FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017393871> ?p ?o ?g. }

• W2017393871 endingPage "33" @default.
• W2017393871 startingPage "25" @default.
• W2017393871 abstract "Many studies have linked ambient fine particulate matter (PM2.5) air pollution to different cardiopulmonary diseases in the general population. However the complex mechanisms underlying PM2.5-induced adverse health effects are not yet to be fully elucidated. In this study, we aimed to identify genes and pathways that may contribute to PM2.5-induced lung toxicity in humans through genome-wide approaches. Human bronchial epithelial (HBE) cells, exposed to various concentrations of PM2.5 collected from Wuhan, China, showed decreased cell viability in a dose-dependent manner. HBE cells were exposed to 200 μg/ml and 500 μg/ml PM2.5 and microarrays were used to obtain a global view of the transcriptomic responses. A total of 970 and 492 genes were identified that significantly changed after 200 μg/ml and 500 μg/ml PM2.5 exposures, respectively. PM2.5 induced a large number of genes involved in inflammatory and immune response, response to oxidative stress, and response to DNA damage stimulus, which might contribute to PM2.5 related cardiopulmonary diseases. Pathway analysis revealed that different dose of PM2.5 triggered partially common disturbed pathways. Flow cytometry assay evidenced that there were statistically significant differences in the G1 phase of cell cycle after low or high-dose PM2.5 exposure when compared to the unexposed controls. Only high-dose PM2.5 significantly increased the proportion of cells in the S phase of cell cycle. We identified many genes and pathways that altered significantly in HBE cells after PM2.5 exposures. These findings are important in providing further understanding of the mechanisms underlying PM2.5-induced adverse health effects." @default.
• W2017393871 created "2016-06-24" @default.
• W2017393871 creator A5006617799 @default.
• W2017393871 creator A5011363966 @default.
• W2017393871 creator A5012266709 @default.
• W2017393871 creator A5027448067 @default.
• W2017393871 creator A5028256671 @default.
• W2017393871 creator A5039144070 @default.
• W2017393871 creator A5039558767 @default.
• W2017393871 creator A5054009327 @default.
• W2017393871 creator A5054062342 @default.
• W2017393871 creator A5065800913 @default.
• W2017393871 creator A5065836602 @default.
• W2017393871 creator A5071352325 @default.
• W2017393871 creator A5077469902 @default.
• W2017393871 creator A5084075381 @default.
• W2017393871 creator A5084213516 @default.
• W2017393871 date "2014-07-01" @default.
• W2017393871 modified "2023-10-14" @default.
• W2017393871 title "Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China" @default.
• W2017393871 cites W1493240590 @default.
• W2017393871 cites W1967528284 @default.
• W2017393871 cites W1969463506 @default.
• W2017393871 cites W1969622344 @default.
• W2017393871 cites W1975064981 @default.
• W2017393871 cites W1979331393 @default.
• W2017393871 cites W1993436403 @default.
• W2017393871 cites W1995428293 @default.
• W2017393871 cites W2024908526 @default.
• W2017393871 cites W2032791321 @default.
• W2017393871 cites W2036361694 @default.
• W2017393871 cites W2040658267 @default.
• W2017393871 cites W2047047744 @default.
• W2017393871 cites W2049048127 @default.
• W2017393871 cites W2051273313 @default.
• W2017393871 cites W2051965749 @default.
• W2017393871 cites W2053911859 @default.
• W2017393871 cites W2057808762 @default.
• W2017393871 cites W2064245899 @default.
• W2017393871 cites W2079434650 @default.
• W2017393871 cites W2082662545 @default.
• W2017393871 cites W2085973801 @default.
• W2017393871 cites W2092776294 @default.
• W2017393871 cites W2095916340 @default.
• W2017393871 cites W2097207761 @default.
• W2017393871 cites W2098950066 @default.
• W2017393871 cites W2100472018 @default.
• W2017393871 cites W2102512870 @default.
• W2017393871 cites W2108819906 @default.
• W2017393871 cites W2110052313 @default.
• W2017393871 cites W2127986157 @default.
• W2017393871 cites W2130292493 @default.
• W2017393871 cites W2140282454 @default.
• W2017393871 cites W2144112254 @default.
• W2017393871 cites W2146993998 @default.
• W2017393871 cites W2153891578 @default.
• W2017393871 cites W2156983792 @default.
• W2017393871 cites W2322982668 @default.
• W2017393871 cites W2331396985 @default.
• W2017393871 cites W2519272334 @default.
• W2017393871 doi "https://doi.org/10.1016/j.toxlet.2014.04.010" @default.
• W2017393871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24769257" @default.
• W2017393871 hasPublicationYear "2014" @default.
• W2017393871 type Work @default.
• W2017393871 sameAs 2017393871 @default.
• W2017393871 citedByCount "57" @default.
• W2017393871 countsByYear W20173938712014 @default.
• W2017393871 countsByYear W20173938712015 @default.
• W2017393871 countsByYear W20173938712016 @default.
• W2017393871 countsByYear W20173938712017 @default.
• W2017393871 countsByYear W20173938712018 @default.
• W2017393871 countsByYear W20173938712019 @default.
• W2017393871 countsByYear W20173938712020 @default.
• W2017393871 countsByYear W20173938712021 @default.
• W2017393871 countsByYear W20173938712022 @default.
• W2017393871 countsByYear W20173938712023 @default.
• W2017393871 crossrefType "journal-article" @default.
• W2017393871 hasAuthorship W2017393871A5006617799 @default.
• W2017393871 hasAuthorship W2017393871A5011363966 @default.
• W2017393871 hasAuthorship W2017393871A5012266709 @default.
• W2017393871 hasAuthorship W2017393871A5027448067 @default.
• W2017393871 hasAuthorship W2017393871A5028256671 @default.
• W2017393871 hasAuthorship W2017393871A5039144070 @default.
• W2017393871 hasAuthorship W2017393871A5039558767 @default.
• W2017393871 hasAuthorship W2017393871A5054009327 @default.
• W2017393871 hasAuthorship W2017393871A5054062342 @default.
• W2017393871 hasAuthorship W2017393871A5065800913 @default.
• W2017393871 hasAuthorship W2017393871A5065836602 @default.
• W2017393871 hasAuthorship W2017393871A5071352325 @default.
• W2017393871 hasAuthorship W2017393871A5077469902 @default.
• W2017393871 hasAuthorship W2017393871A5084075381 @default.
• W2017393871 hasAuthorship W2017393871A5084213516 @default.
• W2017393871 hasConcept C104317684 @default.
• W2017393871 hasConcept C143425029 @default.
• W2017393871 hasConcept C150194340 @default.
• W2017393871 hasConcept C153911025 @default.
• W2017393871 hasConcept C162317418 @default.
• W2017393871 hasConcept C18431079 @default.

• next