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• W2017423022 abstract "RationaleStudies show fewer atopic characteristics in children raised on farms, possibly because greater exposure to microorganisms influences immune development. Thymic stromal lymphopoetin (TSLP) and interleukin-33 (IL-33) are secreted by epithelial cells and promote atopy development. We hypothesized that TSLP and IL-33 levels in children from farm environments would be lower than levels in non-farm counterparts.MethodsNine children raised on farms were selected from the Childhood Origins of ASThma (COAST) database, a prospective birth cohort of 259 children. Levels of TSLP and IL-33 were measured by ELISA in plasma obtained at ages 2 and 4 years. These data were compared using a rank sum test to data from randomly-selected, age-matched children from the study with: 1) no atopy (no demonstrable allergic sensitization), 2) wheezing, 3) allergen sensitization, and 4) wheezing plus allergen sensitization.ResultsThere were no significant differences in IL-33 or TSLP among the 4 groups of non-farm children (p=0.462 & 0.629 respectively). At year 2, median IL-33 for the farm group was 37.6 pg/mL compared to 185 pg/mL for the non-farm group (p=0.055), and median TSLP was 12.9 pg/mL compared to 65.6 pg/mL (p=0.039). No significant difference existed among the groups for IL-33 (p=0.627) or TSLP (p=0.578) at year 4.ConclusionsIn the first two years of life, farm children had lower TSLP and IL-33 levels than non-farm children, regardless of the presence of atopic characteristics or wheeze. This suggests that early farm-related exposures may down regulate TSLP and IL-33 production by epithelial cells leading to a lower incidence of atopy. RationaleStudies show fewer atopic characteristics in children raised on farms, possibly because greater exposure to microorganisms influences immune development. Thymic stromal lymphopoetin (TSLP) and interleukin-33 (IL-33) are secreted by epithelial cells and promote atopy development. We hypothesized that TSLP and IL-33 levels in children from farm environments would be lower than levels in non-farm counterparts. Studies show fewer atopic characteristics in children raised on farms, possibly because greater exposure to microorganisms influences immune development. Thymic stromal lymphopoetin (TSLP) and interleukin-33 (IL-33) are secreted by epithelial cells and promote atopy development. We hypothesized that TSLP and IL-33 levels in children from farm environments would be lower than levels in non-farm counterparts. MethodsNine children raised on farms were selected from the Childhood Origins of ASThma (COAST) database, a prospective birth cohort of 259 children. Levels of TSLP and IL-33 were measured by ELISA in plasma obtained at ages 2 and 4 years. These data were compared using a rank sum test to data from randomly-selected, age-matched children from the study with: 1) no atopy (no demonstrable allergic sensitization), 2) wheezing, 3) allergen sensitization, and 4) wheezing plus allergen sensitization. Nine children raised on farms were selected from the Childhood Origins of ASThma (COAST) database, a prospective birth cohort of 259 children. Levels of TSLP and IL-33 were measured by ELISA in plasma obtained at ages 2 and 4 years. These data were compared using a rank sum test to data from randomly-selected, age-matched children from the study with: 1) no atopy (no demonstrable allergic sensitization), 2) wheezing, 3) allergen sensitization, and 4) wheezing plus allergen sensitization. ResultsThere were no significant differences in IL-33 or TSLP among the 4 groups of non-farm children (p=0.462 & 0.629 respectively). At year 2, median IL-33 for the farm group was 37.6 pg/mL compared to 185 pg/mL for the non-farm group (p=0.055), and median TSLP was 12.9 pg/mL compared to 65.6 pg/mL (p=0.039). No significant difference existed among the groups for IL-33 (p=0.627) or TSLP (p=0.578) at year 4. There were no significant differences in IL-33 or TSLP among the 4 groups of non-farm children (p=0.462 & 0.629 respectively). At year 2, median IL-33 for the farm group was 37.6 pg/mL compared to 185 pg/mL for the non-farm group (p=0.055), and median TSLP was 12.9 pg/mL compared to 65.6 pg/mL (p=0.039). No significant difference existed among the groups for IL-33 (p=0.627) or TSLP (p=0.578) at year 4. ConclusionsIn the first two years of life, farm children had lower TSLP and IL-33 levels than non-farm children, regardless of the presence of atopic characteristics or wheeze. This suggests that early farm-related exposures may down regulate TSLP and IL-33 production by epithelial cells leading to a lower incidence of atopy. In the first two years of life, farm children had lower TSLP and IL-33 levels than non-farm children, regardless of the presence of atopic characteristics or wheeze. This suggests that early farm-related exposures may down regulate TSLP and IL-33 production by epithelial cells leading to a lower incidence of atopy." @default.
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• W2017423022 title "Serum TSLP and IL-33 Levels are Lower in Young Children Raised on Farms" @default.
• W2017423022 doi "https://doi.org/10.1016/j.jaci.2011.12.304" @default.
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