 @default.
• W2017384512 hasAuthorship W2017384512A5089524521 @default.
• W2017384512 hasConcept C126322002 @default.
• W2017384512 hasConcept C147483822 @default.
• W2017384512 hasConcept C149443304 @default.
• W2017384512 hasConcept C159654299 @default.
• W2017384512 hasConcept C163764329 @default.
• W2017384512 hasConcept C203014093 @default.
• W2017384512 hasConcept C2776232647 @default.
• W2017384512 hasConcept C2777910003 @default.
• W2017384512 hasConcept C2780130043 @default.
• W2017384512 hasConcept C71924100 @default.
• W2017384512 hasConcept C90924648 @default.
• W2017384512 hasConceptScore W2017384512C126322002 @default.
• W2017384512 hasConceptScore W2017384512C147483822 @default.
• W2017384512 hasConceptScore W2017384512C149443304 @default.
• W2017384512 hasConceptScore W2017384512C159654299 @default.
• W2017384512 hasConceptScore W2017384512C163764329 @default.
• W2017384512 hasConceptScore W2017384512C203014093 @default.
• W2017384512 hasConceptScore W2017384512C2776232647 @default.
• W2017384512 hasConceptScore W2017384512C2777910003 @default.
• W2017384512 hasConceptScore W2017384512C2780130043 @default.
• W2017384512 hasConceptScore W2017384512C71924100 @default.
• W2017384512 hasConceptScore W2017384512C90924648 @default.
• W2017384512 hasIssue "11" @default.
• W2017384512 hasLocation W20173845121 @default.
• W2017384512 hasLocation W20173845122 @default.
• W2017384512 hasOpenAccess W2017384512 @default.
• W2017384512 hasPrimaryLocation W20173845121 @default.
• W2017384512 hasRelatedWork W178914116 @default.
• W2017384512 hasRelatedWork W1969039009 @default.
• W2017384512 hasRelatedWork W1980206759 @default.
• W2017384512 hasRelatedWork W2009370759 @default.
• W2017384512 hasRelatedWork W2020264988 @default.
• W2017384512 hasRelatedWork W2106513812 @default.
• W2017384512 hasRelatedWork W2401624759 @default.
• W2017384512 hasRelatedWork W2413937440 @default.
• W2017384512 hasRelatedWork W2419972790 @default.
• W2017384512 hasRelatedWork W2982555320 @default.
• W2017384512 hasVolume "11" @default.
• W2017384512 isParatext "false" @default.
• W2017384512 isRetracted "false" @default.
• W2017384512 magId "2017384512" @default.
• W2017384512 workType "article" @default.