FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017387370> ?p ?o ?g. }

• W2017387370 endingPage "82" @default.
• W2017387370 startingPage "74" @default.
• W2017387370 abstract "Inflammatory diseases are highly associated with affective disorders including depression and anxiety. While the role of the innate immune system on emotionality has been extensively studied, the role of adaptive immunity is less understood. Considering that chronic inflammatory conditions are mediated largely by maladaptive lymphocyte function, the role of these cells on brain function and behavior during inflammation warrants investigation. In the present study we employed mice deficient in lymphocyte function and studied behavioral and inflammatory responses during challenge with bacterial lipopolysaccharides (LPS). Rag2−/− mice lacking mature lymphocytes were susceptible to death under sub-septic (5 mg/kg) doses of LPS and survived only to moderate (1 mg/kg) doses of LPS. Under these conditions, they displayed attenuated TNF-alpha responses and behavioral symptoms of sickness when compared with immunocompetent mice. Nevertheless, Rag2−/− mice had protracted motivational impairments after recovery from sickness suggesting a specific function for lymphocytes on the re-establishment of motivational states after activation of the innate immune system. The behavioral impairments in Rag2−/− mice were paralleled by an elevation in plasma corticosterone after behavioral tests. These results provide evidence that the absence of adaptive immunity may be associated with emotional deficits during inflammation and suggest that depressive states associated with medical illness may be mediated in part by impaired lymphocyte responses." @default.
• W2017387370 created "2016-06-24" @default.
• W2017387370 creator A5000995164 @default.
• W2017387370 creator A5020040467 @default.
• W2017387370 creator A5030187911 @default.
• W2017387370 creator A5056181612 @default.
• W2017387370 creator A5065349385 @default.
• W2017387370 creator A5073889692 @default.
• W2017387370 creator A5083207366 @default.
• W2017387370 date "2015-02-01" @default.
• W2017387370 modified "2023-10-12" @default.
• W2017387370 title "Dissociation between sickness behavior and emotionality during lipopolysaccharide challenge in lymphocyte deficient Rag2−/− mice" @default.
• W2017387370 cites W1603370446 @default.
• W2017387370 cites W1849251200 @default.
• W2017387370 cites W1929110414 @default.
• W2017387370 cites W1964368905 @default.
• W2017387370 cites W1965661602 @default.
• W2017387370 cites W1982754908 @default.
• W2017387370 cites W1985819825 @default.
• W2017387370 cites W1987898767 @default.
• W2017387370 cites W1992144053 @default.
• W2017387370 cites W1992350503 @default.
• W2017387370 cites W2002339775 @default.
• W2017387370 cites W2007143131 @default.
• W2017387370 cites W2008202586 @default.
• W2017387370 cites W2013524799 @default.
• W2017387370 cites W2016631812 @default.
• W2017387370 cites W2019233190 @default.
• W2017387370 cites W2020222089 @default.
• W2017387370 cites W2020644616 @default.
• W2017387370 cites W2023941297 @default.
• W2017387370 cites W2025016146 @default.
• W2017387370 cites W2027760005 @default.
• W2017387370 cites W2027867543 @default.
• W2017387370 cites W2034137314 @default.
• W2017387370 cites W2036691044 @default.
• W2017387370 cites W2043943546 @default.
• W2017387370 cites W2049161101 @default.
• W2017387370 cites W2056487354 @default.
• W2017387370 cites W2063026836 @default.
• W2017387370 cites W2065654550 @default.
• W2017387370 cites W2066704028 @default.
• W2017387370 cites W2069742985 @default.
• W2017387370 cites W2074257485 @default.
• W2017387370 cites W2081153657 @default.
• W2017387370 cites W2083497024 @default.
• W2017387370 cites W2083828783 @default.
• W2017387370 cites W2098731039 @default.
• W2017387370 cites W2103071544 @default.
• W2017387370 cites W2107277218 @default.
• W2017387370 cites W2109261715 @default.
• W2017387370 cites W2110729320 @default.
• W2017387370 cites W2117979165 @default.
• W2017387370 cites W2126464081 @default.
• W2017387370 cites W2126795224 @default.
• W2017387370 cites W2128664082 @default.
• W2017387370 cites W2141059794 @default.
• W2017387370 cites W2144290629 @default.
• W2017387370 cites W2149671708 @default.
• W2017387370 cites W2156540153 @default.
• W2017387370 cites W2157874465 @default.
• W2017387370 cites W2170455434 @default.
• W2017387370 doi "https://doi.org/10.1016/j.bbr.2014.09.030" @default.
• W2017387370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4369474" @default.
• W2017387370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25257108" @default.
• W2017387370 hasPublicationYear "2015" @default.
• W2017387370 type Work @default.
• W2017387370 sameAs 2017387370 @default.
• W2017387370 citedByCount "21" @default.
• W2017387370 countsByYear W20173873702015 @default.
• W2017387370 countsByYear W20173873702016 @default.
• W2017387370 countsByYear W20173873702018 @default.
• W2017387370 countsByYear W20173873702019 @default.
• W2017387370 countsByYear W20173873702020 @default.
• W2017387370 countsByYear W20173873702021 @default.
• W2017387370 countsByYear W20173873702022 @default.
• W2017387370 countsByYear W20173873702023 @default.
• W2017387370 crossrefType "journal-article" @default.
• W2017387370 hasAuthorship W2017387370A5000995164 @default.
• W2017387370 hasAuthorship W2017387370A5020040467 @default.
• W2017387370 hasAuthorship W2017387370A5030187911 @default.
• W2017387370 hasAuthorship W2017387370A5056181612 @default.
• W2017387370 hasAuthorship W2017387370A5065349385 @default.
• W2017387370 hasAuthorship W2017387370A5073889692 @default.
• W2017387370 hasAuthorship W2017387370A5083207366 @default.
• W2017387370 hasBestOaLocation W20173873702 @default.
• W2017387370 hasConcept C118552586 @default.
• W2017387370 hasConcept C134018914 @default.
• W2017387370 hasConcept C136449434 @default.
• W2017387370 hasConcept C138906646 @default.
• W2017387370 hasConcept C15744967 @default.
• W2017387370 hasConcept C168862018 @default.
• W2017387370 hasConcept C169760540 @default.
• W2017387370 hasConcept C193419808 @default.
• W2017387370 hasConcept C203014093 @default.
• W2017387370 hasConcept C2776914184 @default.
• W2017387370 hasConcept C2777761686 @default.
• W2017387370 hasConcept C2778754761 @default.

• next