Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017431319> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2017431319 abstract "Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the apoptotic pathomechanism involving calprotectin and the CD95 receptor (CD95R, FasR) in TEN. The expression of these two molecules corresponds to calcium-dependent and calcium-independent processes, respectively. Biopsies were collected from blistering skin in 21 TEN patients and from clinically uninvolved skin in 16 of these patients. Immunohistochemistry was performed using specific antibodies directed to CD95R and calprotectin. Half (8/16) of the biopsy specimens taken from clinically uninvolved sites showed the expression of calprotectin throughout the epidermis or restricted to the suprabasal layers. In these samples, a strong CD95R immunoreactivity was often restricted to the basal layer (8/16). Calprotectin was present in all biopsies of bullous skin, especially in suprabasal layers (15/21) or throughout the epidermis (6/21). By contrast, the prominent expression of CD95R was confined almost exclusively to the basal layer (15/21), and more rarely throughout the epidermis (2/21), and it remained sometimes unexpressed (4/21). A clear-cut boundary was often present between the areas labeled by the two antibodies with exceptional overlap between them. The simultaneous expression of calprotectin and CD95R in TEN at distinct levels of the epidermis indicates that the pathomechanism leading to keratinocyte death does not belong to a single process in TEN. Their expression in clinically uninvolved skin suggests that these processes are early and widespread events in TEN." @default.
- W2017431319 created "2016-06-24" @default.
- W2017431319 creator A5035465119 @default.
- W2017431319 creator A5038961462 @default.
- W2017431319 date "2002-08-01" @default.
- W2017431319 modified "2023-10-10" @default.
- W2017431319 title "Keratinocyte injury in drug-induced toxic epidermal necrolysis: Simultaneous but distinct topographic expression of CD95R and calprotectin" @default.
- W2017431319 doi "https://doi.org/10.3892/ijmm.10.2.145" @default.
- W2017431319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12119549" @default.
- W2017431319 hasPublicationYear "2002" @default.
- W2017431319 type Work @default.
- W2017431319 sameAs 2017431319 @default.
- W2017431319 citedByCount "14" @default.
- W2017431319 countsByYear W20174313192014 @default.
- W2017431319 countsByYear W20174313192019 @default.
- W2017431319 countsByYear W20174313192023 @default.
- W2017431319 crossrefType "journal-article" @default.
- W2017431319 hasAuthorship W2017431319A5035465119 @default.
- W2017431319 hasAuthorship W2017431319A5038961462 @default.
- W2017431319 hasConcept C105702510 @default.
- W2017431319 hasConcept C134018914 @default.
- W2017431319 hasConcept C142724271 @default.
- W2017431319 hasConcept C16005928 @default.
- W2017431319 hasConcept C202751555 @default.
- W2017431319 hasConcept C203014093 @default.
- W2017431319 hasConcept C204232928 @default.
- W2017431319 hasConcept C2775934546 @default.
- W2017431319 hasConcept C2776458125 @default.
- W2017431319 hasConcept C2777074287 @default.
- W2017431319 hasConcept C2778024521 @default.
- W2017431319 hasConcept C2778260677 @default.
- W2017431319 hasConcept C2778292693 @default.
- W2017431319 hasConcept C2779134260 @default.
- W2017431319 hasConcept C2779306644 @default.
- W2017431319 hasConcept C2780439664 @default.
- W2017431319 hasConcept C2780664588 @default.
- W2017431319 hasConcept C55493867 @default.
- W2017431319 hasConcept C71924100 @default.
- W2017431319 hasConcept C86803240 @default.
- W2017431319 hasConceptScore W2017431319C105702510 @default.
- W2017431319 hasConceptScore W2017431319C134018914 @default.
- W2017431319 hasConceptScore W2017431319C142724271 @default.
- W2017431319 hasConceptScore W2017431319C16005928 @default.
- W2017431319 hasConceptScore W2017431319C202751555 @default.
- W2017431319 hasConceptScore W2017431319C203014093 @default.
- W2017431319 hasConceptScore W2017431319C204232928 @default.
- W2017431319 hasConceptScore W2017431319C2775934546 @default.
- W2017431319 hasConceptScore W2017431319C2776458125 @default.
- W2017431319 hasConceptScore W2017431319C2777074287 @default.
- W2017431319 hasConceptScore W2017431319C2778024521 @default.
- W2017431319 hasConceptScore W2017431319C2778260677 @default.
- W2017431319 hasConceptScore W2017431319C2778292693 @default.
- W2017431319 hasConceptScore W2017431319C2779134260 @default.
- W2017431319 hasConceptScore W2017431319C2779306644 @default.
- W2017431319 hasConceptScore W2017431319C2780439664 @default.
- W2017431319 hasConceptScore W2017431319C2780664588 @default.
- W2017431319 hasConceptScore W2017431319C55493867 @default.
- W2017431319 hasConceptScore W2017431319C71924100 @default.
- W2017431319 hasConceptScore W2017431319C86803240 @default.
- W2017431319 hasLocation W20174313191 @default.
- W2017431319 hasLocation W20174313192 @default.
- W2017431319 hasOpenAccess W2017431319 @default.
- W2017431319 hasPrimaryLocation W20174313191 @default.
- W2017431319 hasRelatedWork W1506187427 @default.
- W2017431319 hasRelatedWork W1979259860 @default.
- W2017431319 hasRelatedWork W1994584625 @default.
- W2017431319 hasRelatedWork W2000386027 @default.
- W2017431319 hasRelatedWork W2006223140 @default.
- W2017431319 hasRelatedWork W2011787625 @default.
- W2017431319 hasRelatedWork W2014048895 @default.
- W2017431319 hasRelatedWork W2018558067 @default.
- W2017431319 hasRelatedWork W2022250655 @default.
- W2017431319 hasRelatedWork W2045391651 @default.
- W2017431319 hasRelatedWork W2049902892 @default.
- W2017431319 hasRelatedWork W2050431327 @default.
- W2017431319 hasRelatedWork W2074577456 @default.
- W2017431319 hasRelatedWork W2083670599 @default.
- W2017431319 hasRelatedWork W2121050460 @default.
- W2017431319 hasRelatedWork W2136481244 @default.
- W2017431319 hasRelatedWork W2152226036 @default.
- W2017431319 hasRelatedWork W2321102680 @default.
- W2017431319 hasRelatedWork W2042284384 @default.
- W2017431319 hasRelatedWork W2048486696 @default.
- W2017431319 isParatext "false" @default.
- W2017431319 isRetracted "false" @default.
- W2017431319 magId "2017431319" @default.
- W2017431319 workType "article" @default.