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- W2017398413 abstract "Pseudomonas aeruginosa is a leading cause of infectious keratitis. Many ocular isolates of this bacterium invade corneal epithelial cells in vitro and in vivo. Antibiotic survival assays have shown that a complete core lipopolysaccharide is required for full epithelial invasion by P. aeruginosa. In this study, we show that P. aeruginosa mutants with defects in their lipopolysaccharide core and O antigen exhibited reduced viability after internalization by corneal epithelial cells. Restoration of lipopolysaccharide core and O antigen expression by complementation with the plasmid pLPS1 restored intracellular survival. P. aeruginosa strains with a complete lipopolysaccharide survived and replicated within the cells. The data suggest that lipopolysaccharide is involved in the intracellular survival and/or replication of P. aeruginosa, indicating an additional mechanism by which this important virulence factor may contribute to the pathogenesis of corneal infection." @default.
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- W2017398413 date "2002-12-01" @default.
- W2017398413 modified "2023-09-25" @default.
- W2017398413 title "Pseudomonas aeruginosa Strains with Lipopolysaccharide Defects Exhibit Reduced Intracellular Viability after Invasion of Corneal Epithelial Cells" @default.
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- W2017398413 doi "https://doi.org/10.1006/exer.2002.2072" @default.
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