FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017394485> ?p ?o ?g. }

• W2017394485 endingPage "95" @default.
• W2017394485 startingPage "85" @default.
• W2017394485 abstract "In a search for genes that modify iron homoeostasis, a gene (1300017J02Rik) was located immediately upstream of the murine TF (transferrin) gene. However, expression of the 1300017J02Rik gene product was not responsive to a number of modulators of iron metabolism. Specifically, expression was not altered in mouse models of iron disorders including mice with deficiencies in the haemochromatosis protein Hfe, the recombination-activating protein, Rag, β2-microglobulin, TF, ceruloplasmin or Hb, or in mice with microcytic anaemia. Additionally, neither lipopolysaccharide nor hypoxia treatment resulted in any significant changes in the 1300017J02Rik expression level. The genomic DNA sequence suggested that the 1300017J02Rik gene product might be a protein equivalent to the pICA {porcine ICA [inhibitor of CA (carbonic anhydrase)]}. The coding region for the murine 1300017J02Rik gene was placed into the pNUT expression vector. Transformed BHK cells (baby-hamster kidney cells) were transfected with this plasmid, resulting in secretion of recombinant mICA (murine ICA) into the tissue culture medium. Following purification to homogeneity, the yield of mICA from the BHK cells was found to be considerably greater (at least 4-fold) than the yield of pICA from a previously reported Pichia pastoris (yeast) expression system. MS showed that the recombinant mICA was a glycoprotein that associated with CA in a 1:1 stoichiometry. Despite its high sequence similarity to TF, titration experiments showed that mICA was unable to bind iron specifically. Although enzymatic assays revealed that mICA was able to inhibit CA, it is unclear if this is its sole or even its major function since, to date, humans and other primates appear to lack functional ICA. Lastly, we note that this member of the TF superfamily is a relatively recent addition resulting from a tandem duplication event." @default.
• W2017394485 created "2016-06-24" @default.
• W2017394485 creator A5001719050 @default.
• W2017394485 creator A5013783603 @default.
• W2017394485 creator A5024553725 @default.
• W2017394485 creator A5025911192 @default.
• W2017394485 creator A5031320671 @default.
• W2017394485 creator A5038635870 @default.
• W2017394485 creator A5070800706 @default.
• W2017394485 creator A5084835430 @default.
• W2017394485 creator A5085169069 @default.
• W2017394485 creator A5091183628 @default.
• W2017394485 date "2007-07-26" @default.
• W2017394485 modified "2023-09-23" @default.
• W2017394485 title "A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase" @default.
• W2017394485 cites W1487680459 @default.
• W2017394485 cites W1499054486 @default.
• W2017394485 cites W1541406253 @default.
• W2017394485 cites W1551307287 @default.
• W2017394485 cites W1588054335 @default.
• W2017394485 cites W1848059939 @default.
• W2017394485 cites W1965966260 @default.
• W2017394485 cites W1971734444 @default.
• W2017394485 cites W1975380286 @default.
• W2017394485 cites W1976009198 @default.
• W2017394485 cites W1980307155 @default.
• W2017394485 cites W1982831087 @default.
• W2017394485 cites W1983891046 @default.
• W2017394485 cites W1987339366 @default.
• W2017394485 cites W1989144043 @default.
• W2017394485 cites W1990330893 @default.
• W2017394485 cites W1997382456 @default.
• W2017394485 cites W2001776577 @default.
• W2017394485 cites W2004067151 @default.
• W2017394485 cites W2017583890 @default.
• W2017394485 cites W2025812024 @default.
• W2017394485 cites W2026455613 @default.
• W2017394485 cites W2029683748 @default.
• W2017394485 cites W2034861500 @default.
• W2017394485 cites W2046818843 @default.
• W2017394485 cites W2048285411 @default.
• W2017394485 cites W2052640429 @default.
• W2017394485 cites W2057341054 @default.
• W2017394485 cites W2058310290 @default.
• W2017394485 cites W2058382755 @default.
• W2017394485 cites W2059519530 @default.
• W2017394485 cites W2060022769 @default.
• W2017394485 cites W2066036014 @default.
• W2017394485 cites W2069358267 @default.
• W2017394485 cites W2073618740 @default.
• W2017394485 cites W2076199852 @default.
• W2017394485 cites W2082806735 @default.
• W2017394485 cites W2086277446 @default.
• W2017394485 cites W2087517456 @default.
• W2017394485 cites W2090798601 @default.
• W2017394485 cites W2101803710 @default.
• W2017394485 cites W2104017463 @default.
• W2017394485 cites W2104708113 @default.
• W2017394485 cites W2106560790 @default.
• W2017394485 cites W2108156627 @default.
• W2017394485 cites W2108787198 @default.
• W2017394485 cites W2109637818 @default.
• W2017394485 cites W2121815724 @default.
• W2017394485 cites W2145564117 @default.
• W2017394485 cites W2146396346 @default.
• W2017394485 cites W2161918511 @default.
• W2017394485 cites W2426242415 @default.
• W2017394485 cites W2416156959 @default.
• W2017394485 doi "https://doi.org/10.1042/bj20070384" @default.
• W2017394485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1948979" @default.
• W2017394485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17511619" @default.
• W2017394485 hasPublicationYear "2007" @default.
• W2017394485 type Work @default.
• W2017394485 sameAs 2017394485 @default.
• W2017394485 citedByCount "13" @default.
• W2017394485 countsByYear W20173944852012 @default.
• W2017394485 countsByYear W20173944852014 @default.
• W2017394485 countsByYear W20173944852019 @default.
• W2017394485 countsByYear W20173944852020 @default.
• W2017394485 countsByYear W20173944852022 @default.
• W2017394485 crossrefType "journal-article" @default.
• W2017394485 hasAuthorship W2017394485A5001719050 @default.
• W2017394485 hasAuthorship W2017394485A5013783603 @default.
• W2017394485 hasAuthorship W2017394485A5024553725 @default.
• W2017394485 hasAuthorship W2017394485A5025911192 @default.
• W2017394485 hasAuthorship W2017394485A5031320671 @default.
• W2017394485 hasAuthorship W2017394485A5038635870 @default.
• W2017394485 hasAuthorship W2017394485A5070800706 @default.
• W2017394485 hasAuthorship W2017394485A5084835430 @default.
• W2017394485 hasAuthorship W2017394485A5085169069 @default.
• W2017394485 hasAuthorship W2017394485A5091183628 @default.
• W2017394485 hasBestOaLocation W20173944852 @default.
• W2017394485 hasConcept C104317684 @default.
• W2017394485 hasConcept C150194340 @default.
• W2017394485 hasConcept C153911025 @default.
• W2017394485 hasConcept C181199279 @default.
• W2017394485 hasConcept C185592680 @default.
• W2017394485 hasConcept C203014093 @default.

• next