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• W2017387225 abstract "ObjectiveSafety and reactogenicity of a new heptavalent DTPw–HBV/Hib–MenAC (diphtheria, tetanus, whole cell pertussis–hepatitis B virus/Haemophilus influenzae type b–Neisseria meningitidis serogroups A and C) vaccine was compared with a widely used pentavalent DTPw–HBV/Hib vaccine.MethodsThree phase III randomized studies comparable in design and methodology, in which healthy infants received DTPw–HBV/Hib–MenAC (N = 1334) or DTPw–HBV/Hib (N = 446) at 2, 4, and 6 months, were pooled for analysis. Solicited symptoms were recorded for 4 days, and unsolicited adverse events for 31 days after each dose. Serious adverse events (SAEs) were recorded throughout the studies.ResultsThere were no significant differences between the two groups in the proportion of subjects with fever >39.5 °C or >40.0 °C (p < 0.005). Compared to group DTPw–HBV/Hib, a significantly higher percentage of subjects in group DTPw–HBV/Hib–MenAC reported fever >39 °C (21.2% vs. 14.8%, p = 0.004). Fever subsided quickly, did not lead to differences in attendance to medical services and did not increase from dose to dose. Sixty-seven SAEs were reported, 56/1334 (4.2%) in group DTPw–HBV/Hib–MenAC and 11/446 (2.5%) in the DTPw–HBV/Hib group.ConclusionOverall, the heptavalent and pentavalent vaccines had similar safety profiles. The difference observed in percentage of subjects with fever >39 °C did not lead to differences in medically attended visits for fever." @default.
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• W2017387225 date "2008-01-01" @default.
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• W2017387225 title "Primary vaccination with a new heptavalent DTPw–HBV/Hib–Neisseria meningitidis serogroups A and C combined vaccine is well tolerated" @default.
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• W2017387225 doi "https://doi.org/10.1016/j.ijid.2007.06.002" @default.
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