Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017411379> ?p ?o ?g. }
- W2017411379 endingPage "4406" @default.
- W2017411379 startingPage "4400" @default.
- W2017411379 abstract "Abstract STAT3 regulates cell growth by up-regulating downstream targets, such as Myc. The frequency of phosphorylated STAT3 (pSTAT3) and Myc expression and their prognostic relevance is unknown within diffuse large B-cell lymphoma (DLBCL) germinal center B-cell (GCB) and non-GCB subtypes. pSTAT3 and Myc were studied by immunohistochemistry (IHC) on tumors from 40 DLBCL patients uniformly treated on a clinical trial of epratuzumab/rituximab-CHOP. A total of 35% of cases were pSTAT3-positive, and pSTAT3 positivity was more frequent in the non-GCB (P = .06) type but did not correlate with event-free survival (EFS). Myc expression was observed in 50% of cases and was more frequent in non-GCB type (P = .07). Myc-positive cases had inferior EFS in all patients, including the GCB and pSTAT3-positive cases, were more likely to express Myc (P = .06). Myc translocations involving the major breakpoint regions were found in 10% (3 of 29) of cases, and all 3 cases were GCB and had an inferior EFS (P = .09). pSTAT3, but not Myc expression, was correlated with elevated pretreatment serum cytokines, such as IL-10 (P = .05), G-CSF (P = .03), and TNF-α (P = .04). pSTAT3 IHC in DLBCL tumors has the potential to identify patients for STAT3 pathway–directed therapy; Myc IHC is a potential marker for inferior EFS in GCB patients." @default.
- W2017411379 created "2016-06-24" @default.
- W2017411379 creator A5004152557 @default.
- W2017411379 creator A5013059066 @default.
- W2017411379 creator A5023219857 @default.
- W2017411379 creator A5024505450 @default.
- W2017411379 creator A5028628268 @default.
- W2017411379 creator A5035642271 @default.
- W2017411379 creator A5039253243 @default.
- W2017411379 creator A5048644166 @default.
- W2017411379 creator A5059417970 @default.
- W2017411379 date "2012-11-22" @default.
- W2017411379 modified "2023-09-27" @default.
- W2017411379 title "Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP" @default.
- W2017411379 cites W1821858011 @default.
- W2017411379 cites W1976564639 @default.
- W2017411379 cites W1977824829 @default.
- W2017411379 cites W1985361684 @default.
- W2017411379 cites W1988703453 @default.
- W2017411379 cites W1994719395 @default.
- W2017411379 cites W2000487932 @default.
- W2017411379 cites W2001923666 @default.
- W2017411379 cites W2007440333 @default.
- W2017411379 cites W2011937137 @default.
- W2017411379 cites W2028441957 @default.
- W2017411379 cites W2032972450 @default.
- W2017411379 cites W2038023916 @default.
- W2017411379 cites W2040893174 @default.
- W2017411379 cites W2042794591 @default.
- W2017411379 cites W2043439081 @default.
- W2017411379 cites W2049548558 @default.
- W2017411379 cites W2057239580 @default.
- W2017411379 cites W2058015212 @default.
- W2017411379 cites W2062424910 @default.
- W2017411379 cites W2067637255 @default.
- W2017411379 cites W2070217465 @default.
- W2017411379 cites W2074356752 @default.
- W2017411379 cites W2089805238 @default.
- W2017411379 cites W2111716055 @default.
- W2017411379 cites W2118310862 @default.
- W2017411379 cites W2139204503 @default.
- W2017411379 cites W2140485109 @default.
- W2017411379 cites W2153665789 @default.
- W2017411379 cites W2158267770 @default.
- W2017411379 cites W2163990748 @default.
- W2017411379 cites W2166436914 @default.
- W2017411379 cites W2168438686 @default.
- W2017411379 cites W4293241248 @default.
- W2017411379 doi "https://doi.org/10.1182/blood-2012-05-428466" @default.
- W2017411379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3507146" @default.
- W2017411379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23018644" @default.
- W2017411379 hasPublicationYear "2012" @default.
- W2017411379 type Work @default.
- W2017411379 sameAs 2017411379 @default.
- W2017411379 citedByCount "53" @default.
- W2017411379 countsByYear W20174113792013 @default.
- W2017411379 countsByYear W20174113792014 @default.
- W2017411379 countsByYear W20174113792015 @default.
- W2017411379 countsByYear W20174113792016 @default.
- W2017411379 countsByYear W20174113792017 @default.
- W2017411379 countsByYear W20174113792018 @default.
- W2017411379 countsByYear W20174113792019 @default.
- W2017411379 countsByYear W20174113792020 @default.
- W2017411379 countsByYear W20174113792021 @default.
- W2017411379 countsByYear W20174113792022 @default.
- W2017411379 countsByYear W20174113792023 @default.
- W2017411379 crossrefType "journal-article" @default.
- W2017411379 hasAuthorship W2017411379A5004152557 @default.
- W2017411379 hasAuthorship W2017411379A5013059066 @default.
- W2017411379 hasAuthorship W2017411379A5023219857 @default.
- W2017411379 hasAuthorship W2017411379A5024505450 @default.
- W2017411379 hasAuthorship W2017411379A5028628268 @default.
- W2017411379 hasAuthorship W2017411379A5035642271 @default.
- W2017411379 hasAuthorship W2017411379A5039253243 @default.
- W2017411379 hasAuthorship W2017411379A5048644166 @default.
- W2017411379 hasAuthorship W2017411379A5059417970 @default.
- W2017411379 hasBestOaLocation W20174113791 @default.
- W2017411379 hasConcept C104317684 @default.
- W2017411379 hasConcept C126322002 @default.
- W2017411379 hasConcept C138626823 @default.
- W2017411379 hasConcept C142724271 @default.
- W2017411379 hasConcept C159654299 @default.
- W2017411379 hasConcept C203014093 @default.
- W2017411379 hasConcept C204232928 @default.
- W2017411379 hasConcept C2778453870 @default.
- W2017411379 hasConcept C2778559949 @default.
- W2017411379 hasConcept C2778923194 @default.
- W2017411379 hasConcept C2779338263 @default.
- W2017411379 hasConcept C2779725641 @default.
- W2017411379 hasConcept C2780653079 @default.
- W2017411379 hasConcept C502942594 @default.
- W2017411379 hasConcept C55493867 @default.
- W2017411379 hasConcept C62478195 @default.
- W2017411379 hasConcept C71924100 @default.
- W2017411379 hasConcept C86803240 @default.
- W2017411379 hasConcept C96926380 @default.
- W2017411379 hasConceptScore W2017411379C104317684 @default.
- W2017411379 hasConceptScore W2017411379C126322002 @default.