FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017409563> ?p ?o ?g. }

• W2017409563 endingPage "4342" @default.
• W2017409563 startingPage "4330" @default.
• W2017409563 abstract "Viscoelastic changes of the lamellipodial actin cytoskeleton are a fundamental element of cell motility. Thus, the correlation between the local viscoelastic properties of the lamellipodium (including the transitional region to the cell body) and the speed of lamellipodial extension is studied for normal and malignantly transformed fibroblasts. Using our atomic force microscopy-based microrheology technique, we found different mechanical properties between the lamellipodia of malignantly transformed fibroblasts (H-ras transformed and SV-T2 fibroblasts) and normal fibroblasts (BALB 3T3 fibroblasts). The average elastic constants, K, in the leading edge of SV-T2 fibroblasts (0.48 ± 0.51 kPa) and of H-ras transformed fibroblasts (0.42 ± 0.35 kPa) are significantly lower than that of BALB 3T3 fibroblasts (1.01 ± 0.40 kPa). The analysis of time-lapse phase contrast images shows that the decrease in the elastic constant, K, for malignantly transformed fibroblasts is correlated with the enhanced motility of the lamellipodium. The measured mean speeds are 6.1 ± 4.5 μ m/h for BALB 3T3 fibroblasts, 13.1 ± 5.2 μm/h for SV-T2 fibroblasts, and 26.2 ± 11.5 μm/h for H-ras fibroblasts. Furthermore, the elastic constant, K, increases toward the cell body in many instances which coincide with an increase in actin filament density toward the cell body. The correlation between the enhanced motility and the decrease in viscoelastic moduli supports the Elastic Brownian Ratchet model for driving lamellipodia extension." @default.
• W2017409563 created "2016-06-24" @default.
• W2017409563 creator A5015712012 @default.
• W2017409563 creator A5017365819 @default.
• W2017409563 creator A5018134091 @default.
• W2017409563 creator A5026249666 @default.
• W2017409563 creator A5073866517 @default.
• W2017409563 date "2005-12-01" @default.
• W2017409563 modified "2023-10-18" @default.
• W2017409563 title "Cell Motility and Local Viscoelasticity of Fibroblasts" @default.
• W2017409563 cites W1963969404 @default.
• W2017409563 cites W1970058540 @default.
• W2017409563 cites W1972152068 @default.
• W2017409563 cites W1972516366 @default.
• W2017409563 cites W1973334921 @default.
• W2017409563 cites W1973420649 @default.
• W2017409563 cites W1974262428 @default.
• W2017409563 cites W1977458589 @default.
• W2017409563 cites W1978525637 @default.
• W2017409563 cites W1991971871 @default.
• W2017409563 cites W2001236747 @default.
• W2017409563 cites W2002208582 @default.
• W2017409563 cites W2002995722 @default.
• W2017409563 cites W2005084201 @default.
• W2017409563 cites W2006073003 @default.
• W2017409563 cites W2008922313 @default.
• W2017409563 cites W2009623058 @default.
• W2017409563 cites W2014348407 @default.
• W2017409563 cites W2015458324 @default.
• W2017409563 cites W2020011192 @default.
• W2017409563 cites W2026067570 @default.
• W2017409563 cites W2027052987 @default.
• W2017409563 cites W2030463167 @default.
• W2017409563 cites W2032266902 @default.
• W2017409563 cites W2038530502 @default.
• W2017409563 cites W2039861570 @default.
• W2017409563 cites W2051165421 @default.
• W2017409563 cites W2063411991 @default.
• W2017409563 cites W2068857189 @default.
• W2017409563 cites W2079175432 @default.
• W2017409563 cites W2079944376 @default.
• W2017409563 cites W2085313371 @default.
• W2017409563 cites W2091587708 @default.
• W2017409563 cites W2092994838 @default.
• W2017409563 cites W2095587920 @default.
• W2017409563 cites W2100032334 @default.
• W2017409563 cites W2100041293 @default.
• W2017409563 cites W2100324155 @default.
• W2017409563 cites W2105789974 @default.
• W2017409563 cites W2110478336 @default.
• W2017409563 cites W2110931675 @default.
• W2017409563 cites W2112360585 @default.
• W2017409563 cites W2112989848 @default.
• W2017409563 cites W2113486744 @default.
• W2017409563 cites W2122782850 @default.
• W2017409563 cites W2147599162 @default.
• W2017409563 cites W2168223802 @default.
• W2017409563 cites W2169549062 @default.
• W2017409563 cites W2170080899 @default.
• W2017409563 cites W2409772426 @default.
• W2017409563 cites W2416633187 @default.
• W2017409563 cites W2461980944 @default.
• W2017409563 cites W70680176 @default.
• W2017409563 doi "https://doi.org/10.1529/biophysj.104.053462" @default.
• W2017409563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1366997" @default.
• W2017409563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16199496" @default.
• W2017409563 hasPublicationYear "2005" @default.
• W2017409563 type Work @default.
• W2017409563 sameAs 2017409563 @default.
• W2017409563 citedByCount "133" @default.
• W2017409563 countsByYear W20174095632012 @default.
• W2017409563 countsByYear W20174095632013 @default.
• W2017409563 countsByYear W20174095632014 @default.
• W2017409563 countsByYear W20174095632015 @default.
• W2017409563 countsByYear W20174095632016 @default.
• W2017409563 countsByYear W20174095632017 @default.
• W2017409563 countsByYear W20174095632018 @default.
• W2017409563 countsByYear W20174095632019 @default.
• W2017409563 countsByYear W20174095632020 @default.
• W2017409563 countsByYear W20174095632021 @default.
• W2017409563 countsByYear W20174095632022 @default.
• W2017409563 countsByYear W20174095632023 @default.
• W2017409563 crossrefType "journal-article" @default.
• W2017409563 hasAuthorship W2017409563A5015712012 @default.
• W2017409563 hasAuthorship W2017409563A5017365819 @default.
• W2017409563 hasAuthorship W2017409563A5018134091 @default.
• W2017409563 hasAuthorship W2017409563A5026249666 @default.
• W2017409563 hasAuthorship W2017409563A5073866517 @default.
• W2017409563 hasBestOaLocation W20174095631 @default.
• W2017409563 hasConcept C104317684 @default.
• W2017409563 hasConcept C109185818 @default.
• W2017409563 hasConcept C12554922 @default.
• W2017409563 hasConcept C125705527 @default.
• W2017409563 hasConcept C142669718 @default.
• W2017409563 hasConcept C1491633281 @default.
• W2017409563 hasConcept C159985019 @default.
• W2017409563 hasConcept C185592680 @default.
• W2017409563 hasConcept C186541917 @default.

• next