Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017431068> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2017431068 endingPage "80" @default.
- W2017431068 startingPage "75" @default.
- W2017431068 abstract "Single intravenous doses of 10, 20, 40, and 80 mg and repeated once daily intravenous doses of 10 and 20 mg omeprazole induced a powerful and long lasting inhibition of pentagastrin stimulated gastric acid secretion (PAO) in healthy male volunteers. Single intravenous doses of 10, 20, 40, and 80 mg omeprazole inhibited PAO by 30% (p less than 0.01), 45% (p less than 0.01), 61% (p less than 0.01), and 80% (p less than 0.01), respectively when measured 1.5 h after dose, and by 20% (NS), 27% (NS), 36% (p less than 0.01) and 59% (p less than 0.01), respectively when measured 24 h after dose. Six days after repeated once daily intravenous doses of 10 and 20 mg omeprazole, PAO was inhibited by 63% (p less than 0.01) and 82% (p less than 0.01), respectively when measured 1.5 h after dose, and by 32% (p less than 0.01) and 43% (p less than 0.01), respectively when measured 24 h after dose. The inhibition of PAO by 10 mg administered intravenously as a single bolus injection was comparable with the inhibition by 20 mg as a single oral dose. Repeated once daily administration of 10 mg intravenously and 20 mg orally also resulted in comparable reductions in PAO. The reduction in PAO after repeated once daily oral administration of 20 mg was comparable with the effect of a single intravenous dose of 40 mg. Terminal half lives were short, but significantly (p less than 0.05) prolonged after a single intravenous injection of 80 mg. Repeated once daily intravenous administration of 10 and 20 mg did not result in prolongation of terminal half lives. It is concluded that intravenous administration of omeprazole causes a potent and long acting inhibition of pentagastrin stimulated gastric acid secretion in man. Its potency is augmented after repeated once daily administration." @default.
- W2017431068 created "2016-06-24" @default.
- W2017431068 creator A5006005139 @default.
- W2017431068 creator A5014264857 @default.
- W2017431068 creator A5016997548 @default.
- W2017431068 creator A5020953354 @default.
- W2017431068 creator A5022464609 @default.
- W2017431068 creator A5035380713 @default.
- W2017431068 creator A5064234349 @default.
- W2017431068 creator A5079248792 @default.
- W2017431068 date "1988-01-01" @default.
- W2017431068 modified "2023-10-16" @default.
- W2017431068 title "Effect of single and repeated intravenous doses of omeprazole on pentagastrin stimulated gastric acid secretion and pharmacokinetics in man." @default.
- W2017431068 cites W122184333 @default.
- W2017431068 cites W1983220895 @default.
- W2017431068 cites W1985499927 @default.
- W2017431068 cites W1996284297 @default.
- W2017431068 cites W2004105895 @default.
- W2017431068 cites W2017472773 @default.
- W2017431068 cites W2047644905 @default.
- W2017431068 cites W2084334012 @default.
- W2017431068 cites W2092090185 @default.
- W2017431068 cites W2095279377 @default.
- W2017431068 cites W2151461746 @default.
- W2017431068 cites W2168234648 @default.
- W2017431068 cites W2420688726 @default.
- W2017431068 cites W2801529539 @default.
- W2017431068 doi "https://doi.org/10.1136/gut.29.1.75" @default.
- W2017431068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1433269" @default.
- W2017431068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3343017" @default.
- W2017431068 hasPublicationYear "1988" @default.
- W2017431068 type Work @default.
- W2017431068 sameAs 2017431068 @default.
- W2017431068 citedByCount "50" @default.
- W2017431068 countsByYear W20174310682012 @default.
- W2017431068 countsByYear W20174310682014 @default.
- W2017431068 countsByYear W20174310682016 @default.
- W2017431068 countsByYear W20174310682017 @default.
- W2017431068 countsByYear W20174310682018 @default.
- W2017431068 crossrefType "journal-article" @default.
- W2017431068 hasAuthorship W2017431068A5006005139 @default.
- W2017431068 hasAuthorship W2017431068A5014264857 @default.
- W2017431068 hasAuthorship W2017431068A5016997548 @default.
- W2017431068 hasAuthorship W2017431068A5020953354 @default.
- W2017431068 hasAuthorship W2017431068A5022464609 @default.
- W2017431068 hasAuthorship W2017431068A5035380713 @default.
- W2017431068 hasAuthorship W2017431068A5064234349 @default.
- W2017431068 hasAuthorship W2017431068A5079248792 @default.
- W2017431068 hasBestOaLocation W20174310681 @default.
- W2017431068 hasConcept C112705442 @default.
- W2017431068 hasConcept C126322002 @default.
- W2017431068 hasConcept C2777498785 @default.
- W2017431068 hasConcept C2777504413 @default.
- W2017431068 hasConcept C2779377912 @default.
- W2017431068 hasConcept C2779422922 @default.
- W2017431068 hasConcept C3020190219 @default.
- W2017431068 hasConcept C43376680 @default.
- W2017431068 hasConcept C71924100 @default.
- W2017431068 hasConcept C79410662 @default.
- W2017431068 hasConcept C98274493 @default.
- W2017431068 hasConceptScore W2017431068C112705442 @default.
- W2017431068 hasConceptScore W2017431068C126322002 @default.
- W2017431068 hasConceptScore W2017431068C2777498785 @default.
- W2017431068 hasConceptScore W2017431068C2777504413 @default.
- W2017431068 hasConceptScore W2017431068C2779377912 @default.
- W2017431068 hasConceptScore W2017431068C2779422922 @default.
- W2017431068 hasConceptScore W2017431068C3020190219 @default.
- W2017431068 hasConceptScore W2017431068C43376680 @default.
- W2017431068 hasConceptScore W2017431068C71924100 @default.
- W2017431068 hasConceptScore W2017431068C79410662 @default.
- W2017431068 hasConceptScore W2017431068C98274493 @default.
- W2017431068 hasIssue "1" @default.
- W2017431068 hasLocation W20174310681 @default.
- W2017431068 hasLocation W20174310682 @default.
- W2017431068 hasLocation W20174310683 @default.
- W2017431068 hasLocation W20174310684 @default.
- W2017431068 hasOpenAccess W2017431068 @default.
- W2017431068 hasPrimaryLocation W20174310681 @default.
- W2017431068 hasRelatedWork W1966926851 @default.
- W2017431068 hasRelatedWork W1985762011 @default.
- W2017431068 hasRelatedWork W2017431068 @default.
- W2017431068 hasRelatedWork W2058668781 @default.
- W2017431068 hasRelatedWork W2093599881 @default.
- W2017431068 hasRelatedWork W2135601318 @default.
- W2017431068 hasRelatedWork W2168234648 @default.
- W2017431068 hasRelatedWork W2401992223 @default.
- W2017431068 hasRelatedWork W4377967821 @default.
- W2017431068 hasRelatedWork W44104988 @default.
- W2017431068 hasVolume "29" @default.
- W2017431068 isParatext "false" @default.
- W2017431068 isRetracted "false" @default.
- W2017431068 magId "2017431068" @default.
- W2017431068 workType "article" @default.