FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017392124> ?p ?o ?g. }

• W2017392124 endingPage "104" @default.
• W2017392124 startingPage "91" @default.
• W2017392124 abstract "Cleavage/polyadenylation of mRNAs and 3′ processing of replication-dependent histone transcripts are both mediated by large complexes that share several protein components. Functional studies of these shared proteins are complicated by the cooperative binding of the individual subunits. For CstF-64, an additional difficulty is that symplekin and CstF-77 bind mutually exclusively to its hinge domain. Here we have identified CstF-64 and symplekin mutants that allowed us to distinguish between these interactions and to elucidate the role of CstF-64 in the two processing reactions. The interaction of CstF-64 with symplekin is limiting for histone RNA 3′ processing but relatively unimportant for cleavage/polyadenylation. In contrast, the nuclear accumulation of CstF-64 depends on its binding to CstF-77 and not to symplekin. Moreover, the CstF-64 paralogue CstF-64Tau can compensate for the loss of CstF-64. As CstF-64Tau has a lower affinity for CstF-77 than CstF-64 and is relatively unstable, it is the minor form. However, it may become up-regulated when the CstF-64 level decreases, which has biological implications for spermatogenesis and probably also for other regulatory events. Thus, the interactions between CstF-64/CstF-64Tau and CstF-77 are important for the maintenance of stoichiometric nuclear levels of the CstF complex components and for their intracellular localization, stability, and function." @default.
• W2017392124 created "2016-06-24" @default.
• W2017392124 creator A5064619680 @default.
• W2017392124 creator A5070054212 @default.
• W2017392124 creator A5081898908 @default.
• W2017392124 creator A5087672103 @default.
• W2017392124 date "2011-01-01" @default.
• W2017392124 modified "2023-09-27" @default.
• W2017392124 title "Interactions of CstF-64, CstF-77, and symplekin: Implications on localisation and function" @default.
• W2017392124 cites W10653369 @default.
• W2017392124 cites W1972208485 @default.
• W2017392124 cites W1972685122 @default.
• W2017392124 cites W1975572355 @default.
• W2017392124 cites W1975586512 @default.
• W2017392124 cites W1995987769 @default.
• W2017392124 cites W2005964874 @default.
• W2017392124 cites W2015562197 @default.
• W2017392124 cites W2027784918 @default.
• W2017392124 cites W2032749894 @default.
• W2017392124 cites W2038092452 @default.
• W2017392124 cites W2038424676 @default.
• W2017392124 cites W2038783205 @default.
• W2017392124 cites W2044146927 @default.
• W2017392124 cites W2044774520 @default.
• W2017392124 cites W2049541097 @default.
• W2017392124 cites W2065530211 @default.
• W2017392124 cites W2065813594 @default.
• W2017392124 cites W2071749819 @default.
• W2017392124 cites W2076124785 @default.
• W2017392124 cites W2079932405 @default.
• W2017392124 cites W2080629081 @default.
• W2017392124 cites W2089732199 @default.
• W2017392124 cites W2093295511 @default.
• W2017392124 cites W2105144439 @default.
• W2017392124 cites W2107176055 @default.
• W2017392124 cites W2107939738 @default.
• W2017392124 cites W2108244474 @default.
• W2017392124 cites W2110946097 @default.
• W2017392124 cites W2111005893 @default.
• W2017392124 cites W2151252259 @default.
• W2017392124 cites W2152081451 @default.
• W2017392124 cites W2152470748 @default.
• W2017392124 cites W2154320306 @default.
• W2017392124 cites W2155234110 @default.
• W2017392124 cites W2159666069 @default.
• W2017392124 cites W2170234615 @default.
• W2017392124 doi "https://doi.org/10.1091/mbc.e10-06-0543" @default.
• W2017392124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3016980" @default.
• W2017392124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21119002" @default.
• W2017392124 hasPublicationYear "2011" @default.
• W2017392124 type Work @default.
• W2017392124 sameAs 2017392124 @default.
• W2017392124 citedByCount "51" @default.
• W2017392124 countsByYear W20173921242012 @default.
• W2017392124 countsByYear W20173921242013 @default.
• W2017392124 countsByYear W20173921242014 @default.
• W2017392124 countsByYear W20173921242015 @default.
• W2017392124 countsByYear W20173921242016 @default.
• W2017392124 countsByYear W20173921242017 @default.
• W2017392124 countsByYear W20173921242018 @default.
• W2017392124 countsByYear W20173921242019 @default.
• W2017392124 countsByYear W20173921242020 @default.
• W2017392124 countsByYear W20173921242021 @default.
• W2017392124 countsByYear W20173921242022 @default.
• W2017392124 countsByYear W20173921242023 @default.
• W2017392124 crossrefType "journal-article" @default.
• W2017392124 hasAuthorship W2017392124A5064619680 @default.
• W2017392124 hasAuthorship W2017392124A5070054212 @default.
• W2017392124 hasAuthorship W2017392124A5081898908 @default.
• W2017392124 hasAuthorship W2017392124A5087672103 @default.
• W2017392124 hasBestOaLocation W20173921241 @default.
• W2017392124 hasConcept C104317684 @default.
• W2017392124 hasConcept C105580179 @default.
• W2017392124 hasConcept C142575336 @default.
• W2017392124 hasConcept C55493867 @default.
• W2017392124 hasConcept C62531158 @default.
• W2017392124 hasConcept C67492840 @default.
• W2017392124 hasConcept C86803240 @default.
• W2017392124 hasConcept C95444343 @default.
• W2017392124 hasConceptScore W2017392124C104317684 @default.
• W2017392124 hasConceptScore W2017392124C105580179 @default.
• W2017392124 hasConceptScore W2017392124C142575336 @default.
• W2017392124 hasConceptScore W2017392124C55493867 @default.
• W2017392124 hasConceptScore W2017392124C62531158 @default.
• W2017392124 hasConceptScore W2017392124C67492840 @default.
• W2017392124 hasConceptScore W2017392124C86803240 @default.
• W2017392124 hasConceptScore W2017392124C95444343 @default.
• W2017392124 hasIssue "1" @default.
• W2017392124 hasLocation W20173921241 @default.
• W2017392124 hasLocation W20173921242 @default.
• W2017392124 hasLocation W20173921243 @default.
• W2017392124 hasLocation W20173921244 @default.
• W2017392124 hasLocation W20173921245 @default.
• W2017392124 hasOpenAccess W2017392124 @default.
• W2017392124 hasPrimaryLocation W20173921241 @default.
• W2017392124 hasRelatedWork W1488258440 @default.
• W2017392124 hasRelatedWork W1787193294 @default.
• W2017392124 hasRelatedWork W2026168910 @default.

• next