FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017402871> ?p ?o ?g. }

• W2017402871 endingPage "184" @default.
• W2017402871 startingPage "173" @default.
• W2017402871 abstract "The integrity of neuroprotection is an important component against the development of cognitive disorders and AD. Within this context, DHEAS would seem to have some positive metabolic and endocrine effects to delay brain aging by recovering the impairment of neuroprotective growth factors. In the present study we measured by ELISA the secretion of insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and transforming growth factor-beta1 (TGFbeta1) in the supernatants of cultured circulating peripheral blood mononuclear cells (PBMC) from which natural killer cells (NK) were separated (PBMC-NK) (pg/ml/7.75x10(6) cells) in healthy subjects and in age-matched patients with mild to moderate AD. The growth factors were measured in spontaneous conditions and after stimulation with growth hormone (GH) 1 microg/ml (IGF-1), lipopolysaccharide (LPS) 1 microg/ml (VEGF) and glucose 10 microM (TGF(beta1). AD group demonstrated at baseline a severe reduction of IGF-1 (3.7+1.2 pg/ml after GH), VEGF (63+/-18 pg/ml spontaneous and 210+/-65 pg/ml after LPS) and TGF(beta1 (33+/-10 pg/ml spontaneous and 75+/-12 pg/ml after glucose) secretions compared to healthy elderly subjects (IGF-1, 9.5+/-2.8 pg/ml after GH, p<0.001; VEGF, 117+/-38 pg/ml spontaneous, p<0.001 and 690+/-120 pg/ml after LPS, p<0.001; and TGF(beta1, 73+/-21 pg/ml spontaneous, p<0.001 and 169+/-53 pg/ml after glucose, p<0.001). Significant positive correlations between IGF-1 and VEGF concentrations were found both in healthy subjects (r=0.87, p<0.001) and in AD subjects (r=0.87, p<0.001). The co-incubation of NK cells with DHEAS (10(6) M/ml/cells) significantly increase IGF-1, VEGF and TGF (beta1 production, reaching in AD group the normal concentrations found in healthy subjects (IGF-1, 7.9 + 2.4 pg/ml after GH; VEGF, 105+/-31 pg/ml spontaneous and 670+/-112 pg/ml after LPS; and TGFfbeta1, 68+/-18 pg/ml spontaneous and 155+/-48 pg/ml after glucose). These data suggested that DHEAS is able to increase the immunoendocrine production of neuroprotective growth factors, which is reduced in AD subjects, so suggesting a new approach in the treatment of dementia." @default.
• W2017402871 created "2016-06-24" @default.
• W2017402871 creator A5018911835 @default.
• W2017402871 creator A5028396140 @default.
• W2017402871 creator A5028941104 @default.
• W2017402871 creator A5036679971 @default.
• W2017402871 creator A5044126639 @default.
• W2017402871 creator A5046560252 @default.
• W2017402871 creator A5049373989 @default.
• W2017402871 creator A5049812298 @default.
• W2017402871 creator A5050054085 @default.
• W2017402871 creator A5061529085 @default.
• W2017402871 creator A5063393217 @default.
• W2017402871 creator A5065282885 @default.
• W2017402871 creator A5074382189 @default.
• W2017402871 creator A5080256055 @default.
• W2017402871 creator A5082744407 @default.
• W2017402871 creator A5090026505 @default.
• W2017402871 date "2009-01-01" @default.
• W2017402871 modified "2023-10-01" @default.
• W2017402871 title "GROWTH FACTORS DECREASE IN SUBJECTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE (AD): POTENTIAL CORRECTION WITH DEHYDROEPIANDROSTERONE-SULPHATE (DHEAS)" @default.
• W2017402871 cites W1471791345 @default.
• W2017402871 cites W1492360652 @default.
• W2017402871 cites W1586876258 @default.
• W2017402871 cites W174912705 @default.
• W2017402871 cites W1847168837 @default.
• W2017402871 cites W1870545401 @default.
• W2017402871 cites W1979505121 @default.
• W2017402871 cites W1992509442 @default.
