FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017407544> ?p ?o ?g. }

• W2017407544 endingPage "780" @default.
• W2017407544 startingPage "775" @default.
• W2017407544 abstract "Liposomes containing cholesterol (Chol) have long been used as an important membrane system for modeling the complex interactions of Chol with adjacent phospholipids or other lipids in a membrane environment. In this study we utilize a probe composed of QS-21, a saponin molecule that recognizes liposomal Chol and causes hemolysis of erythrocytes. The interaction of QS-21 with liposomal Chol results in a stable formulation which, after injection into the tissues of an animal, lacks toxic effects of QS-21 on neighboring cells that contain Chol, such as erythrocytes. Here we have used liposomes containing different saturated phospholipid fatty acyl groups and Chol, with or without monophosphoryl lipid A (MPLA), as model membranes. QS-21 is then employed as a probe to study the interactions of liposomal lipids on the visibility of membrane Chol. We demonstrate that changes either in the mole fraction of Chol in liposomes, or with different chain lengths of phospholipid fatty acyl groups, can have a substantial impact on the detection of Chol by the QS-21. We further show that liposomal MPLA can partially inhibit detection of the liposomal Chol by QS-21. The Limulus amebocyte lysate assay is used for binding to and detection of MPLA. Previous work has demonstrated that sequestration of MPLA into the liposomal lipid bilayer can block detection by the Limulus assay, but the binding site on the MPLA to which the Limulus protein binds is unknown. Changes in liposomal Chol concentration and phospholipid fatty acyl chain length influenced the detection of the liposome-embedded MPLA." @default.
• W2017407544 created "2016-06-24" @default.
• W2017407544 creator A5007536314 @default.
• W2017407544 creator A5019474861 @default.
• W2017407544 creator A5076380897 @default.
• W2017407544 date "2015-03-01" @default.
• W2017407544 modified "2023-09-26" @default.
• W2017407544 title "Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate" @default.
• W2017407544 cites W110642283 @default.
• W2017407544 cites W1513161963 @default.
• W2017407544 cites W1549874587 @default.
• W2017407544 cites W1845134086 @default.
• W2017407544 cites W1922307675 @default.
• W2017407544 cites W1969593838 @default.
• W2017407544 cites W1971188484 @default.
• W2017407544 cites W1974164851 @default.
• W2017407544 cites W1977182743 @default.
• W2017407544 cites W1978046661 @default.
• W2017407544 cites W1981776025 @default.
• W2017407544 cites W1982943247 @default.
• W2017407544 cites W1987697559 @default.
• W2017407544 cites W1995710115 @default.
• W2017407544 cites W1997041526 @default.
• W2017407544 cites W1999906821 @default.
• W2017407544 cites W2001052983 @default.
• W2017407544 cites W2001355446 @default.
• W2017407544 cites W2010265988 @default.
• W2017407544 cites W2011093544 @default.
• W2017407544 cites W2016081626 @default.
• W2017407544 cites W2017484470 @default.
• W2017407544 cites W2027821009 @default.
• W2017407544 cites W2033575799 @default.
• W2017407544 cites W2036735222 @default.
• W2017407544 cites W2039518452 @default.
• W2017407544 cites W2041304269 @default.
• W2017407544 cites W2043483779 @default.
• W2017407544 cites W2043991964 @default.
• W2017407544 cites W2047788323 @default.
• W2017407544 cites W2049705078 @default.
• W2017407544 cites W2050472254 @default.
• W2017407544 cites W2055017188 @default.
• W2017407544 cites W2061417691 @default.
• W2017407544 cites W2073883965 @default.
• W2017407544 cites W2074880885 @default.
• W2017407544 cites W2078791944 @default.
• W2017407544 cites W2080425806 @default.
• W2017407544 cites W2092897239 @default.
• W2017407544 cites W2097766975 @default.
• W2017407544 cites W2102130081 @default.
• W2017407544 cites W2108063531 @default.
• W2017407544 cites W2121936687 @default.
• W2017407544 cites W2132741431 @default.
• W2017407544 cites W2132915849 @default.
• W2017407544 cites W2133589116 @default.
• W2017407544 cites W2134403927 @default.
• W2017407544 cites W2136558879 @default.
• W2017407544 cites W2138607365 @default.
• W2017407544 cites W2149883005 @default.
• W2017407544 cites W2154167687 @default.
• W2017407544 cites W2156612053 @default.
• W2017407544 cites W2170885541 @default.
• W2017407544 cites W4233264093 @default.
• W2017407544 doi "https://doi.org/10.1016/j.bbamem.2014.12.005" @default.
• W2017407544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25511587" @default.
• W2017407544 hasPublicationYear "2015" @default.
• W2017407544 type Work @default.
• W2017407544 sameAs 2017407544 @default.
• W2017407544 citedByCount "44" @default.
• W2017407544 countsByYear W20174075442015 @default.
• W2017407544 countsByYear W20174075442016 @default.
• W2017407544 countsByYear W20174075442017 @default.
• W2017407544 countsByYear W20174075442018 @default.
• W2017407544 countsByYear W20174075442019 @default.
• W2017407544 countsByYear W20174075442020 @default.
• W2017407544 countsByYear W20174075442021 @default.
• W2017407544 countsByYear W20174075442022 @default.
• W2017407544 countsByYear W20174075442023 @default.
• W2017407544 crossrefType "journal-article" @default.
• W2017407544 hasAuthorship W2017407544A5007536314 @default.
• W2017407544 hasAuthorship W2017407544A5019474861 @default.
• W2017407544 hasAuthorship W2017407544A5076380897 @default.
• W2017407544 hasConcept C151730666 @default.
• W2017407544 hasConcept C185154212 @default.
• W2017407544 hasConcept C185592680 @default.
• W2017407544 hasConcept C203014093 @default.
• W2017407544 hasConcept C2776040547 @default.
• W2017407544 hasConcept C2776487282 @default.
• W2017407544 hasConcept C2778754761 @default.
• W2017407544 hasConcept C2778918659 @default.
• W2017407544 hasConcept C39944091 @default.
• W2017407544 hasConcept C41625074 @default.
• W2017407544 hasConcept C55493867 @default.
• W2017407544 hasConcept C57409179 @default.
• W2017407544 hasConcept C86803240 @default.
• W2017407544 hasConceptScore W2017407544C151730666 @default.
• W2017407544 hasConceptScore W2017407544C185154212 @default.
• W2017407544 hasConceptScore W2017407544C185592680 @default.
• W2017407544 hasConceptScore W2017407544C203014093 @default.

• next