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• W2017385614 endingPage "767" @default.
• W2017385614 startingPage "747" @default.
• W2017385614 abstract "Earlier studies have suggested that gastric acid secretion declines with age. Integrated acidity (IA) calculated from ambulatory 24-h pH studies provides an estimation of gastric acid secretion that is less cumbersome than nasogastric aspiration. The aim of this study was to calculate IA as a function of age and gender.In a retrospective study, 753 ambulatory 24-h pH studies from 1994 to 2001 were analyzed. Subjects were classified according to nine age groups: <35 yr (n = 124), 35–39 yr (n = 90), 40–44 yr (n = 92), 45–49 yr (n = 111), 50–54 yr (n = 96), 55–59 yr (n = 61), 60–64 yr (n = 59), 65–69 yr (n = 42), and ≥70 yr (n = 64). Basal integrated acidity (BIA) was defined as IA between 12 midnight and 8 AM when no meals were consumed. Daytime and nocturnal IA/h was measured from 8 AM to 8 PM and from 8 PM to 8 AM. Postprandial IA (PIA) was measured for 2 h after the largest meal peak in each patient.Gender distribution was similar between groups (χ2 = 6.42, 3 df, p = 0.093). Mean gastric pH was similar between genders (2.96 ± 1.36 women; 3.01 ± 1.42 men; p = 0.71). Women and men had similar BIA (361.1 ± 384.1 vs 434.6 ± 436.6 mmol/L/h, p = 0.10), daytime IA (33.5 ± 33.0 vs 34.1 ± 33.7 mmol/L, p = 0.90) and nocturnal IA (43.3 ± 42.1 vs 48.0 ± 46.6 mmol/L, p = 0.42), and PIA (38.2 ± 58.7 vs 36.0 ± 58.5 mmol/L/h, p = 0.47). Mean gastric pH, daytime and nocturnal IA, BIA, and PIA did not differ between age groups (p > 0.1). None of the parameters studied had a linear association with age (mean gastric pH, r = 0.106; BIA, r = −0.124; daytime IA, r = −0.046; nocturnal IA, r = −0.104; PIA, r = −0.117).Based on this study, we conclude that IA is unaffected by gender or age." @default.
• W2017385614 created "2016-06-24" @default.
• W2017385614 creator A5063456232 @default.
• W2017385614 date "1987-10-01" @default.
• W2017385614 modified "2023-10-18" @default.
• W2017385614 title "2 pH Measurement in the oesophagus" @default.
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• W2017385614 doi "https://doi.org/10.1016/0950-3528(87)90017-0" @default.
• W2017385614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3329542" @default.
• W2017385614 hasPublicationYear "1987" @default.
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