FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017394938> ?p ?o ?g. }

• W2017394938 endingPage "14800" @default.
• W2017394938 startingPage "14795" @default.
• W2017394938 abstract "For numerous enzymes reactive toward small gaseous compounds, growing evidence indicates that these substrates diffuse into active site pockets through defined pathways in the protein matrix. Toluene/ o -xylene monooxygenase hydroxylase is a dioxygen-activating enzyme. Structural analysis suggests two possible pathways for dioxygen access through the α-subunit to the diiron center: a channel or a series of hydrophobic cavities. To distinguish which is utilized as the O 2 migration pathway, the dimensions of the cavities and the channel were independently varied by site-directed mutagenesis and confirmed by X-ray crystallography. The rate constants for dioxygen access to the diiron center were derived from the formation rates of a peroxodiiron(III) intermediate, generated upon treatment of the diiron(II) enzyme with O 2 . This reaction depends on the concentration of dioxygen to the first order. Altering the dimensions of the cavities, but not the channel, changed the rate of dioxygen reactivity with the enzyme. These results strongly suggest that voids comprising the cavities in toluene/ o -xylene monooxygenase hydroxylase are not artifacts of protein packing/folding, but rather programmed routes for dioxygen migration through the protein matrix. Because the cavities are not fully connected into the diiron active center in the enzyme resting state, conformational changes will be required to facilitate dioxygen access to the diiron center. We propose that such temporary opening and closing of the cavities may occur in all bacterial multicomponent monooxygenases to control O 2 consumption for efficient catalysis. Our findings suggest that other gas-utilizing enzymes may employ similar structural features to effect substrate passage through a protein matrix." @default.
• W2017394938 created "2016-06-24" @default.
• W2017394938 creator A5007664443 @default.
• W2017394938 creator A5034625027 @default.
• W2017394938 creator A5035435057 @default.
• W2017394938 creator A5039312032 @default.
• W2017394938 date "2011-08-22" @default.
• W2017394938 modified "2023-10-11" @default.
• W2017394938 title "Tracking a defined route for O ₂ migration in a dioxygen-activating diiron enzyme" @default.
• W2017394938 cites W1513686768 @default.
• W2017394938 cites W1547482025 @default.
• W2017394938 cites W1964174013 @default.
• W2017394938 cites W1971302449 @default.
• W2017394938 cites W1981704948 @default.
• W2017394938 cites W1983644317 @default.
• W2017394938 cites W1990134274 @default.
• W2017394938 cites W1991324143 @default.
• W2017394938 cites W1993430877 @default.
• W2017394938 cites W2002551641 @default.
• W2017394938 cites W2005896064 @default.
• W2017394938 cites W2005986251 @default.
• W2017394938 cites W2010425549 @default.
• W2017394938 cites W2011607516 @default.
• W2017394938 cites W2014935712 @default.
• W2017394938 cites W2027560458 @default.
• W2017394938 cites W2037913479 @default.
• W2017394938 cites W2041289411 @default.
• W2017394938 cites W2053009800 @default.
• W2017394938 cites W2063043621 @default.
• W2017394938 cites W2064887759 @default.
• W2017394938 cites W2071595256 @default.
• W2017394938 cites W2074900355 @default.
• W2017394938 cites W2085998981 @default.
• W2017394938 cites W2110824209 @default.
• W2017394938 cites W2112868721 @default.
• W2017394938 cites W2146878046 @default.
• W2017394938 cites W2149866648 @default.
• W2017394938 cites W2150287139 @default.
• W2017394938 cites W2161929344 @default.
• W2017394938 cites W2172150348 @default.
• W2017394938 cites W2300367298 @default.
• W2017394938 cites W2314040941 @default.
• W2017394938 doi "https://doi.org/10.1073/pnas.1106514108" @default.
• W2017394938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3169157" @default.
• W2017394938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21859951" @default.
• W2017394938 hasPublicationYear "2011" @default.
• W2017394938 type Work @default.
• W2017394938 sameAs 2017394938 @default.
• W2017394938 citedByCount "27" @default.
• W2017394938 countsByYear W20173949382012 @default.
• W2017394938 countsByYear W20173949382013 @default.
• W2017394938 countsByYear W20173949382014 @default.
• W2017394938 countsByYear W20173949382015 @default.
• W2017394938 countsByYear W20173949382016 @default.
• W2017394938 countsByYear W20173949382018 @default.
• W2017394938 countsByYear W20173949382019 @default.
• W2017394938 countsByYear W20173949382020 @default.
• W2017394938 countsByYear W20173949382021 @default.
• W2017394938 countsByYear W20173949382022 @default.
• W2017394938 countsByYear W20173949382023 @default.
• W2017394938 crossrefType "journal-article" @default.
• W2017394938 hasAuthorship W2017394938A5007664443 @default.
• W2017394938 hasAuthorship W2017394938A5034625027 @default.
• W2017394938 hasAuthorship W2017394938A5035435057 @default.
• W2017394938 hasAuthorship W2017394938A5039312032 @default.
• W2017394938 hasBestOaLocation W20173949381 @default.
• W2017394938 hasConcept C13002179 @default.
• W2017394938 hasConcept C161790260 @default.
• W2017394938 hasConcept C181199279 @default.
• W2017394938 hasConcept C185592680 @default.
• W2017394938 hasConcept C23296010 @default.
• W2017394938 hasConcept C41183919 @default.
• W2017394938 hasConcept C526171541 @default.
• W2017394938 hasConcept C55493867 @default.
• W2017394938 hasConcept C71240020 @default.
• W2017394938 hasConceptScore W2017394938C13002179 @default.
• W2017394938 hasConceptScore W2017394938C161790260 @default.
• W2017394938 hasConceptScore W2017394938C181199279 @default.
• W2017394938 hasConceptScore W2017394938C185592680 @default.
• W2017394938 hasConceptScore W2017394938C23296010 @default.
• W2017394938 hasConceptScore W2017394938C41183919 @default.
• W2017394938 hasConceptScore W2017394938C526171541 @default.
• W2017394938 hasConceptScore W2017394938C55493867 @default.
• W2017394938 hasConceptScore W2017394938C71240020 @default.
• W2017394938 hasIssue "36" @default.
• W2017394938 hasLocation W20173949381 @default.
• W2017394938 hasLocation W20173949382 @default.
• W2017394938 hasLocation W20173949383 @default.
• W2017394938 hasLocation W20173949384 @default.
• W2017394938 hasLocation W20173949385 @default.
• W2017394938 hasOpenAccess W2017394938 @default.
• W2017394938 hasPrimaryLocation W20173949381 @default.
• W2017394938 hasRelatedWork W2014935712 @default.
• W2017394938 hasRelatedWork W2031037667 @default.
• W2017394938 hasRelatedWork W2041274189 @default.
• W2017394938 hasRelatedWork W2050749384 @default.
• W2017394938 hasRelatedWork W2053220500 @default.
• W2017394938 hasRelatedWork W2097963130 @default.

• next