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- W2017395008 abstract "Selective androgen receptor modulators (SARMS) bind to the androgen receptor and demonstrate anabolic activity in a variety of tissues; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents are able to induce bone and muscle growth, as well as shrinking the prostate. The potential of SARMS is to maximise the positive attributes of steroidal androgens as well as minimising negative effects, thus providing therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, end-stage renal disease, osteoporosis, frailty and hypogonadism. This review summarises androgen physiolology, the current status of the R&D of SARMS and potential therapeutic indications for this emerging class of drugs." @default.
- W2017395008 created "2016-06-24" @default.
- W2017395008 creator A5002243266 @default.
- W2017395008 creator A5067659573 @default.
- W2017395008 creator A5069808741 @default.
- W2017395008 date "2006-03-21" @default.
- W2017395008 modified "2023-09-25" @default.
- W2017395008 title "Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery" @default.
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- W2017395008 doi "https://doi.org/10.1517/13543784.15.4.377" @default.
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