FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017391462> ?p ?o ?g. }

• W2017391462 endingPage "482" @default.
• W2017391462 startingPage "476" @default.
• W2017391462 abstract "Abstract Triethylene glycol dimethacrylate (TEGDMA) is a dentin‐bonding agent and a major component of various dental restorative biomaterials. TEGDMA monomers are released from dental resins and induce dental pulp inflammation and necrosis. In this study, we have investigated the mechanism of TEGDMA–induced cytotoxicity of fibroblasts. Treatment of cultured human gingival and pulpal fibroblasts with 0.1–3 m M of TEGDMA for 24 h induced a concentration–dependent and variable cytotoxic effect. Fifty percent of toxicity (TC 50 ) was obtained with 1.2 ± 0.9 and 2.6 ± 1.1 m M of TEGDMA for gingival and pulpal fibroblasts, respectively. Moreover, TEGDMA‐induced cytotoxicity was associated with an early and drastic depletion of cellular glutathione (GSH), which started at 15–30 min and was almost complete at 4–6 h. Antioxidants, such as Trolox (0.01 m M ), ascorbate (0.2 m M ), and N‐acetylcysteine (NAC) (5 m M ) prevented the TEGDMA‐induced cytotoxicity while GSH depletion was partially inhibited. Finally, a late production of reactive oxygen species (ROS) occurred in fibroblasts treated with TEGDMA for 3–4 h, as determined by 2′,7′‐dichlorofluorescein fluorescence, and was completely inhibited by Trolox (5 μ M ). The data show that TEGDMA induced a drastic GSH depletion followed by production of ROS, which may contribute to the toxicity of gingival and pulpal fibroblasts. Antioxidants, such as NAC, ascorbate, and particularly Trolox, appear useful in preventing cell damage mediated by resin‐containing dental restorative materials. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A: 476–482, 2003" @default.
• W2017391462 created "2016-06-24" @default.
• W2017391462 creator A5000077022 @default.
• W2017391462 creator A5012079890 @default.
• W2017391462 creator A5023839767 @default.
• W2017391462 creator A5059053740 @default.
• W2017391462 creator A5062770471 @default.
• W2017391462 creator A5070787008 @default.
• W2017391462 date "2003-07-22" @default.
• W2017391462 modified "2023-10-17" @default.
• W2017391462 title "TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species" @default.
• W2017391462 cites W1928222724 @default.
• W2017391462 cites W1965261878 @default.
• W2017391462 cites W1972924335 @default.
• W2017391462 cites W1974936963 @default.
• W2017391462 cites W1977406521 @default.
• W2017391462 cites W1986159986 @default.
• W2017391462 cites W1995317658 @default.
• W2017391462 cites W1999977358 @default.
• W2017391462 cites W2032735131 @default.
• W2017391462 cites W2044965826 @default.
• W2017391462 cites W2046317324 @default.
• W2017391462 cites W2057526737 @default.
• W2017391462 cites W2063576996 @default.
• W2017391462 cites W2068808589 @default.
• W2017391462 cites W2090220251 @default.
• W2017391462 cites W2093163930 @default.
• W2017391462 cites W2094523616 @default.
• W2017391462 cites W2094829500 @default.
• W2017391462 cites W2105370577 @default.
• W2017391462 cites W2108933664 @default.
• W2017391462 cites W2135596829 @default.
• W2017391462 cites W2167824091 @default.
• W2017391462 doi "https://doi.org/10.1002/jbm.a.10600" @default.
• W2017391462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12918029" @default.
• W2017391462 hasPublicationYear "2003" @default.
• W2017391462 type Work @default.
• W2017391462 sameAs 2017391462 @default.
• W2017391462 citedByCount "197" @default.
• W2017391462 countsByYear W20173914622012 @default.
• W2017391462 countsByYear W20173914622013 @default.
• W2017391462 countsByYear W20173914622014 @default.
• W2017391462 countsByYear W20173914622015 @default.
• W2017391462 countsByYear W20173914622016 @default.
• W2017391462 countsByYear W20173914622017 @default.
• W2017391462 countsByYear W20173914622018 @default.
• W2017391462 countsByYear W20173914622019 @default.
• W2017391462 countsByYear W20173914622020 @default.
• W2017391462 countsByYear W20173914622021 @default.
• W2017391462 countsByYear W20173914622022 @default.
• W2017391462 countsByYear W20173914622023 @default.
• W2017391462 crossrefType "journal-article" @default.
• W2017391462 hasAuthorship W2017391462A5000077022 @default.
• W2017391462 hasAuthorship W2017391462A5012079890 @default.
• W2017391462 hasAuthorship W2017391462A5023839767 @default.
• W2017391462 hasAuthorship W2017391462A5059053740 @default.
• W2017391462 hasAuthorship W2017391462A5062770471 @default.
• W2017391462 hasAuthorship W2017391462A5070787008 @default.
• W2017391462 hasConcept C109316439 @default.
• W2017391462 hasConcept C12554922 @default.
• W2017391462 hasConcept C178790620 @default.
• W2017391462 hasConcept C181199279 @default.
• W2017391462 hasConcept C185592680 @default.
• W2017391462 hasConcept C192562407 @default.
• W2017391462 hasConcept C202751555 @default.
• W2017391462 hasConcept C2776151105 @default.
• W2017391462 hasConcept C2776231299 @default.
• W2017391462 hasConcept C2777476445 @default.
• W2017391462 hasConcept C2778004101 @default.
• W2017391462 hasConcept C2779964046 @default.
• W2017391462 hasConcept C29730261 @default.
• W2017391462 hasConcept C2986274086 @default.
• W2017391462 hasConcept C2993539680 @default.
• W2017391462 hasConcept C31903555 @default.
• W2017391462 hasConcept C48349386 @default.
• W2017391462 hasConcept C538909803 @default.
• W2017391462 hasConcept C55493867 @default.
• W2017391462 hasConcept C86803240 @default.
• W2017391462 hasConcept C98274493 @default.
• W2017391462 hasConceptScore W2017391462C109316439 @default.
• W2017391462 hasConceptScore W2017391462C12554922 @default.
• W2017391462 hasConceptScore W2017391462C178790620 @default.
• W2017391462 hasConceptScore W2017391462C181199279 @default.
• W2017391462 hasConceptScore W2017391462C185592680 @default.
• W2017391462 hasConceptScore W2017391462C192562407 @default.
• W2017391462 hasConceptScore W2017391462C202751555 @default.
• W2017391462 hasConceptScore W2017391462C2776151105 @default.
• W2017391462 hasConceptScore W2017391462C2776231299 @default.
• W2017391462 hasConceptScore W2017391462C2777476445 @default.
• W2017391462 hasConceptScore W2017391462C2778004101 @default.
• W2017391462 hasConceptScore W2017391462C2779964046 @default.
• W2017391462 hasConceptScore W2017391462C29730261 @default.
• W2017391462 hasConceptScore W2017391462C2986274086 @default.
• W2017391462 hasConceptScore W2017391462C2993539680 @default.
• W2017391462 hasConceptScore W2017391462C31903555 @default.
• W2017391462 hasConceptScore W2017391462C48349386 @default.
• W2017391462 hasConceptScore W2017391462C538909803 @default.
• W2017391462 hasConceptScore W2017391462C55493867 @default.

• next