Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017403318> ?p ?o ?g. }
- W2017403318 endingPage "150" @default.
- W2017403318 startingPage "147" @default.
- W2017403318 abstract "The expression of clock genes is altered in leukocytes from patients with Parkinson's disease (PD). However, the underlying mechanisms are unknown. To determine whether abnormal CpG methylation contributes to the dysregulated expression of these genes, the methylation status of the promoters of seven major human clock genes, PER1, PER2, CRY1, CRY2, Clock, NPAS2, and BMAL1, was examined using methylation-specific PCR (MSP) and sequencing in 206 PD patients and 181 healthy controls. This analysis revealed that most clock gene promoters were devoid of methylation. Methylation was only detectable in the CRY1 and NPAS2 promoters. Interestingly, the methylation frequency of the NPAS2 promoter was significantly decreased in PD patients. These results suggest that altered promoter methylation may contribute to the abnormal expression of clock genes in PD." @default.
- W2017403318 created "2016-06-24" @default.
- W2017403318 creator A5014027625 @default.
- W2017403318 creator A5014028115 @default.
- W2017403318 creator A5043734768 @default.
- W2017403318 creator A5050112775 @default.
- W2017403318 creator A5054622093 @default.
- W2017403318 creator A5077207763 @default.
- W2017403318 creator A5088041459 @default.
- W2017403318 creator A5088888083 @default.
- W2017403318 date "2012-01-01" @default.
- W2017403318 modified "2023-10-05" @default.
- W2017403318 title "Promoter methylation analysis of seven clock genes in Parkinson's disease" @default.
- W2017403318 cites W1969022395 @default.
- W2017403318 cites W1971040855 @default.
- W2017403318 cites W1973795177 @default.
- W2017403318 cites W1981218753 @default.
- W2017403318 cites W1981752009 @default.
- W2017403318 cites W1986869256 @default.
- W2017403318 cites W1992610922 @default.
- W2017403318 cites W1994354389 @default.
- W2017403318 cites W2003694686 @default.
- W2017403318 cites W2008560062 @default.
- W2017403318 cites W2022820516 @default.
- W2017403318 cites W2024450999 @default.
- W2017403318 cites W2046770376 @default.
- W2017403318 cites W2063701249 @default.
- W2017403318 cites W2075856383 @default.
- W2017403318 cites W2082904570 @default.
- W2017403318 cites W2085447354 @default.
- W2017403318 cites W2104290916 @default.
- W2017403318 cites W2136645014 @default.
- W2017403318 cites W2151487996 @default.
- W2017403318 cites W2168271199 @default.
- W2017403318 cites W3152331063 @default.
- W2017403318 doi "https://doi.org/10.1016/j.neulet.2011.12.007" @default.
- W2017403318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22193177" @default.
- W2017403318 hasPublicationYear "2012" @default.
- W2017403318 type Work @default.
- W2017403318 sameAs 2017403318 @default.
- W2017403318 citedByCount "59" @default.
- W2017403318 countsByYear W20174033182013 @default.
- W2017403318 countsByYear W20174033182014 @default.
- W2017403318 countsByYear W20174033182015 @default.
- W2017403318 countsByYear W20174033182016 @default.
- W2017403318 countsByYear W20174033182017 @default.
- W2017403318 countsByYear W20174033182018 @default.
- W2017403318 countsByYear W20174033182019 @default.
- W2017403318 countsByYear W20174033182020 @default.
- W2017403318 countsByYear W20174033182021 @default.
- W2017403318 countsByYear W20174033182022 @default.
- W2017403318 countsByYear W20174033182023 @default.
- W2017403318 crossrefType "journal-article" @default.
- W2017403318 hasAuthorship W2017403318A5014027625 @default.
- W2017403318 hasAuthorship W2017403318A5014028115 @default.
- W2017403318 hasAuthorship W2017403318A5043734768 @default.
- W2017403318 hasAuthorship W2017403318A5050112775 @default.
- W2017403318 hasAuthorship W2017403318A5054622093 @default.
- W2017403318 hasAuthorship W2017403318A5077207763 @default.
- W2017403318 hasAuthorship W2017403318A5088041459 @default.
- W2017403318 hasAuthorship W2017403318A5088888083 @default.
- W2017403318 hasConcept C101762097 @default.
- W2017403318 hasConcept C104317684 @default.
- W2017403318 hasConcept C140173407 @default.
- W2017403318 hasConcept C150194340 @default.
- W2017403318 hasConcept C153911025 @default.
- W2017403318 hasConcept C184738001 @default.
- W2017403318 hasConcept C190727270 @default.
- W2017403318 hasConcept C2779064383 @default.
- W2017403318 hasConcept C2780360009 @default.
- W2017403318 hasConcept C33288867 @default.
- W2017403318 hasConcept C54355233 @default.
- W2017403318 hasConcept C86803240 @default.
- W2017403318 hasConceptScore W2017403318C101762097 @default.
- W2017403318 hasConceptScore W2017403318C104317684 @default.
- W2017403318 hasConceptScore W2017403318C140173407 @default.
- W2017403318 hasConceptScore W2017403318C150194340 @default.
- W2017403318 hasConceptScore W2017403318C153911025 @default.
- W2017403318 hasConceptScore W2017403318C184738001 @default.
- W2017403318 hasConceptScore W2017403318C190727270 @default.
- W2017403318 hasConceptScore W2017403318C2779064383 @default.
- W2017403318 hasConceptScore W2017403318C2780360009 @default.
- W2017403318 hasConceptScore W2017403318C33288867 @default.
- W2017403318 hasConceptScore W2017403318C54355233 @default.
- W2017403318 hasConceptScore W2017403318C86803240 @default.
- W2017403318 hasIssue "2" @default.
- W2017403318 hasLocation W20174033181 @default.
- W2017403318 hasLocation W20174033182 @default.
- W2017403318 hasOpenAccess W2017403318 @default.
- W2017403318 hasPrimaryLocation W20174033181 @default.
- W2017403318 hasRelatedWork W1547949787 @default.
- W2017403318 hasRelatedWork W1971040855 @default.
- W2017403318 hasRelatedWork W1999023151 @default.
- W2017403318 hasRelatedWork W2002918346 @default.
- W2017403318 hasRelatedWork W2014240426 @default.
- W2017403318 hasRelatedWork W2017403318 @default.
- W2017403318 hasRelatedWork W2144473770 @default.
- W2017403318 hasRelatedWork W2782800916 @default.