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- W2017387524 abstract "Chronic methamphetamine abuse is associated with disruption of frontostriatal function involving serotonin and dopamine circuitry. Clinically, methamphetamine-dependent (MD) individuals are highly distractible and have difficulty focussing. Here, we used a computerized single-trial version of the Stroop Test to examine selective attention and priming in MD. Subject groups comprised eight MD men (31.7+/-7.2 years of age), who had used methamphetamine for 15.75+/-8.4 years but were currently abstinent for 2-4 months, and 12 controls (35.7+9.7 years of age). Compared with the control group, the MD group exhibited significantly greater interference (P<0.05) despite intact priming. Error rates did not differ between the groups. This preliminary finding of reduced cognitive inhibition in MD individuals is consistent with the distractibility they show clinically. Furthermore, the dissociation between explicit attentional performance and priming effects suggests that some attentional functions are not as affected by long-term methamphetamine use as others." @default.
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- W2017387524 date "2002-08-01" @default.
- W2017387524 modified "2023-10-16" @default.
- W2017387524 title "Preliminary evidence of reduced cognitive inhibition in methamphetamine-dependent individuals" @default.
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- W2017387524 doi "https://doi.org/10.1016/s0165-1781(02)00111-7" @default.
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