• W2017402871 cites W1999356704 @default.
• W2017402871 cites W2001612609 @default.
• W2017402871 cites W2014868967 @default.
• W2017402871 cites W2015186493 @default.
• W2017402871 cites W2017985531 @default.
• W2017402871 cites W2037614169 @default.
• W2017402871 cites W2052644645 @default.
• W2017402871 cites W2056891806 @default.
• W2017402871 cites W2059981698 @default.
• W2017402871 cites W2083601732 @default.
• W2017402871 cites W2137554996 @default.
• W2017402871 cites W2150364650 @default.
• W2017402871 cites W2165092386 @default.
• W2017402871 cites W2168897511 @default.
• W2017402871 cites W4252905120 @default.
• W2017402871 doi "https://doi.org/10.1016/j.archger.2009.09.027" @default.
• W2017402871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19836631" @default.
• W2017402871 hasPublicationYear "2009" @default.
• W2017402871 type Work @default.
• W2017402871 sameAs 2017402871 @default.
• W2017402871 citedByCount "31" @default.
• W2017402871 countsByYear W20174028712012 @default.
• W2017402871 countsByYear W20174028712013 @default.
• W2017402871 countsByYear W20174028712014 @default.
• W2017402871 countsByYear W20174028712015 @default.
• W2017402871 countsByYear W20174028712016 @default.
• W2017402871 countsByYear W20174028712018 @default.
• W2017402871 countsByYear W20174028712019 @default.
• W2017402871 countsByYear W20174028712020 @default.
• W2017402871 countsByYear W20174028712021 @default.
• W2017402871 countsByYear W20174028712023 @default.
• W2017402871 crossrefType "journal-article" @default.
• W2017402871 hasAuthorship W2017402871A5018911835 @default.
• W2017402871 hasAuthorship W2017402871A5028396140 @default.
• W2017402871 hasAuthorship W2017402871A5028941104 @default.
• W2017402871 hasAuthorship W2017402871A5036679971 @default.
• W2017402871 hasAuthorship W2017402871A5044126639 @default.
• W2017402871 hasAuthorship W2017402871A5046560252 @default.
• W2017402871 hasAuthorship W2017402871A5049373989 @default.
• W2017402871 hasAuthorship W2017402871A5049812298 @default.
• W2017402871 hasAuthorship W2017402871A5050054085 @default.
• W2017402871 hasAuthorship W2017402871A5061529085 @default.
• W2017402871 hasAuthorship W2017402871A5063393217 @default.
• W2017402871 hasAuthorship W2017402871A5065282885 @default.
• W2017402871 hasAuthorship W2017402871A5074382189 @default.
• W2017402871 hasAuthorship W2017402871A5080256055 @default.
• W2017402871 hasAuthorship W2017402871A5082744407 @default.
• W2017402871 hasAuthorship W2017402871A5090026505 @default.
• W2017402871 hasConcept C118131993 @default.
• W2017402871 hasConcept C126322002 @default.
• W2017402871 hasConcept C134018914 @default.
• W2017402871 hasConcept C137061746 @default.
• W2017402871 hasConcept C151730666 @default.
• W2017402871 hasConcept C167734588 @default.
• W2017402871 hasConcept C170493617 @default.
• W2017402871 hasConcept C185592680 @default.
• W2017402871 hasConcept C202751555 @default.
• W2017402871 hasConcept C24998067 @default.
• W2017402871 hasConcept C2775960820 @default.
• W2017402871 hasConcept C2776992908 @default.
• W2017402871 hasConcept C2777025900 @default.
• W2017402871 hasConcept C2777911890 @default.
• W2017402871 hasConcept C2779343474 @default.
• W2017402871 hasConcept C2780689927 @default.
• W2017402871 hasConcept C55493867 @default.
• W2017402871 hasConcept C71315377 @default.
• W2017402871 hasConcept C71924100 @default.
• W2017402871 hasConcept C86803240 @default.
• W2017402871 hasConceptScore W2017402871C118131993 @default.

• next