FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017397568> ?p ?o ?g. }

• W2017397568 endingPage "2147" @default.
• W2017397568 startingPage "2141" @default.
• W2017397568 abstract "Levosimendan was shown to increase calcium sensitivity by a novel mechanism and to inhibit phosphodiesterase III activity in animal myocardium.We investigated the influence of levosimendan on isometric contractions and calcium transients (aequorin method) in muscle strips from human hearts with end-stage failing dilated or ischemic cardiomyopathy (n=27). Data were compared with the effects of the phosphodiesterase inhibitor milrinone (n=9). The average maximum increase in twitch tension was 47+/-14% (range, 6% to 150%) at a levosimendan concentration of 0. 8+/-0.3 micromol/L (P<0.01). This was associated with significant increases in maximum rates of tension rise and fall and decreases in times to peak tension, to 50% relaxation, and to 95% relaxation. In aequorin-loaded muscles, levosimendan 10(-6) mol/L increased average tension by 50% (P<0.02), associated with a nonsignificant increase in aequorin light (16%). With milrinone 10(-5) mol/L, average tension increased by 58% and aequorin light by 49% (P<0.05). In those muscle strips with pronounced inotropic effects (>50% increase in tension), there was a comparable and pronounced increase in aequorin light with both agents. However, in muscle strips with weak inotropic responses (<50% increase in tension), the increase in light was significantly higher with milrinone than with levosimendan.Levosimendan has inotropic and lusitropic actions in failing human myocardium. Comparison with the phosphodiesterase inhibitor milrinone indicates that in case of pronounced inotropic stimulation, the modes of action of the two agents may be similar (phosphodiesterase inhibition), whereas small inotropic effects of levosimendan may result predominantly from calcium sensitization." @default.
• W2017397568 created "2016-06-24" @default.
• W2017397568 creator A5004362368 @default.
• W2017397568 creator A5007118900 @default.
• W2017397568 creator A5009905903 @default.
• W2017397568 creator A5041301910 @default.
• W2017397568 creator A5079834785 @default.
• W2017397568 creator A5088938475 @default.
• W2017397568 date "1998-11-17" @default.
• W2017397568 modified "2023-10-14" @default.
• W2017397568 title "Influence of the Novel Inotropic Agent Levosimendan on Isometric Tension and Calcium Cycling in Failing Human Myocardium" @default.
• W2017397568 cites W1556535974 @default.
• W2017397568 cites W1987376468 @default.
• W2017397568 cites W1992993596 @default.
• W2017397568 cites W1996917769 @default.
• W2017397568 cites W2000876750 @default.
• W2017397568 cites W2027298594 @default.
• W2017397568 cites W2033392308 @default.
• W2017397568 cites W2034897679 @default.
• W2017397568 cites W2076043526 @default.
• W2017397568 cites W2157973908 @default.
• W2017397568 cites W2319534362 @default.
• W2017397568 cites W2336310974 @default.
• W2017397568 cites W2585382523 @default.
• W2017397568 cites W4241770093 @default.
• W2017397568 cites W4245244523 @default.
• W2017397568 doi "https://doi.org/10.1161/01.cir.98.20.2141" @default.
• W2017397568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9815868" @default.
• W2017397568 hasPublicationYear "1998" @default.
• W2017397568 type Work @default.
• W2017397568 sameAs 2017397568 @default.
• W2017397568 citedByCount "276" @default.
• W2017397568 countsByYear W20173975682012 @default.
• W2017397568 countsByYear W20173975682013 @default.
• W2017397568 countsByYear W20173975682014 @default.
• W2017397568 countsByYear W20173975682015 @default.
• W2017397568 countsByYear W20173975682016 @default.
• W2017397568 countsByYear W20173975682017 @default.
• W2017397568 countsByYear W20173975682018 @default.
• W2017397568 countsByYear W20173975682019 @default.
• W2017397568 countsByYear W20173975682020 @default.
• W2017397568 countsByYear W20173975682021 @default.
• W2017397568 countsByYear W20173975682022 @default.
• W2017397568 countsByYear W20173975682023 @default.
• W2017397568 crossrefType "journal-article" @default.
• W2017397568 hasAuthorship W2017397568A5004362368 @default.
• W2017397568 hasAuthorship W2017397568A5007118900 @default.
• W2017397568 hasAuthorship W2017397568A5009905903 @default.
• W2017397568 hasAuthorship W2017397568A5041301910 @default.
• W2017397568 hasAuthorship W2017397568A5079834785 @default.
• W2017397568 hasAuthorship W2017397568A5088938475 @default.
• W2017397568 hasBestOaLocation W20173975681 @default.
• W2017397568 hasConcept C103486182 @default.
• W2017397568 hasConcept C126322002 @default.
• W2017397568 hasConcept C134018914 @default.
• W2017397568 hasConcept C155710745 @default.
• W2017397568 hasConcept C164705383 @default.
• W2017397568 hasConcept C181199279 @default.
• W2017397568 hasConcept C185592680 @default.
• W2017397568 hasConcept C2776645727 @default.
• W2017397568 hasConcept C2776766087 @default.
• W2017397568 hasConcept C2777335384 @default.
• W2017397568 hasConcept C519063684 @default.
• W2017397568 hasConcept C55493867 @default.
• W2017397568 hasConcept C62826618 @default.
• W2017397568 hasConcept C71924100 @default.
• W2017397568 hasConcept C80933277 @default.
• W2017397568 hasConceptScore W2017397568C103486182 @default.
• W2017397568 hasConceptScore W2017397568C126322002 @default.
• W2017397568 hasConceptScore W2017397568C134018914 @default.
• W2017397568 hasConceptScore W2017397568C155710745 @default.
• W2017397568 hasConceptScore W2017397568C164705383 @default.
• W2017397568 hasConceptScore W2017397568C181199279 @default.
• W2017397568 hasConceptScore W2017397568C185592680 @default.
• W2017397568 hasConceptScore W2017397568C2776645727 @default.
• W2017397568 hasConceptScore W2017397568C2776766087 @default.
• W2017397568 hasConceptScore W2017397568C2777335384 @default.
• W2017397568 hasConceptScore W2017397568C519063684 @default.
• W2017397568 hasConceptScore W2017397568C55493867 @default.
• W2017397568 hasConceptScore W2017397568C62826618 @default.
• W2017397568 hasConceptScore W2017397568C71924100 @default.
• W2017397568 hasConceptScore W2017397568C80933277 @default.
• W2017397568 hasIssue "20" @default.
• W2017397568 hasLocation W20173975681 @default.
• W2017397568 hasLocation W20173975682 @default.
• W2017397568 hasOpenAccess W2017397568 @default.
• W2017397568 hasPrimaryLocation W20173975681 @default.
• W2017397568 hasRelatedWork W1996127841 @default.
• W2017397568 hasRelatedWork W2091575018 @default.
• W2017397568 hasRelatedWork W2129350691 @default.
• W2017397568 hasRelatedWork W2252635017 @default.
• W2017397568 hasRelatedWork W2364251493 @default.
• W2017397568 hasRelatedWork W2809044574 @default.
• W2017397568 hasRelatedWork W2972612328 @default.
• W2017397568 hasRelatedWork W3032790161 @default.
• W2017397568 hasRelatedWork W4249643383 @default.
• W2017397568 hasRelatedWork W2519109828 @default.
• W2017397568 hasVolume "98" @default.

• next