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- W2017387652 endingPage "514" @default.
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- W2017387652 abstract "Some Mannich bases of 7-hydroxycoumarin (2) and their simple derivatives (3 and 4) were prepared and tested against viruses containing single-stranded, positive-sense RNA genomes (ssRNA+). This study was directed toward Flaviviridae and, in particular, HCV surrogate viruses (BVDV, YFV). The 7-hydroxy derivatives 2 were generally devoid of activity, but when position 7 was propylated, the resulting 7-propyloxy derivatives 3 were in some cases endowed with an interesting activity against BVDV. The formation of 7-benzoyl derivatives 4 gave compounds generally lacking in activity against Flaviviridae, whereas the appearance of activity against RSV has been observed. Also some unsymmetrical methylene derivatives 5–7 (namely coumarins bridged to chromones or indoles) were found moderately active in antiviral tests. Derivatives 3 were submitted to a molecular modeling study using DNA polymerase of HCV as a target. The good correlation between calculated molecular modeling IC50 and experimental EC50 indicates that DNA polymerase is potentially involved in the inhibition of surrogate HCV viruses." @default.
- W2017387652 created "2016-06-24" @default.
- W2017387652 creator A5011344224 @default.
- W2017387652 creator A5037948361 @default.
- W2017387652 creator A5057677366 @default.
- W2017387652 date "1997-11-01" @default.
- W2017387652 modified "2023-10-16" @default.
- W2017387652 title "VIROLOGY OF HEPATITIS C VIRUS" @default.
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