FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017406246> ?p ?o ?g. }

• W2017406246 endingPage "530" @default.
• W2017406246 startingPage "525" @default.
• W2017406246 abstract "Recent reports have shown that the endoplasmic reticulum (ER) stress is relevant to the pathogenesis of Alzheimer disease. Following the amyloid cascade hypothesis, we therefore attempted to investigate the effects of ER stress on amyloid-β peptide (Aβ) generation. In this study, we found that ER stress altered the localization of amyloid precursor protein (APP) from late compartments to early compartments of the secretory pathway, and decreased the level of Aβ 40 and Aβ 42 release by β- and γ-cutting. Transient transfection with BiP/GRP78 also caused a shift of APP and a reduction in Aβ secretion. It was revealed that the ER stress response facilitated binding of BiP/GRP78 to APP, thereby causing it to be retained in the early compartments apart from a location suitable for the cleavages of Aβ. These findings suggest that induction of BiP/GRP78 during ER stress may be one of the regulatory mechanisms of Aβ generation." @default.
• W2017406246 created "2016-06-24" @default.
• W2017406246 creator A5006075587 @default.
• W2017406246 creator A5024953196 @default.
• W2017406246 creator A5025621056 @default.
• W2017406246 creator A5037218888 @default.
• W2017406246 creator A5041729199 @default.
• W2017406246 creator A5044171260 @default.
• W2017406246 creator A5045125241 @default.
• W2017406246 creator A5048571730 @default.
• W2017406246 creator A5053301510 @default.
• W2017406246 creator A5056375133 @default.
• W2017406246 creator A5057535269 @default.
• W2017406246 creator A5058016130 @default.
• W2017406246 creator A5058913082 @default.
• W2017406246 creator A5062670282 @default.
• W2017406246 creator A5069204628 @default.
• W2017406246 creator A5070265907 @default.
• W2017406246 creator A5072006202 @default.
• W2017406246 creator A5086522941 @default.
• W2017406246 date "2006-06-01" @default.
• W2017406246 modified "2023-10-07" @default.
• W2017406246 title "Altered localization of amyloid precursor protein under endoplasmic reticulum stress" @default.
• W2017406246 cites W1963530308 @default.
• W2017406246 cites W1964822121 @default.
• W2017406246 cites W1974470318 @default.
• W2017406246 cites W1991678120 @default.
• W2017406246 cites W1993772503 @default.
• W2017406246 cites W2005017513 @default.
• W2017406246 cites W2030182984 @default.
• W2017406246 cites W2034213169 @default.
• W2017406246 cites W2062688749 @default.
• W2017406246 cites W2068194010 @default.
• W2017406246 cites W2087662274 @default.
• W2017406246 cites W2096410114 @default.
• W2017406246 cites W2130082245 @default.
• W2017406246 cites W2130764195 @default.
• W2017406246 cites W2144859756 @default.
• W2017406246 doi "https://doi.org/10.1016/j.bbrc.2006.03.173" @default.
• W2017406246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16630560" @default.
• W2017406246 hasPublicationYear "2006" @default.
• W2017406246 type Work @default.
• W2017406246 sameAs 2017406246 @default.
• W2017406246 citedByCount "54" @default.
• W2017406246 countsByYear W20174062462012 @default.
• W2017406246 countsByYear W20174062462013 @default.
• W2017406246 countsByYear W20174062462014 @default.
• W2017406246 countsByYear W20174062462015 @default.
• W2017406246 countsByYear W20174062462016 @default.
• W2017406246 countsByYear W20174062462017 @default.
• W2017406246 countsByYear W20174062462018 @default.
• W2017406246 countsByYear W20174062462020 @default.
• W2017406246 countsByYear W20174062462021 @default.
• W2017406246 countsByYear W20174062462022 @default.
• W2017406246 countsByYear W20174062462023 @default.
• W2017406246 crossrefType "journal-article" @default.
• W2017406246 hasAuthorship W2017406246A5006075587 @default.
• W2017406246 hasAuthorship W2017406246A5024953196 @default.
• W2017406246 hasAuthorship W2017406246A5025621056 @default.
• W2017406246 hasAuthorship W2017406246A5037218888 @default.
• W2017406246 hasAuthorship W2017406246A5041729199 @default.
• W2017406246 hasAuthorship W2017406246A5044171260 @default.
• W2017406246 hasAuthorship W2017406246A5045125241 @default.
• W2017406246 hasAuthorship W2017406246A5048571730 @default.
• W2017406246 hasAuthorship W2017406246A5053301510 @default.
• W2017406246 hasAuthorship W2017406246A5056375133 @default.
• W2017406246 hasAuthorship W2017406246A5057535269 @default.
• W2017406246 hasAuthorship W2017406246A5058016130 @default.
• W2017406246 hasAuthorship W2017406246A5058913082 @default.
• W2017406246 hasAuthorship W2017406246A5062670282 @default.
• W2017406246 hasAuthorship W2017406246A5069204628 @default.
• W2017406246 hasAuthorship W2017406246A5070265907 @default.
• W2017406246 hasAuthorship W2017406246A5072006202 @default.
• W2017406246 hasAuthorship W2017406246A5086522941 @default.
• W2017406246 hasConcept C104317684 @default.
• W2017406246 hasConcept C119062480 @default.
• W2017406246 hasConcept C126322002 @default.
• W2017406246 hasConcept C139447449 @default.
• W2017406246 hasConcept C158617107 @default.
• W2017406246 hasConcept C177907266 @default.
• W2017406246 hasConcept C179104552 @default.
• W2017406246 hasConcept C185592680 @default.
• W2017406246 hasConcept C203014093 @default.
• W2017406246 hasConcept C2777633098 @default.
• W2017406246 hasConcept C2779134260 @default.
• W2017406246 hasConcept C2780942790 @default.
• W2017406246 hasConcept C31705614 @default.
• W2017406246 hasConcept C49039625 @default.
• W2017406246 hasConcept C502032728 @default.
• W2017406246 hasConcept C54009773 @default.
• W2017406246 hasConcept C55493867 @default.
• W2017406246 hasConcept C6492254 @default.
• W2017406246 hasConcept C71924100 @default.
• W2017406246 hasConcept C86803240 @default.
• W2017406246 hasConcept C95444343 @default.
• W2017406246 hasConceptScore W2017406246C104317684 @default.
• W2017406246 hasConceptScore W2017406246C119062480 @default.
• W2017406246 hasConceptScore W2017406246C126322002 @default.

• next