FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017440981> ?p ?o ?g. }

• W2017440981 abstract "Cytolytic T lymphocytes (CTL) play an important role in the control of HIV infection. The eventual failure to contain HIV-1 infection may arise because of a functional impairment of HIV-specific CTL. We evaluated Gag-specific cytotoxicity in HIV-1-positive Ugandans. Expression of CD107, a marker for cytolytic activity, was present in CD45RA(bright) and CD45RA(dim) CD8(+) T cell populations in HIV-infected individuals. The frequency of Gag-specific CD107(+)CD45RA(bright)CD28(-)CCR7(-) CD8(+) T cells decreased with CD4 cell depletion and correlated with the presence of Gag-specific T helper response. In contrast, the frequency of Gag-specific CD107(+)CD45RA(dim)CD28(-)CCR7(-) CD8(+) T cells within the same individuals has no significant association with viral load or CD4 cell count. The ratio of CD45RA(bright) to CD45RA(dim) CTL correlates significantly with CD4 cell count. This positive association decreases with antiretroviral treatment (ARV), indicating that suppression of viral replication alters the balance of circulating Gag-specific CD8(+) effector T cells. Subsets of cytolytic T cells may have distinct antiviral functions and further characterization of these effector CD8(+) T cells may yield important information on T cell regulation and dysfunction in HIV infection." @default.
• W2017440981 created "2016-06-24" @default.
• W2017440981 creator A5006641773 @default.
• W2017440981 creator A5019234170 @default.
• W2017440981 creator A5031998768 @default.
• W2017440981 creator A5036075930 @default.
• W2017440981 creator A5053442063 @default.
• W2017440981 creator A5064233969 @default.
• W2017440981 creator A5073416496 @default.
• W2017440981 creator A5086762658 @default.
• W2017440981 creator A5086948042 @default.
• W2017440981 date "2006-10-01" @default.
• W2017440981 modified "2023-09-24" @default.
• W2017440981 title "Presence of Distinct Subsets of Cytolytic CD8+T Cells in Chronic HIV Infection" @default.
• W2017440981 cites W1511763279 @default.
• W2017440981 cites W1515986708 @default.
• W2017440981 cites W1529197890 @default.
• W2017440981 cites W1568830440 @default.
• W2017440981 cites W1655510925 @default.
• W2017440981 cites W1815763197 @default.
• W2017440981 cites W1945834141 @default.
• W2017440981 cites W1964488853 @default.
• W2017440981 cites W1967684158 @default.
• W2017440981 cites W1970572484 @default.
• W2017440981 cites W1981136135 @default.
• W2017440981 cites W1981480494 @default.
• W2017440981 cites W1991255132 @default.
• W2017440981 cites W1994340919 @default.
• W2017440981 cites W1997346247 @default.
• W2017440981 cites W2009742856 @default.
• W2017440981 cites W2011646391 @default.
• W2017440981 cites W2031331647 @default.
• W2017440981 cites W2037343680 @default.
• W2017440981 cites W2042896101 @default.
• W2017440981 cites W2046313164 @default.
• W2017440981 cites W2050227969 @default.
• W2017440981 cites W2050349991 @default.
• W2017440981 cites W2057440703 @default.
• W2017440981 cites W2076534074 @default.
• W2017440981 cites W2093475848 @default.
• W2017440981 cites W2103182811 @default.
• W2017440981 cites W2107526519 @default.
• W2017440981 cites W2108381430 @default.
• W2017440981 cites W2115425082 @default.
• W2017440981 cites W2118971416 @default.
• W2017440981 cites W2119232577 @default.
• W2017440981 cites W2124192105 @default.
• W2017440981 cites W2126302947 @default.
• W2017440981 cites W2129114331 @default.
• W2017440981 cites W2130558808 @default.
• W2017440981 cites W2131174506 @default.
• W2017440981 cites W2135965641 @default.
• W2017440981 cites W2142038176 @default.
• W2017440981 cites W2142838880 @default.
• W2017440981 cites W2151303894 @default.
• W2017440981 cites W2151651155 @default.
• W2017440981 cites W2152416144 @default.
• W2017440981 cites W2155025120 @default.
• W2017440981 cites W2155844694 @default.
• W2017440981 cites W2156110652 @default.
• W2017440981 cites W2162170852 @default.
• W2017440981 cites W2166883229 @default.
• W2017440981 cites W2171282348 @default.
• W2017440981 cites W2339173512 @default.
• W2017440981 doi "https://doi.org/10.1089/aid.2006.22.1007" @default.
• W2017440981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17067271" @default.
• W2017440981 hasPublicationYear "2006" @default.
• W2017440981 type Work @default.
• W2017440981 sameAs 2017440981 @default.
• W2017440981 citedByCount "11" @default.
• W2017440981 countsByYear W20174409812012 @default.
• W2017440981 countsByYear W20174409812013 @default.
• W2017440981 countsByYear W20174409812019 @default.
• W2017440981 crossrefType "journal-article" @default.
• W2017440981 hasAuthorship W2017440981A5006641773 @default.
• W2017440981 hasAuthorship W2017440981A5019234170 @default.
• W2017440981 hasAuthorship W2017440981A5031998768 @default.
• W2017440981 hasAuthorship W2017440981A5036075930 @default.
• W2017440981 hasAuthorship W2017440981A5053442063 @default.
• W2017440981 hasAuthorship W2017440981A5064233969 @default.
• W2017440981 hasAuthorship W2017440981A5073416496 @default.
• W2017440981 hasAuthorship W2017440981A5086762658 @default.
• W2017440981 hasAuthorship W2017440981A5086948042 @default.
• W2017440981 hasConcept C142462285 @default.
• W2017440981 hasConcept C147969180 @default.
• W2017440981 hasConcept C154317977 @default.
• W2017440981 hasConcept C159047783 @default.
• W2017440981 hasConcept C167672396 @default.
• W2017440981 hasConcept C202751555 @default.
• W2017440981 hasConcept C203014093 @default.
• W2017440981 hasConcept C2522874641 @default.
• W2017440981 hasConcept C2776090121 @default.
• W2017440981 hasConcept C55493867 @default.
• W2017440981 hasConcept C6881719 @default.
• W2017440981 hasConcept C73588182 @default.
• W2017440981 hasConcept C86803240 @default.
• W2017440981 hasConcept C8891405 @default.
• W2017440981 hasConceptScore W2017440981C142462285 @default.
• W2017440981 hasConceptScore W2017440981C147969180 @default.
• W2017440981 hasConceptScore W2017440981C154317977 @default.

• next